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Chirogenesis in Chemical Science is an exciting new book that takes
readers inside the world of chirality and chirogenesis, guided by
Victor Borovkov and Riina Aav, both internationally renowned
experts on chirality. Chirality is a fundamental property of the
universe and has significance in different organic/inorganic
materials, living organisms, and human beings. The basic principle
of chirality is existence of an object in two mirror image forms,
which are not superimposable. This phenomenon is widely seen in
various fields of knowledge including mathematics, astronomy,
physics, chemistry, biology and ranging in scale from galaxies to
nuclear particles.In chemical science, chirality is generally
associated with a single molecule or group of molecules, which
symmetry properties belonging to the Cn or Dn point groups with the
simplest example of sp3 carbon atom bonded to four different
substituents. The dynamic processes of chirality generation,
modulation, transfer, amplification, etc. are termed
chirogenesis.This book provides readers with an integrated
knowledge on serine protease prostasin, starting with its
discovery, protein isolation, cDNA, and gene cloning, to its
functions in physiology and pathophysiology, and to its application
in the development of therapeutics. This is the first-of-its-kind
book that covers the history, present state of knowledge, and
future perspectives of the prototypic
glycosylphosphatidylinositol-anchored epithelial extracellular
serine protease prostasin, which is a key player in the regulation
and maintenance of the extracellular fluid homeostasis. The
chapters encapsulate all that has been learned about prostasin in
the technical sophistication, but more importantly, also highlight
a critical analysis on the problems with the current state of
research and outline the challenges for the future.
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