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Recently HPLC-MS/MS has gained increasing popularity in clinical
laboratories due to the advantages of the technology over other
methods, while the capital cost for instruments has been decreased.
HPLC-MS/MS provides high specificity and sensitivity for the
simultaneous measurement of several drugs and/or their major
metabolites in one single analytical run. In this book
chromatographic methods published in the last decade are reviewed
regarding their applicability to drug monitoring. HPLC methods for
anti-cancer drugs, bronchodilators, cardiovascular drugs,
antipsychotics, antibiotics, antiepileptic drugs, antidepressants,
and immunosuppressants have been presented comprehensively
regarding sample preparation and chromatographic separation.
Supportive information has been included on HPLC analysis and
sample preparation.
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