|
Showing 1 - 6 of
6 matches in All Departments
Beginning Apache Cassandra Development introduces you to one of the
most robust and best-performing NoSQL database platforms on the
planet. Apache Cassandra is a document database following the JSON
document model. It is specifically designed to manage large amounts
of data across many commodity servers without there being any
single point of failure. This design approach makes Apache
Cassandra a robust and easy-to-implement platform when high
availability is needed. Apache Cassandra can be used by developers
in Java, PHP, Python, and JavaScript-the primary and most commonly
used languages. In Beginning Apache Cassandra Development, author
and Cassandra expert Vivek Mishra takes you through using Apache
Cassandra from each of these primary languages. Mishra also covers
the Cassandra Query Language (CQL), the Apache Cassandra analog to
SQL. You'll learn to develop applications sourcing data from
Cassandra, query that data, and deliver it at speed to your
application's users. Cassandra is one of the leading NoSQL
databases, meaning you get unparalleled throughput and performance
without the sort of processing overhead that comes with traditional
proprietary databases. Beginning Apache Cassandra Development will
therefore help you create applications that generate search results
quickly, stand up to high levels of demand, scale as your user base
grows, ensure operational simplicity, and-not least-provide
delightful user experiences.
The objective of this study was to understand the pitfalls of the
poor oocyte cleavage and subsequent embryo production by assessing
the developmental competence of the oocytes in buffalo using
parthenogenesis as a model which was compared with IVF (natural
activation). Buffalo ovaries were collected from slaughter house
and matured oocytes were subjected to either IVF (control) or
chemical activation (treatment) 7% ethanol (ET)for 7 min ] 2.5 mM
6-Di methyl amino purine (6-DMAP) for 4 hr, or 7% ET for 7 min + 10
ug/ml Cycloheximide (CHX) for 6 hr or 7% ET for 7 min + 2.5 mM
6-DMAP + 10 ug/ml CHX for 6 hr]. Fertilized and chemically
activated oocytes were cultured in mSOF medium for 8 days to study
embryo development.In conclusion, the results of parthenogenesis,
revealed that buffalo oocytes had better inherent developmental
competence and the poor cleavage and embryo development following
IVF, in our study, may partly be due to the poor quality of
frozen-thawed sperm, improper sperm capacitation and/ or
fertilization. Further, high ambient temperature adversely affected
the cleavage and embryo development following IVF.
Since AO and BY has been shown to be indiscriminately added in food
and oil and both have genotoxic and carcinogenic/mutagenic
potential. Hence, following studies are proposed as a part of this
dissertation to fill up the above mentioned lacuna in argemone oil
and butter yellow intoxication. Reproductive toxicity: Consumption
of edible oil adulterated with argemone oil (AO) is also presumed
to be one of the factors for reduction in sperm count and we have
observed that alterations in germ cell apoptosis by a disruption in
contact mediated communication between the Sertoli cells and germ
cells, may subsequently lead to testicular impairment. Hepatic
Toxicity: The study suggests that AO and BY treatment may cause
oxidative stress and diminished phase I & II enzymes leading to
accumulation of parent compound (s) or their metabolites which may
results in the formation of liver cancer. Carcinogenic potential in
gall bladder in vitro and in vivo study suggests that AO and BY are
responsible for producing gall bladder carcinoma in mice along with
stone formation in AO exposure.
|
|