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First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void. This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void. This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
The application of immobilized enzymes in medicine is the main
objective of this book. The author reviews natural and synthetic
carriers for enzyme immobilization, chemistry of enzyme binding,
and in-vitro and in-vivo properties of immobilized enzymes. Four
chapters are dedicated to clinical use of immobilized enzymes.
Systems of Nanovesicular Drug Delivery provides a thorough insight
into the complete and up-to-date discussions about the preparation,
properties and drug delivery applications of various nanovesicles.
This volume discusses cubosomes, proniosomes and niosomes,
dendrimerosomes and other new and effective approaches for drug
delivery. It will be a valuable title and resource for academics
and pharmaceutical scientists, including industrial pharmacists,
analytical scientists, health care professionals and regulatory
scientists actively involved in pharmaceutical products and process
development of tailor-made polysaccharides in drug delivery
applications. Recently, there have been a number of outstanding
nanosystems in nanovesicular carrier-forms (such as nanoemulsions,
self-nanoemulsifying systems, nanoliposomes, nanotransferosomes,
etc.), that have been researched and developed for efficient drug
delivery by many formulators, researchers and scientists. However,
no previously published books have covered all these drug delivery
nanovesicles collectively in a single resource.
Applications of Nanovesicular Drug Delivery provides thorough
insights and a complete and updated discussion on the preparation,
properties and drug delivery applications of various nanovesicles.
This volume will discuss target-specific drug application, such as
ocular, transdermal, nasal, intravenous and oral delivery. This
title is a valuable resource for academics, pharmaceutical
scientists, including industrial pharmacists and analytical
scientists, health care professionals and regulatory scientists
actively involved in pharmaceutical products and process
development of tailored-made polysaccharides in drug delivery
applications. Recently, there have been a number of outstanding
nanosystems in nanovesicular carrier-forms (such as nanoemulsions,
self-nanoemulsifying systems, nanoliposomes, nanotransferosomes,
etc.), that have been researched and developed for efficient drug
delivery by many formulators, researchers and scientists. However,
no previously published books have covered all these drug delivery
nanovesicles collectively in a single resource.
Drugs usually have no natural affinity for the cells, tissues and
organs where therapeutic effects are needed, which frequently
results in low efficiency and unwanted side effects. This concern
is even more profound when using highly potent and cytotoxic
anticancer drugs or specific agents, such as enzymes and genetic
materials, since their effective and safe action requires precise
cellular or even sub-cellular addressing in the target organ. To
meet safety, efficiency and specificity requirements, drugs somehow
must be targeted to the sites of their expected therapeutic action.
The idea of the "magic bullet," or drug targeting, proposed by
Erlich a century ago, generates great and continuously growing
interest in biomedical, industrial and financial circles. This book
is focused on the strategies designed to target therapeutic or
diagnostic agents to the disease sites. In an attempt to include in
this volume the set of chapters reflecting both traditional and
emerging areas of drug targeting, we have contacted many leading
scientists in the field asking for their contributions. Their
responses were most favorable and encouraging. As a result, we have
succeeded in assembling a series of outstanding contributions
reflecting practically all the key areas of drug targeting. The
final structure of this book is as follows.
Drugs usually have no natural affinity for the cells, tissues and
organs where therapeutic effects are needed, which frequently
results in low efficiency and unwanted side effects. This concern
is even more profound when using highly potent and cytotoxic
anticancer drugs or specific agents, such as enzymes and genetic
materials, since their effective and safe action requires precise
cellular or even sub-cellular addressing in the target organ. To
meet safety, efficiency and specificity requirements, drugs somehow
must be targeted to the sites of their expected therapeutic action.
The idea of the "magic bullet," or drug targeting, proposed by
Erlich a century ago, generates great and continuously growing
interest in biomedical, industrial and financial circles. This book
is focused on the strategies designed to target therapeutic or
diagnostic agents to the disease sites. In an attempt to include in
this volume the set of chapters reflecting both traditional and
emerging areas of drug targeting, we have contacted many leading
scientists in the field asking for their contributions. Their
responses were most favorable and encouraging. As a result, we have
succeeded in assembling a series of outstanding contributions
reflecting practically all the key areas of drug targeting. The
final structure of this book is as follows.
Drug delivery systems and pharmaceutical nanocarriers that respond
to different types of stimuli, such as internal ones, intrinsic for
the pathological area (changes in pH, temperature, redox condition,
activity of certain enzymes), or external, artificially applied
(magnetic field, ultrasound, various irradiations), represent an
important and continuously growing area of research. Smart
Phramaceutical Nanocarriers overviews the various stimuli used for
drug release and delivery by smart pharmaceutical carriers and
presents cutting-edge research and the newest data from the leading
laboratories in each area.
Written by key experts in the field of nanomedicine, this book
provides a broad introduction to the important field of
nanomedicine and application of nanotechnology for drug delivery.
It covers up-to-date information regarding various nanoparticulate
drug delivery systems, describes the various opportunities for the
application of nanoparticular drug carriers in different areas of
clinical medicine, and analyzes already available information on
their clinical applications. This book can be used as an advanced
textbook by graduate students and young scientists and clinicians
at the early stages of their career. It is also suitable for
non-experts from related areas of chemistry, biochemistry,
molecular biology, biomedical engineering, physiology, experimental
and clinical medicine, and pharmaceutical sciences, who are
interested in general problems of drug delivery and drug targeting,
as well as in more specialized topics of using
nanoparticulate-mediated drug delivery approaches in the individual
areas of clinical medicine. Prof Torchilin is an expert in
Nanomedicine and a recipient of numerous awards including the Lenin
Prize in Science & Technology of the former USSR, membership in
the European Academy of Sciences, and AAPS Research Achievement
Award in Pharmaceutics and Drug Delivery. He served as an Associate
Professor of Radiology at Harvard Medical School before joining
Northeastern University as the Chairman of the Department of
Pharmaceutical Sciences.
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