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Biomedical Aspects of Drug Targeting (Hardcover, 2002 ed.)
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Biomedical Aspects of Drug Targeting (Hardcover, 2002 ed.)
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Drugs usually have no natural affinity for the cells, tissues and
organs where therapeutic effects are needed, which frequently
results in low efficiency and unwanted side effects. This concern
is even more profound when using highly potent and cytotoxic
anticancer drugs or specific agents, such as enzymes and genetic
materials, since their effective and safe action requires precise
cellular or even sub-cellular addressing in the target organ. To
meet safety, efficiency and specificity requirements, drugs somehow
must be targeted to the sites of their expected therapeutic action.
The idea of the "magic bullet," or drug targeting, proposed by
Erlich a century ago, generates great and continuously growing
interest in biomedical, industrial and financial circles. This book
is focused on the strategies designed to target therapeutic or
diagnostic agents to the disease sites. In an attempt to include in
this volume the set of chapters reflecting both traditional and
emerging areas of drug targeting, we have contacted many leading
scientists in the field asking for their contributions. Their
responses were most favorable and encouraging. As a result, we have
succeeded in assembling a series of outstanding contributions
reflecting practically all the key areas of drug targeting. The
final structure of this book is as follows.
General
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