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This collection explores up-to-date descriptions of known G
protein-coupled receptor kinase (GRK)-dependent mechanisms, both
associated with G protein-coupled receptor (GPCR) functions and the
receptor-independent. The chapters cover a wide range of studies
from invertebrates to humans, with sections of the volume covering
GRK structure, mechanisms of activation, and interaction with
GPCRs, GRKs in cell signaling, as well as physiological and
pathophysiological mechanisms regulated by GRKs. Written for the
Methods in Pharmacology and Toxicology series, this book features
the kind of practical detail necessary for success in the
laboratory. Authoritative and timely, G Protein-Coupled Receptor
Kinases features the kind of comprehensive mechanistic elucidation
of GRK functions and their regulation in cells necessary for a
better understanding of cell biology as well as for devising novel
research approaches and therapeutic strategies.
This volume describes our current understanding of the biological
role of visual and non-visual arrestins in different cells and
tissues, focusing on the mechanisms of arrestin-mediated regulation
of GPCRs and non-receptor signaling proteins in health and disease.
The book covers wide range of arrestin functions, emphasizing
therapeutic potential of targeting arrestin interactions with
individual partners.
This collection explores up-to-date descriptions of known G
protein-coupled receptor kinase (GRK)-dependent mechanisms, both
associated with G protein-coupled receptor (GPCR) functions and the
receptor-independent. The chapters cover a wide range of studies
from invertebrates to humans, with sections of the volume covering
GRK structure, mechanisms of activation, and interaction with
GPCRs, GRKs in cell signaling, as well as physiological and
pathophysiological mechanisms regulated by GRKs. Written for the
Methods in Pharmacology and Toxicology series, this book features
the kind of practical detail necessary for success in the
laboratory. Authoritative and timely, G Protein-Coupled Receptor
Kinases features the kind of comprehensive mechanistic elucidation
of GRK functions and their regulation in cells necessary for a
better understanding of cell biology as well as for devising novel
research approaches and therapeutic strategies.
This volume describes our current understanding of the
biological role of visual and non-visual arrestins in different
cells and tissues, focusing on the mechanisms of arrestin-mediated
regulation of GPCRs and non-receptor signaling proteins in health
and disease. The book covers wide range of arrestin functions,
emphasizing therapeutic potential of targeting arrestin
interactions with individual partners.
Arrestins: Structure and Function in Vision and Beyond examines the
structural basis of the function of arrestin proteins in the brain.
Linking basic, translational and clinical research, this volume
begins with history and basic signaling principles and then expands
to the use of proteins as potential therapeutic targets. Multiple
cellular activities are detailed, including activation, signaling,
GPCR endocytosis, and ERK signaling, with chapters examining both
visual and non-visual arrestins. Experts in their respective fields
are featured throughout, making this book essential reading for
anyone who wants to explore the basic science underlying these
signaling proteins.
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