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Many thought that the 'German question', that had shaped European
history so catastrophically in the last century, had been solved
for good in 1990. And the last elections seemed to confirm that
Germany was on the road to 'normalcy'. However, at the beginning of
the new century, many see Germany as a problem case in Europe. This
raises the question about the future of Germany and the performance
of the incumbent government. The book addresses these issues by
examining the policies and politics of the Red-Green government and
by putting recent changes and developments in this country in a
long-term perspective.
This volume reviews a series of different publications dealing with
orotic acid. Orotic acid was isolated from cow's milk 75 years ago
by Biscaro and Belloni in Italy. Fifty years later again Italian
scientists described the growth-promoting activity of orotic acid
in vitamin B -deficient animals. 12 Orotic acid is the precursor of
pyrimidine nucleotides which are involved in many biochemical
reactions: UTP and CTP, as substrates for RNA polymerase, and UDP
sugars, as substrates for carbohydrate containing macromolecules,
e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of
these pyrimidines is well regulated. Disturbance of the
biosynthetic pathway or trapping of individual pyrimidine
nucleotides may lead to severe metabolic and structural alterations
of cells. Synthesis, biochemical aspects and physiological role are
reviewed in nine chapters. In the last two decades increasing
interest in orotic acid came from several studies showing
protective or therapeutic or beneficial effects of this compound in
different kinds of organ injuries: various forms of hepatic
insufficiency, myocardial infarction, encephalopathy, memorization
pro cesses, mentioned in Chapters 8 and 9. At the end of this
overview a Bibliography in an alphabetical order with 673
references may give further insight in this topic."
Many thought that the "German question," which had shaped European
history so catastrophically in the last century, had been solved
for good in 1990. Furthermore, the elections in 1998 seemed to
confirm that Germany was on the road to "normalcy." For the first
time in postwar German history a ruling party coalition was totally
unseated by elections. Germany thus finally joined other western
democracies as a state where a change of government following
elections is commonplace. However, starting in the new millennium
many have begun to see Germany as a problem case in Europe yet
again. This raises questions about the future of Germany and the
performance of the Red-Green government that this book seeks to
answer. The contributors to this volume examine policies and
politics of the Red-Green government in Germany, put recent changes
and developments in this country in a long-term perspective, and
provide conclusions about future developments.
Cell-cell and cell-matrix interactions are of fundamental
importance for the development and the maintenance of tissues and
organs in multicellular organisms. Adhesive processes are mediated
and controlled by an increasingly large and complex number of cell
adhesion molecules that are anchored to the cell surface membrane
by transmembrane domains. According to their structural and
functional features, cell adhesion molecules have been classified
into at least four major families: the integrins, selectins,
cadherins and members of the immunoglobulin superfamily. Apart from
linking cells to each other or to components of the extracellular
matrix, cell adhesion molecules function also as receptors that
interact via their cytoplasmic domain with numerous signalling
molecules including protein kinases and phosphatases, G-proteins,
or proteins of the beta-catenin/armadillo family. Cell adhesion
molecules can activate various signalling pathways and as a
consequence play a crucial role in the regulation of cell
differentiation, proliferation, migration and apoptosis. During the
last decade it has been recognized that acquired as well as
inherited defects of cell adhesion molecules and adhesion-linked
signalling molecules are the molecular basis of various types of
disease including cancer, infectious and inflammatory disease,
connective tissue disorders or blistering disease.
This book is the proceedings of a Falk Workshop held in Berlin,
Germany, on January 23-24, 2003, which brought together experts in
different fields of research to stimulate the transfer of findings
from basic research to clinical application. Section I focuses on
cell adhesion molecules of the liver and their role
inhepatocarcinogenesis and inflammatory liver disease. Section II
deals with infection and fibrosis and with transforming growth
factor beta (TGF-beta). Morphogenesis, cell migration and
inflammation are the subject of Section III with a focus on the
role of integrins in blood cell-endothelial interactions. In
Section IV the importance of cell adhesion molecules for cancer and
their role as potential target for cancer therapy will be
discussed.
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