Orotic Acid - Synthesis, Biochemical Aspects and Physiological Role (Paperback, Softcover reprint of the original 1st ed. 1980)

This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic."

General

Imprint:	Springer
Country of origin:	Netherlands
Release date:	October 2011
First published:	1980
Authors:	A. Cihak • W. Reutter
Dimensions:	235 x 155 x 7mm (L x W x T)
Format:	Paperback
Pages:	118
Edition:	Softcover reprint of the original 1st ed. 1980
ISBN-13:	978-9400980457
Categories:	Books > Medicine > Clinical & internal medicine > Hepatology
LSN:	9400980450
Barcode:	9789400980457

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