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Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
Through a unique dataset covering half a century of policy-making in Britain, this book traces how topics like the economy, international affairs, and crime have changed in their importance to government. The data concerns key venues of decision-making - the Queen's Speech, laws and budgets - which are compared to the media and public opinion. These trends are conveyed through accessible figures backed up by a series of examples of important policies. As a result, the book throws new light on the key points of change in British politics, such as Thatcherism and New Labour and explores different approaches to agenda setting helping to account for these changes: incrementalism, the issue attention cycle and the punctuated equilibrium model. What results is the development of a new approach to agenda setting labelled focused adaptation whereby policy-makers respond to structural shifts in the underlying pattern of attention.
This book offers a close reading of Romans that treats Paul as a
radical political thinker by showing the relationship between
Paul's perspective and that of secular political theorists. Turning
to both ancient political philosophers (Plato, Aristotle, and
Cicero) and contemporary post-Marxists (Agamben, Badiou, Derrida,
and centsiYek), Jennings presents Romans as a sustained argument
for a new sort of political thinking concerned with the possibility
and constitution of just socialities.
Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
This book offers a close reading of Romans that treats Paul as a
radical political thinker by showing the relationship between
Paul's perspective and that of secular political theorists. Turning
to both ancient political philosophers (Plato, Aristotle, and
Cicero) and contemporary post-Marxists (Agamben, Badiou, Derrida,
and Zižek), Jennings presents Romans as a sustained argument for a
new sort of political thinking concerned with the possibility and
constitution of just socialities.
"This remarkably fine book is timely and provocative. It is also
one of a kind: a book that advances detailed exegesis of the New
Testament, above all Paul's Letter to the Romans, by drawing deeply
on Derrida's reflections concerned with justice and law, gift or
grace, debt, duty, love, hospitality, and forgiveness."--Peggy
Kamuf, University of Southern California
Benjamin's famous "Work of Art" essay sets out his boldest thoughts--on media and on culture in general--in their most realized form, while retaining an edge that gets under the skin of everyone who reads it. In this essay the visual arts of the machine age morph into literature and theory and then back again to images, gestures, and thought. This essay, however, is only the beginning of a vast collection of writings that the editors have assembled to demonstrate what was revolutionary about Benjamin's explorations on media. Long before Marshall McLuhan, Benjamin saw that the way a bullet rips into its victim is exactly the way a movie or pop song lodges in the soul. This book contains the second, and most daring, of the four versions of the "Work of Art" essay--the one that addresses the utopian developments of the modern media. The collection tracks Benjamin's observations on the media as they are revealed in essays on the production and reception of art; on film, radio, and photography; and on the modern transformations of literature and painting. The volume contains some of Benjamin's best-known work alongside fascinating, little-known essays--some appearing for the first time in English. In the context of his passionate engagement with questions of aesthetics, the scope of Benjamin's media theory can be fully appreciated.
The Bauhaus, the school of art and design founded in Germany in 1919 and shut down by the Nazis in 1933, brought together artists, architects and designers--among them Anni and Josef Albers, Herbert Bayer, Marcel Breuer, Lyonel Feininger, Walter Gropius, Johannes Itten, Vasily Kandinsky, Paul Klee, Laszlo Moholy-Nagy, Lilly Reich, Oskar Schlemmer, Gunta Stolzl--in an extraordinary conversation on the nature of art in the industrial age. Aiming to rethink the form of modern life, the Bauhaus became the site of a dazzling array of experiments in the visual arts that have profoundly shaped the world today. "Bauhaus 1919-1933: Workshops for Modernity," published to accompany a major multimedia exhibition, is The Museum of Modern Art's first comprehensive treatment of the subject since its famous Bauhaus exhibition of 1938, and offers a new generational perspective on the twentieth century's most influential experiment in artistic education. Organized in collaboration with the three major Bauhaus collections in Germany (the Bauhaus-Archiv Berlin, the Stiftung Bauhaus Dessau and the Klassic Stiftung Weimar), "Bauhaus 1919-1933" examines the extraordinarily broad spectrum of the school's products, including industrial design, furniture, architecture, graphics, photography, textiles, ceramics, theater and costume design, painting and sculpture. Many of the objects discussed and illustrated here have rarely if ever been seen or published outside Germany. Featuring approximately 400 color plates, richly complemented by documentary images, "Bauhaus 1919-1933" includes two overarching essays by the exhibition's curators, Barry Bergdoll and Leah Dickerman, that present new perspectives on the Bauhaus. Shorter essays by more than 20 leading scholars apply contemporary viewpoints to 30 key Bauhaus objects, and an illustrated narrative chronology provides a dynamic glimpse of the Bauhaus' lived history.
In the frenzied final years of the Weimar Republic, amid economic collapse and mounting political catastrophe, Walter Benjamin emerged as the most original practicing literary critic and public intellectual in the German-speaking world. Volume 2 of the "Selected Writings" is now available in paperback in two parts. In Part 1, Benjamin is represented by two of his greatest literary essays, "Surrealism" and "On the Image of Proust," as well as by a long article on Goethe and a generous selection of his wide-ranging commentary for Weimar Germany's newspapers. Part 2 contains, in addition to the important longer essays, "Franz Kafka," "Karl Kraus," and "The Author as Producer," the extended autobiographical meditation "A Berlin Chronicle," and extended discussions of the history of photography and the social situation of the French writer, previously untranslated shorter pieces on such subjects as language and memory, theological criticism and literary history, astrology and the newspaper, and on such influential figures as Paul Valery, Stefan George, Hitler, and Mickey Mouse.
Radical critic of a European civilization plunging into darkness, yet commemorator of the humane traditions of the old bourgeoisie--such was Walter Benjamin in the later 1930s. This volume, the third in a four-volume set, offers twenty-seven brilliant pieces, nineteen of which have never before been translated. The centerpiece, "A Berlin Childhood around 1900," marks the first appearance in English of one of the greatest German works of the twentieth century: a profound and beautiful account of the vanished world of Benjamin's privileged boyhood, recollected in exile. No less remarkable are the previously untranslated second version of Benjamin's most famous essay, "The Work of Art in the Age of Its Technological Reproducibility," with its striking insights into the relations between technology and aesthetics, and "German Men and Women," a book in which Benjamin collects twenty-six letters by distinguished Germans from 1783 to 1883 in an effort to preserve what he called the true humanity of German tradition from the debasement of fascism. Volume 3 also offers extensively annotated translations of essays that are key to Benjamin's rewriting of the story of modernism and modernity--such as "The Storyteller" and "Paris, the Capital of the Nineteenth Century"--as well as a fascinating diary from 1938 and penetrating studies of Bertolt Brecht, Franz Kafka, and Eduard Fuchs. A narrative chronology details Benjamin's life during these four harrowing years of his exile in France and Denmark. This is an essential collection for anyone interested in his work.
"This remarkably fine book is timely and provocative. It is also
one of a kind: a book that advances detailed exegesis of the New
Testament, above all Paul's Letter to the Romans, by drawing deeply
on Derrida's reflections concerned with justice and law, gift or
grace, debt, duty, love, hospitality, and forgiveness."--Peggy
Kamuf, University of Southern California
"Every line we succeed in publishing today...is a victory wrested from the powers of darkness." So wrote Walter Benjamin in January 1940. Not long afterward, he himself would fall prey to those powers, a victim of suicide following a failed attempt to flee the Nazis. However insistently the idea of catastrophe hangs over Benjamin's writings in the final years of his life, the "victories wrested" in this period nonetheless constitute some of the most remarkable twentieth-century analyses of the emergence of modern society. The essays on Charles Baudelaire are the distillation of a lifetime of thinking about the nature of modernity. They record the crisis of meaning experienced by a civilization sliding into the abyss, even as they testify to Benjamin's own faith in the written word. This volume ranges from studies of Baudelaire, Brecht, and the historian Carl Jochmann to appraisals of photography, film, and poetry. At their core is the question of how art can survive and thrive in a tumultuous time. Here we see Benjamin laying out an ethic for the critic and artist--a subdued but resilient heroism. At the same time, he was setting forth a sociohistorical account of how art adapts in an age of violence and repression. Working at the height of his powers to the very end, Benjamin refined his theory of the mass media that culminated in the final version of his essay "The Work of Art in the Age of Its Technological Reproducibility." Also included in this volume is his influential piece "On the Concept of History," completed just before his death. The book is remarkable for its inquiry into the nature of "the modern" (especially as revealed in Baudelaire), for its ideas about thetransmogrification of art and the radical discontinuities of history, and for its examples of humane life and thought in the midst of barbarism. The entire collection is eloquent testimony to the indomitable spirit of humanity under siege.
Walter Benjamin is one of the twentieth century's most important intellectuals, and also one of its most elusive. His writings-mosaics incorporating philosophy, literary criticism, Marxist analysis, and a syncretistic theology-defy simple categorization. And his mobile, often improvised existence has proven irresistible to mythologizers. His writing career moved from the brilliant esotericism of his early writings through his emergence as a central voice in Weimar culture and on to the exile years, with its pioneering studies of modern media and the rise of urban commodity capitalism in Paris. That career was played out amid some of the most catastrophic decades of modern European history: the horror of the First World War, the turbulence of the Weimar Republic, and the lengthening shadow of fascism. Now, a major new biography from two of the world's foremost Benjamin scholars reaches beyond the mosaic and the mythical to present this intriguing figure in full. Howard Eiland and Michael Jennings make available for the first time a rich store of information which augments and corrects the record of an extraordinary life. They offer a comprehensive portrait of Benjamin and his times as well as extensive commentaries on his major works, including "The Work of Art in the Age of Its Technological Reproducibility," the essays on Baudelaire, and the great study of the German Trauerspiel. Sure to become the standard reference biography of this seminal thinker, Walter Benjamin: A Critical Life will prove a source of inexhaustible interest for Benjamin scholars and novices alike.
Walter Benjamin was one of the most original and important critical voices of the twentieth century, but until now only a few of his writings have been available in English. Harvard University Press has now undertaken to publish a significant portion of his work in definitive translation, under the general editorship of Michael W. Jennings. This volume, the first of three, will at last give readers of English a true sense of the man and the mans' theets of his thought. A separate volume will consist of his book "The Arcades Project," the magnum opus of his Paris years. The writer Walter Benjamin emerged our of the head-on collision of an idealistic youth movement and the First World War, which Benjamin and his close friends thought immoral. He walked away from the wreck scarred yet determined "to be considered as the principal critic of German literature." But the scene as he found it was dominated by "talented fakes," so-to use his words-"only a terrorist campaign would I suffice" to effect radical change. This book offers the record of the first phase of that campaign, culminating with "One-Way Street," one of the most significant products of the German avant-garde of the Twenties. Against conformism, homogeneity, and gentrification of all life into a new world order, Benjamin made the word his sword. Volume I of the "Selected Writings" brings together essays long and short, academic treatises, reviews, fragments, and privately circulated pronouncements. Fully five-sixths of this material has never before been translated into English. The contents begin in 1913, when Benjamin, as an undergraduate in imperial Germany, was president of a radical youth group, and take usthrough 1926, when he had already begun, with his explorations of the world of mass culture, to emerge as a critical voice in Weimar Germany's most influential journals. The volume includes a number of his most important works, including "Two Poems by Friedrich Holderlin," "Goethe's Elective Affinities," "The Concept of Criticism in German Romanticism," "The Task of the Translator," and "One-Way Street." He is as compelling and insightful when musing on riddles or children's books as he is when dealing with weightier issues such as the philosophy of language, symbolic logic, or epistemology. We meet Benjamin the youthful idealist, the sober moralist, the political theorist, the experimentalist, the translator, and, above all, the virtual king of criticism, with his magisterial exposition of the basic problems of aesthetics. Benjamin's sentences provoke us to return to them again and again, luring us as though with the promise of some final revelation that is always being postponed. He is by turns fierce and tender, melancholy and ebullient; he is at once classically rooted, even archaic, in his explorations of the human psyche and the world of things, and strikingly progressive in his attitude toward society and what he likes to call the organs of the collective (its architectures, fashions, signboards). Throughout, he displays a far-sighted urgency, judging the present on the basis of possible futures. And he is gifted with a keen sense of humor. Mysterious though he may sometimes be (his Latvian love, Asia Lacis, once described him as a visitor from another planet), Benjamin remains perhaps the most consistently surprising and challenging of critical writers.
Many books on the Christian doctrine of atonement have been published in recent years. Some point out the difficulties of traditional atonement theories; others attempt a revision of one of the classical three types; others attempt to combine aspects of these types.Jennings attempts something new: by approaching the question of the meaning of the cross through close attention to the biblical passages that serve as the basis of any reflection on the cross of Jesus and an engagement with patristic as well as contemporary discussion. The result is an alternative theology of the cross that grounds the message concerning the cross in the socio-political reality in which it was historically located and points to the way in which this message bears upon contemporary social and ecclesial reality.Jennings's truly fresh understanding for Christians of the meaning of Jesus' death specifically grounds the cross in the concrete political confrontation within which it occurred, relates the message about the cross to the practice of Jesus (thus keeping in relationship the gospels and the theology of Paul), and shows how the cross bears on overcoming of human division and sin, reconciliation to God, and new forms of social reality in the community of the crucified.
When a wounded wild rabbit is found in the front yard, he is given a good home and a memorable name by a twelve-year-old with a liking for basketball, the trombone, and the newspaper's daily horoscope. But Orwell is no ordinary rabbit. It soon seems that he is attempting to reward his young caretaker by mysteriously sending coded messages in the form of predictions: the final score of the Super Bowl, advance notice of a pop quiz at school, tomorrow's winning lottery number! Can this little rabbit foretell the future? Can Orwell actually make luck happen? Here is a magical and heartwarming story about kindness, friendship, and hope in the shadow of fortune's ever-turning wheel.
The very suggestion that there may be homoeroticism in Hebrew narrative may seem odd given the supposition that the religion and culture of ancient Israel resolutely opposed same sex erotic relationships. The apparent prohibition of homosexuality in Leviticus and the story of Sodom from Genesis have been made to speak for the whole Hebrew Bible. The oddity of this situation has not been lost on some interpreters who have recognized that the story of Sodom tells us no more about attitudes toward what we call homosexuality than the story of the rape of Dina tells us about attitudes toward heterosexuality. Prof. Jennings says that the well-known eroticism of the Hebrew Bible is not confined to heterosexuality but also includes an astonishing diversity of material that lends itself to homoerotic interpretation. In Part one, Jennings examines saga materials associated with David. It is no innovation to detect in the David and JonathanGCOs relationship at least the outline of a remarkable love story between two men. What becomes clear, however, is that the tale is far more complex than this since it involves Saul and is set within a context of a warrior society that takes for granted that male heroes will be accompanied by younger or lower status males.
This provocative volume illuminates a dimension of John Wesley's theology that has received insufficient attention: his deep and abiding commitment to the poor. By focusing on the radical nature of Wesley's "evangelical economics," Theodore W. Jennings, Jr., provides an important corrective to the view that Wesley was concerned with the salvation of souls only, and not also with the social conditions of human beings. |
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