Population genetics is the mathematical investigation of the changes in the genetic structure of populations brought about by selection, mutation, inbreeding, migration, and other phenomena, together with those random changes deriving from chance events. These changes are the basic components of evolutionary progress, and an understanding of their effect is therefore necessary for an informed discussion of the reasons for and nature of evolution. It would, however, be wrong to pretend that a mathematical theory, depending as it must on a large number of simplifying assump tions, should be accepted unreservedly and that its conclusions should be accepted uncritically. No-one would pretend that in the event of disagreement between observation and mathematical prediction, the discrepancy is due to anything other than the inadequacy of the mathematical treatment. The biological world is, of course, far too complex for the study of population genetics to be simply a branch of applied mathematics, so that while we are concerned here with the mathematical theory, I have tried to indicate which of our results should continue to apply in a context wider than that in which they are formally derived. The difficulties involved in the joint discussions of mathematical and genetical problems are obvious enough. I have tried to aim this book rather more at the mathematician than at the geneticist, and for this reason a brief glossary of common genetical terms is included."

This book brings together the personal accounts and reflections of nineteen mathematical model-builders, whose specialty is probabilistic modelling. The reader may well wonder why, apart from personal interest, one should commission and edit such a collection of articles. There are, of course, many reasons, but perhaps the three most relevant are: (i) a philosophicaJ interest in conceptual models; this is an interest shared by everyone who has ever puzzled over the relationship between thought and reality; (ii) a conviction, not unsupported by empirical evidence, that probabilistic modelling has an important contribution to make to scientific research; and finally (iii) a curiosity, historical in its nature, about the complex interplay between personal events and the development of a field of mathematical research, namely applied probability. Let me discuss each of these in turn. Philosophical Abstraction, the formation of concepts, and the construction of conceptual models present us with complex philosophical problems which date back to Democritus, Plato and Aristotle. We have all, at one time or another, wondered just how we think; are our thoughts, concepts and models of reality approxim&tions to the truth, or are they simply functional constructs helping us to master our environment? Nowhere are these problems more apparent than in mathematical model ling, where idealized concepts and constructions replace the imperfect realities for which they stand."