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Based on extended fieldwork conducted between 2007 and 2019, this
book aims to answer a simple question: What is the meaning of home
for people living in vernacular settlements in rural China? This
question is particularly potent since rural China has experienced
rapid and fundamental changes in the twenty-first century under the
influences of national policies such as "Building a New Socialist
Countryside" enacted in 2006 and "Rural Revitalization" announced
in 2018. Drawing upon ethnographic fieldwork, building surveys,
archival research, and over 600 photographs taken by residents
along with their life stories, this book uncovers the meanings of
home from rural residents' perspectives, who belong to a social
group that is underrepresented in scholarship and underserved in
modern China. In other words, this study empowers rural residents
by giving them voice. This book links the concepts of place, home,
and tradition into an overarching argument: The meaning of home
rests on the ideas of tradition, including identity, consanguinity,
collectivity, social relations, land ownership, and rural
lifestyle. The Introduction and Chapter 4 of this book is available
for free in PDF format as Open Access from the individual product
page at www.routledge.com. It has been made available under a
Creative Commons Attribution-Non Commercial-No Derivatives 4.0
license.
The growing interest in using combination drugs to treat various
complex diseases has spawned the development of many novel
statistical methodologies. The theoretical development, coupled
with advances in statistical computing, makes it possible to apply
these emerging statistical methods in in vitro and in vivo drug
combination assessments. However, despite these advances, no book
has served as a single source of information for statistical
methods in drug combination research, nor has there been any
guidance for experimental strategies. Statistical Methods in Drug
Combination Studies fills that gap, covering all aspects of drug
combination research, from designing in vitro drug combination
studies to analyzing clinical trial data. Featuring contributions
from researchers in industry, academia, and regulatory agencies,
this comprehensive reference: Describes statistical models used to
characterize dose-response patterns of monotherapies and evaluate
the combination drug synergy Offers guidance for estimating
interaction indices and constructing their associated confidence
intervals to assess drug interaction Introduces a practical and
innovative Bayesian approach to Phase I cancer trials, including
actual trial examples to illustrate use Examines strategies in the
fixed-dose combination therapy clinical development via case
studies stemming from regulatory reviews Evaluates computational
tools and software packages used to apply novel statistical methods
in combination drug development Statistical Methods in Drug
Combination Studies provides researchers with a solid understanding
of the available statistical methods and computational tools and
how to apply them in drug combination studies. The book is equally
useful for statisticians to become better equipped to deal with
drug combination study design and analysis in their practice.
Develop Effective Immunogenicity Risk Mitigation Strategies
Immunogenicity assessment is a prerequisite for the successful
development of biopharmaceuticals, including safety and efficacy
evaluation. Using advanced statistical methods in the study design
and analysis stages is therefore essential to immunogenicity risk
assessment and mitigation strategies. Statistical Methods for
Immunogenicity Assessment provides a single source of information
on statistical concepts, principles, methods, and strategies for
detection, quantification, assessment, and control of
immunogenicity. The book first gives an overview of the impact of
immunogenicity on biopharmaceutical development, regulatory
requirements, and statistical methods and strategies used for
immunogenicity detection, quantification, and risk assessment and
mitigation. It then covers anti-drug antibody (ADA) assay
development, optimization, validation, and transfer as well as the
analysis of cut point, a key assay performance parameter in ADA
assay development and validation. The authors illustrate how to
apply statistical modeling approaches to establish associations
between ADA and clinical outcomes, predict immunogenicity risk, and
develop risk mitigation strategies. They also present various
strategies for immunogenicity risk control. The book concludes with
an explanation of the computer codes and algorithms of the
statistical methods. A critical issue in the development of
biologics, immunogenicity can cause early termination or limited
use of the products if not managed well. This book shows how to use
robust statistical methods for detecting, quantifying, assessing,
and mitigating immunogenicity risk. It is an invaluable resource
for anyone involved in immunogenicity risk assessment and control
in both non-clinical and clinical biopharmaceutical development.
The growing interest in using combination drugs to treat various
complex diseases has spawned the development of many novel
statistical methodologies. The theoretical development, coupled
with advances in statistical computing, makes it possible to apply
these emerging statistical methods in in vitro and in vivo drug
combination assessments. However, despite these advances, no book
has served as a single source of information for statistical
methods in drug combination research, nor has there been any
guidance for experimental strategies. Statistical Methods in Drug
Combination Studies fills that gap, covering all aspects of drug
combination research, from designing in vitro drug combination
studies to analyzing clinical trial data. Featuring contributions
from researchers in industry, academia, and regulatory agencies,
this comprehensive reference: Describes statistical models used to
characterize dose-response patterns of monotherapies and evaluate
the combination drug synergy Offers guidance for estimating
interaction indices and constructing their associated confidence
intervals to assess drug interaction Introduces a practical and
innovative Bayesian approach to Phase I cancer trials, including
actual trial examples to illustrate use Examines strategies in the
fixed-dose combination therapy clinical development via case
studies stemming from regulatory reviews Evaluates computational
tools and software packages used to apply novel statistical methods
in combination drug development Statistical Methods in Drug
Combination Studies provides researchers with a solid understanding
of the available statistical methods and computational tools and
how to apply them in drug combination studies. The book is equally
useful for statisticians to become better equipped to deal with
drug combination study design and analysis in their practice.
This book offers a systematic investigation of the ecological and
environmental issues related to the land cover changes in Nepal by
researchers from both China and Nepal. It discusses the
eco-environmental issues faced by Nepal, particularly in the hills
and mountain regions. It also sheds light on the global concerns
regarding the eco-environment issues of mountains, and analyzes the
various causes and potential consequences of eco-environmental
degradation in Nepal. The book is of particular interest to
students, researchers, experts, and decision-makers wanting to gain
a general overview of land cover in Nepal and its dynamics,
environment and natural resources, as well as mountain hazards.
This book systematically introduces magnetic flux leakage testing
principles and their applications in practice. Signal detection,
collection, processing, the inversion of magnetic flux leakage
defect and 3D imaging are discussed in detail with extensive
project experiences, making the book an essential reference for
researchers, developers and engineers in nondestructive testing.
This book introduces high power semiconductor laser packaging
design. The challenges of the design and various packaging and
testing techniques are detailed by the authors. New technologies
and current applications are described in detail.
Challenges in Design and Implementation of Middlewares for
Real-Time Systems brings together in one place important
contributions and up-to-date research results in this fast moving
area. Challenges in Design and Implementation of Middlewares for
Real-Time Systems serves as an excellent reference, providing
insight into some of the most challenging research issues in the
field.
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Embedded Software and Systems - Second International Conference, ICESS 2005, Xi'an, China, December 16-18, 2005, Proceedings (Paperback, 2005 ed.)
Laurence T. Yang, Xingshe Zhou, Wei Zhao, Zhaohui Wu, Yian Zhu, …
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R3,387
Discovery Miles 33 870
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Ships in 10 - 15 working days
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Welcome to the proceedings of the 2005 International Conference on
Emb- ded Software and Systems (ICESS 2005) held in Xian, China,
December 16-18, 2005. With the advent of VLSI system level
integration and system-on-chip, the center of gravity of the
computer industry is now moving from personal c- puting into
embedded computing. Embedded software and systems are incre- ingly
becoming a key technological component of all kinds of complex
technical systems, ranging from vehicles, telephones, aircraft,
toys, security systems, to medical diagnostics, weapons,
pacemakers, climate control systems, etc. The ICESS 2005 conference
provided a premier international forum for - searchers, developers
and providers from academia and industry to address all resulting
profound challenges; to present and discuss their new ideas, -
search results, applications and experience; to improve
international com- nication and cooperation; and to promote
embedded software and system - dustrialization and wide
applications on all aspects of embedded software and systems.
Challenges in Design and Implementation of Middlewares for
Real-Time Systems brings together in one place important
contributions and up-to-date research results in this fast moving
area. Challenges in Design and Implementation of Middlewares for
Real-Time Systems serves as an excellent reference, providing
insight into some of the most challenging research issues in the
field.
The main objectives of the book are to introduce the design method
of boundary control strategies for the axially moving structures to
reduce their vibration. This book provides the reader with a
thorough grounding in the boundary controller design. Our goal is
to provide advanced boundary controller design methods and their
stability analysis methods and offer simulation examples and MATLAB
programs for each boundary control algorithm. For each chapter,
several engineering application examples are given and the contents
of each chapter in this book are independent, so that readers can
just read their own needs. In this book, all the control algorithms
and their programs are described separately and classified by the
chapter name, which can be run successfully in MATLAB. The book can
benefit researchers, engineers, and graduate students in the fields
of PDE modeling and boundary vibration control of flexible
structures.
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Big Data - 9th CCF Conference, BigData 2021, Guangzhou, China, January 8-10, 2022, Revised Selected Papers (Paperback, 1st ed. 2022)
Xiangke Liao, Wei Zhao, Enhong Chen, Nong Xiao, Li Wang, …
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R2,464
Discovery Miles 24 640
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Ships in 10 - 15 working days
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This book constitutes the proceedings of the 9th CCF Conference on
Big Data, BigData 2021, held in Guangzhou, China, in January 2022.
Due to the COVID-19 pandemic BigData 2021 was postponed to 2022.
The 21 full papers presented in this volume were carefully reviewed
and selected from 66 submissions. They present recent research on
theoretical and technical aspects on big data, as well as on
digital economy demands in big data applications.
Since the reform and opening-up in the late 1970s, Wenzhou City of
China's Zhejiang Province has witnessed large-scale institutional
change and rapid economic development. This book studies the
institutional change and economic development in Wenzhou since
China's reform and opening-up. It concludes that the most important
characteristic of Wenzhou model is that the city is the first to
promote industrialization and urbanization by privatization and
marketization in Zhejiang. As privatization and marketization
reflect reform, and industrialization and urbanization represent
development, Wenzhou model promotes development through economic
reform. In the early years of the reform and opening-up, the people
of Wenzhou boldly faced the constraints of traditional planned
economy, bravely explored the market-oriented reform and opened up
a new path to regional economic development. This book also
contains the stories of the people of Wenzhou.
As an area of research that continues to develop, the study of
linguistics worldwide presents the opportunity for the improvement
of cross-cultural communication through education and research.
Language educators are charged with the task of instructing
students to effectively communicate across cultures in a
multi-lingual word. The Handbook of Research on Teaching Methods in
Language Translation and Interpretation presents an
interdisciplinary approach to educational contexts across cultures
for the study of verbal and written linguistics in order to broaden
students' communicative and problem solving abilities. This book is
an essential reference source for academicians, researchers,
professionals, and students in the fields of education and
linguistics, interested in the assessment and evaluation of
pedagogical research to enhance learning methodologies and
practices.
This book examines the features and proposals of residential
covered bond utilization and future issues for the 112th Congress.
Covered bonds are a relatively common method of funding mortgages
in Europe, however uncommon in the United States. A covered bond is
a recourse debt obligation that is secured by a pool of assets,
often mortgages. The holders of the bond are given additional
protection in the event of bankruptcy or insolvency of the issuing
lender. Because some believe that the sub-prime mortgage turmoil
may have been influenced by poor incentives for lenders using the
securitization process, some policymakers have recommended covered
bonds as an alternative for U.S. mortgage markets. Although covered
bond contracts are not prohibited in the U.S., some policymakers
believe that legislation and agency rulemaking could facilitate the
growth of a domestic covered bond market.
Computer networks need novel communication theory for transmitting
data from sources to destinations within a predetermined restrict
period of time according to a given quality of service (QoS). This
book provides an analysis of min-plus algebra that is applied to
network calculus in computer networks. The key contribution of this
book is to discuss the analytical expressions of identity in
min-plus algebra. Overall, this book can be used as a reference for
researchers, engineers and postgraduates in the fields of
communication networks, internet studies and cyber-physical
networking systems in the aspect of applied functional analysis, in
addition to min-plus algebra used in network calculus for computer
scientists.
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The Telecommunications Handbook (Hardcover)
Kornel Terplan, Patricia A. Morreale; Contributions by Henry W. Owen, Izhak Rubin, Wei Zhao, …
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R5,354
R4,473
Discovery Miles 44 730
Save R881 (16%)
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Ships in 12 - 17 working days
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A panel of renowned experts from around the world contributed to this authoritative handbook that covers the essential aspects of this most dynamic field of communications and networking activity. Edited by Dr. Kornel Terplan and Patricia Morreale - well known authorities in telecommunications- this important new handbook provides basic principles and definitions, details the tremendous advances in technology, outlines implementation techniques, and discusses the outstanding issues and key challenges faced by communications and networking specialists. The telecommunications topics addressed include: o Basic principles o Services on broadband networks o Signal processing and coding schemes o Mobile and wireless networks o DSL technologies o Digital video and multimedia o Quality of service o Regulation o Standards o Emerging technologies Exhaustive in scope and packed with diagrams, tables, and illustrations, The Telecommunications Handbook is an indispensable, detailed reference for engineers, analysts, managers, and students involved in a wide range of telecommunication and networking activities.
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