Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

This book explores federal health care support programs that have been instituted to treat children that are deaf and hard of hearing and to improve children's dental services and oral health care, as well as medical care programs for children with Down Syndrome and their special health care concerns. The federal government supports these children through the Early Hearing Detection and Intervention (EHDI) program, which awards grants to states to develop systems to screen and diagnose new-borns and infants for hearing loss. The Children's Health Insurance Program Reauthorization Act of 2009 studies children's access to dental care; and the Prenatally and Postnally Diagnosed Conditions Awareness Act focuses on the effectiveness of current health care and family support programs for the families of children with disabilities.

Electronic skins are critical for many applications in human-machine-environment interactions. Tactile sensitivity over large areas can be especially applied to prosthetics. Moreover, the potential for wearables, interactive surfaces, and human robotics have propelled research in this area. In this Element, we provide an account and directional atlas of the progress in materials and devices for electronic skins, in the context of sensing principles and skin-like features. Additionally, we give an overview of essential electronic circuits and systems used in large-area tactile sensor arrays. Finally, we present the challenges and provide perspectives on future developments.