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Recent innovations, including deep brain stimulation and new
medications, have significantly improved the lives of people who
have Parkinson's disease. Nevertheless, patients and families
continue to face many challenges. They have long relied on this
book for reliable advice about medical, emotional, and physical
issues. Bringing this trusted guide up to date, three expert
neurologists describe: new understandings gained by five years of
additional research on Parkinson's disease; new focus on the
importance of exercise; new information about imaging techniques
such as SPECT Scan and DATScan that are aiding in the diagnosis;
new findings about the genetics of the disease; promising uses of
new technologies such as tablet devices for people who have trouble
communicating; information about impulse control disorders caused
by some drugs used to address the symptoms of the disease; and a
complete update on treatments such as medications, surgery, and
more.
In the past five years significant progress has been made in our
basic and clinical under standing of Parkinson's disease. The
discovery that MPTP, a relatively simple molecule, is able to
induce parkinsonism in otherwise healthy adult humans, and the
recent interest in the possibility of "transplantation" procedures
as a therapeutic modality in the treatment of Parkin son's disease
have generated enormous interest in research related to Parkinson's
disease. In this setting, the National Parkinson Foundation decided
to organize a research meeting to bring together scientists
actively engaged in research relevant to the study of Parkinson's
disease, to accelerate its progress and to promote an exchange of
ideas. This meeting took place in Janu ary 1988 at Key Biscayne,
Florida. It was decided to publish the proceedings ofthis meeting
to allow rapid documentation of the participants current findings
and views regarding this rapidly of this volume follows the
organization of the meeting and begins evolving field. The
structure with a clinical and neuropathological review of current
knowledge regarding Parkinson's dis ease. Since dopaminergic
neurons playa major role in the pathophysiology of the disease,
many of the contributions relate to some aspects of dopaminergic
function including localiza tion, regulation, and pharmacology of
dopamine receptors. A special effort has been made to provide a
summary of the present knowledge of the cellular biology of the
dopaminergic neurons."
The Handbook of Clinical Neurology Vol 100: Hyperkinetic Movement
Disorders discusses hyperkinetic disorders related mainly to basal
ganglia dysfunction and pathology. It contains 13 sections and 51
chapters written by authoritative and experienced investigators and
clinicians in this extremely broad and diverse group of diseases
and syndromes. The first section on choreoathetoid diseases and
syndromes includes chapters on Huntington's disease and
Huntington's disease look-alikes; spinocerebellar degenerations;
neuroacanthocytosis; entatorubral-pallidoluysian atrophy;
neuroferritinopathy; neurodegeneration with brain iron
accumulation; mitochondrial disorders; acquired hepatocerebral
degeneration; benign hereditary chorea; and "senile chorea." The
remaining chapters focus on the abnormal involuntary movements
associated with each disease or syndrome. These include
immune-related chorea, vascular chorea, metabolic disturbances that
can induce chorea, chorea in other medical settings (e.g., postpump
chorea in children, cancer-related paraneoplastic syndromes),
myoclonus, essential tremor, and dystonia, including dystonia plus
syndromes. There are also chapters on tardive dyskinesia, unusual
clinical syndromes, and tics and stereotyped movements in children.
The text is a valuable resource for neurology and psychiatry
residents, practicing neurologists and psychiatrists, and
specialists in movement disorders.
Part of the Oxford American Neurology Library, Parkinson's Disease:
Improving Patient Care is a clinically-focused text for healthcare
professionals involved in the everyday management of Parkinson's
disease patients. Primary care physicians, general neurologists,
medical trainees, and ancillary therapists including mental health
professionals, speech therapists, and physical therapists will all
find helpful information regarding caring for patients with
Parkinson's disease. The easily readable text provides information
on the diagnosis of Parkinson's disease and everyday management of
patients with this disorder. Concise chapters and tables for easy
reference make this book easy to read in sequence or use as a handy
reference. The 12 chapters cover all aspects of Parkinson's disease
care from diagnosis, test selection and early management to
handling complications, deciding whether surgical options are
appropriate, managing Parkinson's disease patients in the inpatient
setting and supporting patients and families during late-stage
complications. Tables and boxes highlight diagnostic clues and
criteria and appropriate medications and doses for Parkinson's
disease-specific medications and medications used to treat general
aspects of the disease such as constipation.
In the past five years significant progress has been made in our
basic and clinical under- standing of Parkinson's disease. The
discovery that MPTP, a relatively simple molecule, is able to
induce parkinsonism in otherwise healthy adult humans, and the
recent interest in the possibility of "transplantation" procedures
as a therapeutic modality in the treatment of Parkin- son's disease
have generated enormous interest in research related to Parkinson's
disease. In this setting, the National Parkinson Foundation decided
to organize a research meeting to bring together scientists
actively engaged in research relevant to the study of Parkinson's
disease, to accelerate its progress and to promote an exchange of
ideas. This meeting took place in Janu- ary 1988 at Key Biscayne,
Florida. It was decided to publish the proceedings ofthis meeting
to allow rapid documentation of the participants current findings
and views regarding this rapidly of this volume follows the
organization of the meeting and begins evolving field. The
structure with a clinical and neuropathological review of current
knowledge regarding Parkinson's dis- ease. Since dopaminergic
neurons playa major role in the pathophysiology of the disease,
many of the contributions relate to some aspects of dopaminergic
function including localiza- tion, regulation, and pharmacology of
dopamine receptors. A special effort has been made to provide a
summary of the present knowledge of the cellular biology of the
dopaminergic neurons.
Recent innovations, including deep brain stimulation and new
medications, have significantly improved the lives of people with
Parkinson's disease. Nevertheless, medical, emotional, and physical
challenges remain. The second edition of this accessible and
comprehensive guide provides crucial information for managing this
complex condition, including details on the use of medications,
diet, exercise, complementary therapies, and surgery. The second
edition includes new information about: * The genetic and
hereditary pattern of the disease * Medications and uses of
established medications * Other approaches to treating the symptoms
of Parkinson's * Juvenile-onset Parkinson's disease * Normal
pressure hydrocephalus * The effects of fluctuating hormones on
disease symptoms * Fetal cell transplants and porcine cell
transplants * The nutritional supplement Co-Enzyme Q10
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