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Marine organisms produce a wide array of toxins, many of which are
not only structurally unusual, but also show potent and interesting
modes of action. Since the discovery of tetrodotoxin, a pufferfish
toxin, as a potent and selective blocker of Na+ channels in 1964,
it has been widely used as a research tool in pharmacological and
physiological research. This has led to the identification of a
number of important biological functions for Na+ channels. In
recent years, much biological research has been carried out at
molecular and cellular levels, and therefore selective inhibitors
of enzymes and selective antagonist/agonists of receptors and
channels have become increasingly important research tools.
Accordingly, interest in using such compounds as reagents has
increased. Marine toxins are some of the most popular research
tools and have already contributed much to our understanding of
biological processes and disease mechanisms. Written for:
Scientists, researchers, pharmacologists
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