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This book, written by experienced geneticists, covers topics
ranging from the natural history of the mouse species, its handling
and reproduction in the laboratory, and its classical genetics and
cytogenetics, to modern issues including the analysis of the
transcriptome, the parental imprinting and X-chromosome
inactivation. The strategies for creating all sorts of mutations,
either by genetic engineering or by using mutagens, are also
reviewed and discussed in detail. Finally, a last chapter outlines
the methodology used for the analysis of complex or quantitative
traits. The authors also discuss the importance of accurate
phenotyping, which is now performed in the mouse clinics
established worldwide and identify the limits of the mouse model,
which under certain circumstances can fail to present the phenotype
expected from the cognate condition in the human model. For each
chapter an up-to-date list of pertinent references is provided. In
short, this book offers an essential resource for all scientists
who use or plan to use mice in their research.
This book, written by experienced geneticists, covers topics
ranging from the natural history of the mouse species, its handling
and reproduction in the laboratory, and its classical genetics and
cytogenetics, to modern issues including the analysis of the
transcriptome, the parental imprinting and X-chromosome
inactivation. The strategies for creating all sorts of mutations,
either by genetic engineering or by using mutagens, are also
reviewed and discussed in detail. Finally, a last chapter outlines
the methodology used for the analysis of complex or quantitative
traits. The authors also discuss the importance of accurate
phenotyping, which is now performed in the mouse clinics
established worldwide and identify the limits of the mouse model,
which under certain circumstances can fail to present the phenotype
expected from the cognate condition in the human model. For each
chapter an up-to-date list of pertinent references is provided. In
short, this book offers an essential resource for all scientists
who use or plan to use mice in their research.
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