This is the first book ever published on the problems of true triaxial testing of rocks addressing all aspects of true triaxial testing of rocks, including: (i) true triaxial testing techniques and procedures; (ii) test results: strength, deformability, failure mode, permeability, acoustic emission, and elastic wave velocity; (iii) constitutive laws and failure criteria; and (iv) applications to geoengineering and geosciences. Recent developments in the field of true triaxial testing of rocks are presented, as well as a thorough review of the most important achievements in the whole history of true triaxial testing of rocks. Almost all researchers from around the world engaged in the true triaxial testing of rocks over the last three decades have contributed to this work. The authors originate from different branches of geoengineering and geosciences, including civil engineering, engineering geology, geotechnical engineering, mining engineering, petroleum engineering, seismology, and tectonophysics.

This is the first English book that presents a professional analysis of the recent dynamic movement of the Chinese economy by focusing on the Yangtze River Delta region, which is the main engine of the Chinese economy. The impact of the international financial crisis on China’s economic development requires a change from the first wave of economic globalization oriented toward exports to the second wave of economic globalization characterized by expanding domestic demand. Taking this economic aspect into consideration, the following are proposed in this book: 1) expansion of the level of openness in the process of increasing domestic demand means shifting the industrial focus from manufacturing to the service industry; 2) promotion of the globalization of local services should be based on the globalization of local manufacturing; 3) the Yangtze River Delta region should aim at its own strategic positioning under new, changed circumstances and should achieve modernization in advance with the concept of integrative development; 4) Establishment of a support system is essential meanwhile for this area to develop an innovative economy and to promote the transition from manufacturing to promoting emerging industries, including a modern service industry. The book has an underlying concept, namely, that the key to economic transformation is to start the development of modern services and that only by transforming the development pattern of the service industry can the transition and upgrade of the economy be effectively achieved. For this purpose further urbanization and advancing the transformation from low-tech to high-tech industries by the effective development of industrial clusters is advocated. To ensure that these conclusions are based on a solid analysis, the authors draw heavily upon empirical analyses employing modern econometric methods and make use of economic theories such as endogenous growth theory and spatial economic theory.     

This is the first English book that presents a professional analysis of the recent dynamic movement of the Chinese economy by focusing on the Yangtze River Delta region, which is the main engine of the Chinese economy. The impact of the international financial crisis on China's economic development requires a change from the first wave of economic globalization oriented toward exports to the second wave of economic globalization characterized by expanding domestic demand. Taking this economic aspect into consideration, the following are proposed in this book: 1) expansion of the level of openness in the process of increasing domestic demand means shifting the industrial focus from manufacturing to the service industry; 2) promotion of the globalization of local services should be based on the globalization of local manufacturing; 3) the Yangtze River Delta region should aim at its own strategic positioning under new, changed circumstances and should achieve modernization in advance with the concept of integrative development; 4) Establishment of a support system is essential meanwhile for this area to develop an innovative economy and to promote the transition from manufacturing to promoting emerging industries, including a modern service industry. The book has an underlying concept, namely, that the key to economic transformation is to start the development of modern services and that only by transforming the development pattern of the service industry can the transition and upgrade of the economy be effectively achieved. For this purpose further urbanization and advancing the transformation from low-tech to high-tech industries by the effective development of industrial clusters is advocated. To ensure that these conclusions are based on a solid analysis, the authors draw heavily upon empirical analyses employing modern econometric methods and make use of economic theories such as endogenous growth theory and spatial economic theory.

Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

This is the first book ever published on the problems of true triaxial testing of rocks addressing all aspects of true triaxial testing of rocks, including: (i) true triaxial testing techniques and procedures; (ii) test results: strength, deformability, failure mode, permeability, acoustic emission, and elastic wave velocity; (iii) constitutive laws and failure criteria; and (iv) applications to geoengineering and geosciences.

Recent developments in the field of true triaxial testing of rocks are presented, as well as a thorough review of the most important achievements in the whole history of true triaxial testing of rocks.

Almost all researchers from around the world engaged in the true triaxial testing of rocks over the last three decades have contributed to this work. The authors originate from different branches of geoengineering and geosciences, including civil engineering, engineering geology, geotechnical engineering, mining engineering, petroleum engineering, seismology, and tectonophysics.