Hedgehog Signaling - Methods and Protocols (Paperback, 1st ed. 2022)

This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Methods in Molecular Biology, 2374
Release date:	October 2022
Editors:	Xiaochun Li
Dimensions:	254 x 178mm (L x W)
Format:	Paperback
Pages:	244
Edition:	1st ed. 2022
ISBN-13:	978-1-07-161703-8
Categories:	Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-07-161703-6
Barcode:	9781071617038

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