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In recent years, inorganic polymers have attracted much attention
in nano-biomedicine, in particular in the area of regenerative
medicine and drug delivery. This growing interest in inorganic
polymers has been further accelerated by the development of new
synthetic and analytical methods in the field of nanotechnology and
nanochemistry. Examples for biomedical inorganic polymers that had
been proven to exhibit biomedical effects and/or have been applied
in preclinical or clinical trials are polysilicate / silica glass
(such as naturally formed "biosilica" and synthetic "bioglass") and
inorganic polyphosphate. Some members of the mentioned biomedical
inorganic polymers have already been applied e.g. as "bioglass" for
bone repair and bone tissue engineering, or they are used in food
processing and in dental care (inorganic polyphosphates). However,
there are a number of further biological and medicinal properties
of these polymers, which have been elucidated in the last few years
but not yet been applied for treatment of humans. In addition to
polysilicates and polyphosphate, there are a series of other
inorganic polymers including polyarsenate and polyvanadate, whose
biological / biomedical properties have been only marginally
studied so far. Moreover, the combined application of inorganic
polymers and organic polymeric molecules (formation of
organic-inorganic hybrid materials) provides a variety of new
materials with novel property combinations and diverse applications
in nanomedicine. The planned book summarizes the present state of
knowledge on a large group of inorganic polymers that had hitherto
been mainly considered with regard to their chemistry but not
comprehensively reviewed with respect to their potential biomedical
applications.
In recent years, inorganic polymers have attracted much attention
in nano-biomedicine, in particular in the area of regenerative
medicine and drug delivery. This growing interest in inorganic
polymers has been further accelerated by the development of new
synthetic and analytical methods in the field of nanotechnology and
nanochemistry. Examples for biomedical inorganic polymers that had
been proven to exhibit biomedical effects and/or have been applied
in preclinical or clinical trials are polysilicate / silica glass
(such as naturally formed "biosilica" and synthetic "bioglass") and
inorganic polyphosphate. Some members of the mentioned biomedical
inorganic polymers have already been applied e.g. as "bioglass" for
bone repair and bone tissue engineering, or they are used in food
processing and in dental care (inorganic polyphosphates). However,
there are a number of further biological and medicinal properties
of these polymers, which have been elucidated in the last few years
but not yet been applied for treatment of humans. In addition to
polysilicates and polyphosphate, there are a series of other
inorganic polymers including polyarsenate and polyvanadate, whose
biological / biomedical properties have been only marginally
studied so far. Moreover, the combined application of inorganic
polymers and organic polymeric molecules (formation of
organic-inorganic hybrid materials) provides a variety of new
materials with novel property combinations and diverse applications
in nanomedicine. The planned book summarizes the present state of
knowledge on a large group of inorganic polymers that had hitherto
been mainly considered with regard to their chemistry but not
comprehensively reviewed with respect to their potential biomedical
applications.
This is the first time that human organs, such as the heart, liver,
kidney, stomach, uterus, skin, lung, pancreas and breast can be
manufactured automatically and precisely for clinical
transplantation, drug screening and metabolism model establishment.
Headed by Professor Xiaohong Wang (also the founder and director)
in the Center of Organ Manufacturing, Department of Mechanical
Engineering, Tsinghua University, this group has focused on organ
manufacturing for over ten years. A series of technical bottleneck
problems, such as vascular and nerve system establishment in a
construct, multiple cell types and material system incorporation,
and stem cell sequential engagement, have been overcome one by one.
Two technical approaches have been exploited extensively. One is
multiple nozzle rapid prototyping (RP), additive manufacturing
(AM), or three-dimension (3D) printing. The other is combined mold
systems. More than 110 articles and 40 patents with a series of
theories and practices have been published consequently. In the
future, all the failed organs (including the brain) in the human
body can be substituted easily like a small accessory part in a
car. Everyone can get benefit from these techniques, which
ultimately means that the lifespan of humans, therefore, can be
greatly prolonged from this time point. This book examines the
progress made in the field and the developments made by these
researchers (and authors) in the field.
This volume focuses on the biomedical aspects of inorganic
polyphosphates, a family of unique bio-inorganic polymers. In
recent years, great advances have been made in understanding the
development, metabolism, and physiological role of inorganic
polyphosphates. These energy-rich polymers, which consist of long
chains of phosphate units, are evolutionary old molecules. The
acidocalcisomes, conserved organelles from bacteria to humans, as
well as the mitochondria play a central role in polyphosphate
production and storage. Polyphosphates have been assigned multiple
functions, some of which are closely related to medically important
processes, such as blood coagulation and fibrinolysis, energy
metabolism, cell cycle regulation, apoptosis, chaperon function,
microvascularization, stress response, neurodegeneration and aging.
The development of bioinspired polyphosphate particles, in
combination with suitable hydrogel-forming polymers enabled the
development of new strategies in regenerative medicine, in
particular for hard and soft tissue repair, but also in drug
delivery and antimicrobial defense. This book not only highlights
the basic research in this area, but also discusses possible
applications. Therefore, it appeals to scientists working in cell
biology, biochemistry, and biomedicine and practicioners alike.
This book describes the discovery of molecules from unexploited
extreme marine environments, and presents new approaches in marine
genomics. It combines the current state of knowledge in marine
genomics and advanced natural products' chemistry to pursue the
sustainable production of novel secondary metabolites (lead
compounds), as well as pharmacologically active peptides/proteins,
with antimicrobial, neuroprotective, anti-osteoporotic,
anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating
effects. Further, it employs molecular-biology-based approaches and
advanced chemical techniques to obtain and to select candidate
compounds for pre-clinical and clinical studies.
This book describes the discovery of molecules from unexploited
extreme marine environments, and presents new approaches in marine
genomics. It combines the current state of knowledge in marine
genomics and advanced natural products' chemistry to pursue the
sustainable production of novel secondary metabolites (lead
compounds), as well as pharmacologically active peptides/proteins,
with antimicrobial, neuroprotective, anti-osteoporotic,
anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating
effects. Further, it employs molecular-biology-based approaches and
advanced chemical techniques to obtain and to select candidate
compounds for pre-clinical and clinical studies.
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- (Chinese, Paperback)
Xiaohong Wang
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R568
R498
Discovery Miles 4 980
Save R70 (12%)
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Ships in 10 - 15 working days
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This book provides useful information on new observations and
therapeutic approaches to common problems encountered in strabismus
and pediatric ophthalmology. It also discusses the ocular findings
in a number of rare conditions.
All aspects of pediatric ophthalmology are addressed. The book
describes a new strabismic condition and provides updates on
research in the development of normal and abnormal monocular and
binocular vision, and in ocular motility. All different strabismus
types and their characterizations are covered, as well as nystagmus
and other ocular motor disorders. The latest advances in relevant
surgical and pharmacological management are discussed. Recent
research on diseases of the lacrimal system, the anterior segment,
cataracts, posterior segment, and neuro-ophthalmology is
extensively covered.
Update on Strabismus and Pediatric Ophthalmology presents the
proceedings of the joint meeting of the VIIth Congress of the
International Strabismological Association (ISA) and the 20th
Annual Meeting of the American Association for Pediatric
Ophthalmology and Strabismus (AAPO&S). The meeting had more
than 750 participants, making it the largest conference ever held
in the field of strabismus and pediatric ophthalmology.
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