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Inorganic Polyphosphates - From Basic Research to Medical Application (Hardcover, 1st ed. 2022)
Loot Price: R3,183
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Inorganic Polyphosphates - From Basic Research to Medical Application (Hardcover, 1st ed. 2022)
Series: Progress in Molecular and Subcellular Biology, 61
Expected to ship within 12 - 19 working days
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This volume focuses on the biomedical aspects of inorganic
polyphosphates, a family of unique bio-inorganic polymers. In
recent years, great advances have been made in understanding the
development, metabolism, and physiological role of inorganic
polyphosphates. These energy-rich polymers, which consist of long
chains of phosphate units, are evolutionary old molecules. The
acidocalcisomes, conserved organelles from bacteria to humans, as
well as the mitochondria play a central role in polyphosphate
production and storage. Polyphosphates have been assigned multiple
functions, some of which are closely related to medically important
processes, such as blood coagulation and fibrinolysis, energy
metabolism, cell cycle regulation, apoptosis, chaperon function,
microvascularization, stress response, neurodegeneration and aging.
The development of bioinspired polyphosphate particles, in
combination with suitable hydrogel-forming polymers enabled the
development of new strategies in regenerative medicine, in
particular for hard and soft tissue repair, but also in drug
delivery and antimicrobial defense. This book not only highlights
the basic research in this area, but also discusses possible
applications. Therefore, it appeals to scientists working in cell
biology, biochemistry, and biomedicine and practicioners alike.
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