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Biomaterials repair, reinforce or replace damaged functional parts
of the (human) body. All mechanical and biological interactions
between an implant and the body occur across the interface, which
has to correspond as nearly as possible to its particular function.
Much of the progress in adapting polymer materials for use in a
biological environment has been obtained through irradiation
techniques. For this reason the most recent developments in four
key areas are reviewed in this special volume: (1) the analysis of
the topology and the elemental composition of a functional surface,
(2) the chemical modification of the surface which results in
highly pure, sterile and versatile surfaces, (3) the sterilisation
of implantable devices via ionising radiation and its possible
effects on the structural mechanical properties of polymers, and
(4) the radiation effects on living cells and tissues which are of
particular importance for radiation protection and radiotherapy.
Biomaterials repair, reinforce or replace damaged functional parts of the (human) body. All mechanical and biological interactions between an implant and the body occur across the interface, which has to correspond as nearly as possible to its particular function. Much of the progress in adapting polymer materials for use in a biological environment has been obtained through irradiation techniques. For this reason the most recent developments in four key areas are reviewed in this special volume: (1) the analysis of the topology and the elemental composition of a functional surface, (2) the chemical modification of the surface which results in highly pure, sterile and versatile surfaces, (3) the sterilisation of implantable devices via ionising radiation and its possible effects on the structural mechanical properties of polymers, and (4) the radiation effects on living cells and tissues which are of particular importance for radiation protection and radiotherapy.
The scope of this book deals with biosensors and microarrays that
take advantage of the specific biological recognition between a
surface-immobilised "probe" and a biological "target" in solution.
In order to preserve the integrity of the biological interaction
taking place on a sensor, surface immobilisation of the probe
should guarantee the preservation of the probe conformation,
orientation and availability. Herein, we will first give a brief
definition of biosensors and their requirements. The use of
organosilanes as anchoring layers for biomolecules on different
materials is then discussed. Finally, the biofunctionalisation of
organosilanes and their applications are described.
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