The first useful antibiotic found by screening was streptomycin. The late Prof. WAKSMAN started screening for antibacterial antibiotics in 1940 and, after finding actinomycin in 1941, he and his collaborators discovered streptomycin in 1944. This antibiotic made a great contribution in saving human lives from tuberculosis and acute serious infections. About 1957, after wide usage of such antibiotics as penicillin, streptomycin, chloramphenicol, tetracycline, and erythromycin, staphy- lococci and Gram negative organisms resistant to all or most antibiotic drugs ap- peared in hospital patients. The origin and treatment of such resistant strains be- came a major topic of investigation. At that time, kanamycin was discovered and used in the treatment of resistant infections. It may be said that the appearance of resistant strains stimulated a resurgence of research on new antibacterial antibiot- ics and their derivatives. In 1965, kanamycin-resistant strains were found in hospital patients and, undertaking the study of the mechanisms of resistance, I found that resistant strains produce intracellular enzymes that can transfer either the terminal phos- phate of ATP or the acetate of acetyl-CoA to the 3' -hydroxyl or the 6' -amino group of 2-deoxystreptamine~containing antibiotics. These results, reported in 1967, made it possible to design new synthetic derivatives that would inhibit the growth of kanamycin resistant strains of microorganisms. Thus, a new research area was opened: the development of aminoglycosides useful in the treatment of drug-resis- tant infections.

New macromolecular concepts and strategies are demonstrated in this unique book. It deals with the harmonization of humanity in science, technology and industry. Particular attention is given to the relationship between the sensitivity of the human mind and the functionality of polymers such as "Shingosen." Moreover, biocompatibility of functional polymers for medical applications and fabrics is discussed as one of the prime examples of human creativity. Lessons of conventional wisdom of traditional Japanese shrine carpenters, which originated 1300 years ago in Horyuji Temple in Nara Japan, can be applied to modern business management by entrepreneurs and in high-tech industries.

For a company to survive in the manufacturing industry, it must not only accumulate light-weight 3D data, but also share this information within the company and with related companies as well as train key personnel. 3D Manufacturing Innovation introduces the best practices developed by Toyota, Sony, Nikon, Casio and other pioneers in the global engineering scene, providing the reader with invaluable tips for manufacturing innovation.

3D design is now a key technology for effective collaboration between manufacturing companies. Since the introduction of light-weight 3D data technology, "post-3D CAD/CAM/CAE data" is now compatible for use across manufacturing, sales and marketing processes. The successful use of 3D data throughout such processes has become indispensable for the competitive strength of companies in the manufacturing industry.

For a company to survive and win in the manufacturing industry, it must not only accumulate light-weight 3D data, but also share this information within the company and with related companies, and train key personnel in the use of this data. 3D Manufacturing Innovation introduces the best practices developed by Toyota, Sony, Nikon, Casio and other pioneers in the global engineering scene, providing the reader with invaluable tips for manufacturing innovation.

3D Manufacturing Innovation is a valuable guide for corporate IT managers, consultants and professionals involved in CAD/CAM/CAE, as well as to vendors of digital engineering software.

This 1980 book considers the patterns of population fluctuations of animals and intraspecific social relations by means of comparative methods and discusses the evolution of population regulation mechanisms and social relations. The author proposes that parental care has evolved in environments in which it is difficult for the young to obtain food, whilst high fecundity has evolved in the opposite environment. He presents evidence from a wide range of organisms to argue that during evolution animals repeatedly face the 'choice' of two strategies - low fecundity combined with parental protection, or high fecundity - and that this choice determined the amplitude, regularity and associated main factors of population fluctuations as well as the main characteristics of social relations as expressed in group life or dispersed living involving territory. Although many examples are drawn from insects, with which the author is most familiar, mammal, birds and other animal groups are also examined in depth.

This 1980 book considers the patterns of population fluctuations of animals and intraspecific social relations by means of comparative methods and discusses the evolution of population regulation mechanisms and social relations. The author proposes that parental care has evolved in environments in which it is difficult for the young to obtain food, whilst high fecundity has evolved in the opposite environment. He presents evidence from a wide range of organisms to argue that during evolution animals repeatedly face the 'choice' of two strategies - low fecundity combined with parental protection, or high fecundity - and that this choice determined the amplitude, regularity and associated main factors of population fluctuations as well as the main characteristics of social relations as expressed in group life or dispersed living involving territory. Although many examples are drawn from insects, with which the author is most familiar, mammal, birds and other animal groups are also examined in depth.