Aminoglycoside Antibiotics (Paperback, Softcover reprint of the original 1st ed. 1982)

The first useful antibiotic found by screening was streptomycin. The late Prof. WAKSMAN started screening for antibacterial antibiotics in 1940 and, after finding actinomycin in 1941, he and his collaborators discovered streptomycin in 1944. This antibiotic made a great contribution in saving human lives from tuberculosis and acute serious infections. About 1957, after wide usage of such antibiotics as penicillin, streptomycin, chloramphenicol, tetracycline, and erythromycin, staphy- lococci and Gram negative organisms resistant to all or most antibiotic drugs ap- peared in hospital patients. The origin and treatment of such resistant strains be- came a major topic of investigation. At that time, kanamycin was discovered and used in the treatment of resistant infections. It may be said that the appearance of resistant strains stimulated a resurgence of research on new antibacterial antibiot- ics and their derivatives. In 1965, kanamycin-resistant strains were found in hospital patients and, undertaking the study of the mechanisms of resistance, I found that resistant strains produce intracellular enzymes that can transfer either the terminal phos- phate of ATP or the acetate of acetyl-CoA to the 3' -hydroxyl or the 6' -amino group of 2-deoxystreptamine~containing antibiotics. These results, reported in 1967, made it possible to design new synthetic derivatives that would inhibit the growth of kanamycin resistant strains of microorganisms. Thus, a new research area was opened: the development of aminoglycosides useful in the treatment of drug-resis- tant infections.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Handbook of Experimental Pharmacology, 62
Release date:	November 2011
First published:	1982
Editors:	Hamao Umezawa
Contributors:	Irving R. Hooper • Y. Ito
Editors:	Irving R. Hooper
Contributors:	T Koeda • S Kondo • S. Mitsuhashi • T. Okuda • N Tanaka • T. Tsuchiya
Dimensions:	244 x 170 x 20mm (L x W x T)
Format:	Paperback
Pages:	372
Edition:	Softcover reprint of the original 1st ed. 1982
ISBN-13:	978-3-642-68581-1
Categories:	Books > Medicine > Nursing & ancillary services > Pharmacy / dispensing Books > Medicine > Other branches of medicine > Pharmacology > General Promotions
LSN:	3-642-68581-1
Barcode:	9783642685811

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!