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The 10th International Winter Conference on Neurodegeneration
(lWCN) has taken place from February 14-16,2002, at the lovely
"SchloB Ziethen", an old prussian manor (in Prussia, 'faute de
mieux', called 'SchloB', i. e. cas- tle or residence). This place
is 20 km off Tegel Airport, Berlin's main airport, and has been
beautifully restored by baroness Edith von Thiingen (nee von BUlow,
i. e. of historical Prussian aristocracy); it lends itself rather
perfectly for the IWCN type of small interdisciplinary workshops on
neurodegenera- tion which combine short lectures with plenty of
discussion. In this context, we could quote Alexander von
Humboldt's famous opening words for one of the first international
scientific meetings held at Berlin, on September 18, 1828: "The
main purpose ...does not consist in a mutual reading of manuscripts
all to be printed after at least one year in specialised
publications, but in the personal communication amongst those who
work in similar scientific fields; the oral and thus more
stimulating exchange of ideas, might they represent facts, opinions
or doubts; the foundation of friendly relations which convey
illumination to our sciences, serene grace to our lives and
tolerance and mildness to our habits . ..Berlin, Sept. 18, 1828
Alexander von Humboldt To the IWCN aficionado, it may come as a
little surprise that this is the pub- lication of the 10th Winter
Conference as this might mean that they must have missed number 9.
The 10th International Winter Conference on Neurodegeneration
(lWCN) has taken place from February 14-16,2002, at the lovely
"SchloB Ziethen," an old prussian manor (in Prussia, 'faute de
mieux', called 'SchloB', i. e. cas tle or residence). This place is
20 km off Tegel Airport, Berlin's main airport, and has been
beautifully restored by baroness Edith von Thiingen (nee von BUlow,
i. e. of historical Prussian aristocracy); it lends itself rather
perfectly for the IWCN type of small interdisciplinary workshops on
neurodegenera tion which combine short lectures with plenty of
discussion. In this context, we could quote Alexander von
Humboldt's famous opening words for one of the first international
scientific meetings held at Berlin, on September 18, 1828: "The
main purpose . . . does not consist in a mutual reading of
manuscripts all to be printed after at least one year in
specialised publications, but in the personal communication amongst
those who work in similar scientific fields; the oral and thus more
stimulating exchange of ideas, might they represent facts, opinions
or doubts; the foundation of friendly relations which convey
illumination to our sciences, serene grace to our lives and
tolerance and mildness to our habits . . . Berlin, Sept. 18, 1828
Alexander von Humboldt To the IWCN aficionado, it may come as a
little surprise that this is the pub lication of the 10th Winter
Conference as this might mean that they must have missed number 9."
The 8th International Winter Conference on Neurodegeneration from
Febru- ary 9 to 13, 2000 took place in Tegernsee, Bavaria, Germany.
The interest shown in this symposium, which was carried by invited
speakers only, was striking. 28 lectures in 5 sessions dealt with
themes on basic science and therapy strategies for
neurodegenerative illness. This time especially basic mechanism of
cell death and resulting causal treatment possibilities were centre
themes of the lectures and lively discussions. In accordance with
tradi- tion 5 lectures on Multiple Sclerosis finished the
convention. 60 scientists from 13 countries discussed current
questions to these themes. The Symposium started with a lecture on
the history of the develop- ment of modern-L-DOPA-therapy. Lectures
on cell death of dopaminergic nerve cells, new valuation regarding
assembly, built up and function of neuromelanin of Substantia nigra
and with this, the question of the physio- logic and
pathobiochemical role of dopamine and neuromelanin built the first
block of themes which consequently extended to molecular and
genetic aspects of cell death. Highlights of the symposium were
neuroprotective and neuroregenerative future therapy strategies
together with discussions on the difficulties of clinical
neuroprotection. Developmental biological aspects on nerve cells,
reorganisation and neurodegeneration showed a stimulating point of
view of momentary and future development possibilities of new and
more causal forms of therapy of neurodegenerative illness.
Volume 5 of the series "Advances in Research on Neurodegeneration"
is concerned with themes which are currently the focus of intensive
research, and in which advances in our understanding of the
pathological mechanisms un derlying neurodegenerative diseases are
expected in the near future. The first section contains five
reviews devoted to the various neuroimaging technolo gies. The
discussion is concerned with the question of whether neuroimaging
techniques make it possible to follow the process of degeneration
as it occurs, and which methods offer the required sensitivity and
quantifiability for this purpose. However, the question needs to be
examined of whether, given the physical and chemical limitations of
these techniques, even under optimal conditions, anatomical
resolution can be improved to the extent that neuro degenerative
diseases can be diagnosed earlier than currently possible and a
confident diagnosis made. The possibilities of using neuroimaging
techniques to provide information regarding the effects of
neuroprotective or neuroregen erative therapeutic strategies, and
for correlating the results of neuropsycho logical research with
imaging data are also discussed. The second section is concerned
with the significance of endogenous or exogenous neurotoxins as
triggers for neurodegenerative processes that may lead to
Parkinsonism. Vulnerability factors, which include such factors as
nerve ending sensitivity, the synergistic effects of drugs and the
various mechanisms underlying different toxins are discussed."
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