This book describes a comprehensive framework for hardware/software co-design, optimization, and use of robust, low-cost, and cyberphysical digital microfluidic systems. Readers with a background in electronic design automation will find this book to be a valuable reference for leveraging conventional VLSI CAD techniques for emerging technologies, e.g., biochips or bioMEMS. Readers from the circuit/system design community will benefit from methods presented to extend design and testing techniques from microelectronics to mixed-technology microsystems. For readers from the microfluidics domain, this book presents a new design and development strategy for cyberphysical microfluidics-based biochips suitable for large-scale bioassay applications. * Takes a transformative, "cyberphysical" approach towards achieving closed-loop and sensor feedback-driven biochip operation under program control; * Presents a "physically-aware" system reconfiguration technique that uses sensor data at intermediate checkpoints to dynamically reconfigure biochips; * Enables readers to simplify the structure of biochips, while facilitating the "general-purpose" use of digital microfluidic biochips for a wider range of applications.

With its virtually universal treaty network and its binding dispute settlement mechanism (DSM), has the World Trade Organization (WTO) become a legalizedA" international organization? To a large extent, the positive effect of the move to a higher level of legalization in the WTO is commonly acknowledged. Nevertheless, contrary to the high expectations of trade 'legalists', empirical studies suggest that the policy goal of trade liberalization cannot always be achieved by the functioning of the WTO legal system. Indeed, legalization at the international level often affects domestic systems in ways that are not only unintended, but often provoke unanticipated reactions. This incisive new study analyzes the proliferation of legalization in the WTO and two vital aspects of its consequences. The author illustrates the rise of legalization in the trade regime by examining the pragmatic process of legalization and its consequences in the field of anti-dumping. She particularly sketches the historical development of legalization in the multilateral anti-dumping framework by identifying significant events which illustrate the increased obligation, greater precision, and stronger delegation in the regime. She then explores the impact of international legalization on the EU's anti-dumping regime and China's dispute settlement activities in this area since the country's relatively recent accession. She demonstrates that, even after decades of legalization, domestic anti-dumping investigations often fail to fulfil the expectations of global legalists, and that the results of those investigations are not always challengeable in the DSM. The author's focus brilliantly illuminates two features of the role of legalization played in the development of the WTO system that are widely discussed: (1) the correlation between legalization in GATT/WTO law and corresponding changes in domestic policy-making, policy administration, and judicial review; and (2) the impact of legalization on the utilization of the DSM to settle disputes in particular subject areas. Concluding that the evolution of the GATT/WTO system is an illustrative example of the phenomenal rise of legalization in international organizations, the book is a valuable contribution to the broader debate of 'constitutionalization' in the international economic law literature. This is the first study to systematically analyze the rise of legalization in the WTO and its impact on domestic systems in this context. In its analysis of the discourse, dynamics, and effects of legalization in the trade regime, and in its empirical examples, this book will prove of great value to all professionals, legal or otherwise, involved with international trade and the economics of globalization.