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Aging can be perceived differently during different times in one's
life. Aging as a process not only influences medical and economic
dimensions at an individual level but also at societal and national
levels. Aging is a natural process; however, its standard
definition in a healthcare context is yet unclear. To delay the
aging process and to maintain quality of life until the end of life
are two goals of prime importance. Various healthcare approaches
are being developed and experimented on to best manage aging as if
it is a disease. Nutraceuticals are value-added dietary supplement
products and have an immense potential in altering key structures
and functions of aging. Nutraceuticals can be a keystone in
altering sub-normal performing physiological and metabolic systems
due to aging. Nutraceuticals for Aging and Anti-Aging: Basic
Understanding and Clinical Evidence addresses aging and anti-aging
nutraceuticals based on 10 major challenges, such as cognitive
health, malnutrition, substance abuse, bladder control, and oral
health, among others. It examines how these challenges can be
complemented with nutraceuticals and connects the applications with
the traditional wisdom of the aging process. Key Features Examines
the aging process, then recommends nutraceuticals for aging and
anti-aging processes Describes the aging process from the western
perspective, and Ayurvedic medicine (Indian traditional system) and
traditional Chinese medicine perspectives Provides, whenever
possible, the clinical evidence of the applications of
nutraceuticals for aging and anti-aging This book is a valuable
resource for physicians, clinical experts, pharmaceutical companies
and their experts, nutrition specialists, entrepreneurs, chemists,
pharmacists, food chemists-technologists, as well as researchers
and post-graduate students involved in these specialties. Also
available in the Nutraceuticals: Basic Research/Clinical
Applications Series: Bioactive Peptides: Production,
Bioavailability, Health Potential, and Regulatory Issues, edited by
John O. Onuh, M. Selvamuthukumaran, and Yashwant V. Pathak (ISBN:
978-0-3675-1177-7) Nutraceuticals for Prenatal, Maternal and
Offspring's Nutritional Health, edited by Priyanka Bhatt, Maryam
Sadat Miraghajani, Sarvadaman Pathak, and Yashwant V. Pathak (ISBN
978-1-1383-4582-9) Advances in Nutraceutical Applications in
Cancer: Recent Research Trends and Clinical Applications, edited by
Sheeba Varghese Gupta, and Yashwant V. Pathak (ISBN
978-1-1385-9391-6)
With the advent of analytical techniques and capabilities to
measure particle sizes in nanometer ranges, there has been
tremendous interest in the use of nanoparticles for more efficient
methods of drug delivery. Nanoparticulate Drug Delivery Systems
addresses the scientific methodologies, formulation, processing,
applications, recent trends, and emerging technologies in the
research of nanoparticulate drug delivery systems (NPDDS). It
extensively covers applications of NPDDS- including lipid
nanoparticles for dermal applications; nanocarriers for the
treatment of restenosis; and for ocular, central nervous system,
and gastrointestinal applications. It also explores its use as an
adjuvant for vaccine development. Supplying insight from
international experts, this guide Discusses formulation for poorly
soluble drugs Presents biological requirements for nanotherapeutic
applications Demonstrates the role of nanobiotechnology in the
development of nanomedicine Documents recent advances in
nanoparticulate technology-including electrospining, formation of
microcrystals, and production of liquid crystalline phases Examines
the technology of metallic nanoparticles
Due in part to an absence of universally accepted standardization
methods, nutraceuticals and functional foods face regulatory
ignorance, marketing incompetence and ethical impunity. Even though
many researchers believe that there is a connection between
nutraceuticals and functional foods and reduced health care
expenses as well as disease prevention, the credibility and quality
control challenge remains. The industry needs more standardized
testing, reliable reproducible clinical studies to prove the
efficacies of products in vivo, and in-process controls to maintain
universal product quality. The first volume of the Handbook of
Nutraceuticals re-defined Nutraceuticals, covering the regulatory
aspect as well as insisting on the cGMP's and SOP's for the
nutraceutical manufacturing. This second volume focuses on the
scale up, processing, and automation of nutraceutical production
under cGMP production regulations. It covers: Advancements in
extraction methods Unit operations involved in scaling up and
processing Rheological and flow properties of products as
characterization parameters Fortification and value enhancement
using nanotechnology Green concepts in food industry Flavoring of
nutraceuticals Clinical batch nutraceutical manufacturing New
technologies to prevent counterfeiting Automation in nutraceutical
industry The nutraceutical market is at the crossroads. With a
nearly $200 billion market for nutraceuticals and functional foods
by end of 2013, and promising developments in product design and
discovery, the industry must be ready for intense scrutiny. The
standardization of testing, clinical studies, and adherence to
rigorous industry and scientific methods is necessary for the
advancement, acceptance, and development of high quality, effective
nutraceuticals. With contributions from leading authorities, this
book brings together hundreds of years of combined experience to
provide guidance on how to increase the quality and credibility of
nutraceutical products.
The nutritional and medicinal value of metals, such as zinc,
calcium, and iron, has been known in traditional medicine for a
long time. Other metals, such as silver and gold, may also have
therapeutic and health benefits. Ancient medicines have long
incorporated their use in the treatment of diseases, and they have
also more recently been explored for treatment in allopathic
medicine, birthing the concept of metallonutraceuticals. The
challenge of using metals in the human body is to find forms that
are safe and effective. Handbook of Metallonutraceuticals presents
basic concepts related to the nutritional and therapeutic use of
metals, product development strategies, and some ideas ready to be
applied for condition-specific metallonutraceuticals. The book
begins with an overview of the nutraceuticals field and the need
for metallonutraceuticals. It considers the roles of various metals
in metabolism, reviews the ethnopharmacology and ethnomedicine of
metals, and covers the characterization and possible properties of
metallonutraceuticals. It also examines bioavailability and drug
interactions, and therapeutic applications of nanometals including
use as imaging agents, in cancer diagnosis and treatment, as
antibacterials and antivirals, in ocular disease, and in
neurodegenerative diseases. The book explores the use of metals in
traditional Chinese medicine, potential applications for
metalloenzymes, the use of nanosilver in nutraceuticals, and the
potential of gold nanoparticles as a drug delivery system. In
addition, it addresses intellectual property rights and regulatory
considerations regarding metallonutraceuticals. Using an
interdisciplinary approach, this user-friendly text provides a
knowledge base and inspiration for new research in this exciting
field.
Due in part to an absence of universally accepted standardization
methods, nutraceuticals and functional foods face regulatory
ignorance, marketing incompetence and ethical impunity. Even though
many researchers believe that there is a connection between
nutraceuticals and functional foods and reduced health care
expenses as well as disease prevention, the credibility and quality
control challenge remains. The industry needs more standardized
testing, reliable reproducible clinical studies to prove the
efficacies of products in vivo, and in-process controls to maintain
universal product quality. The first volume of the Handbook of
Nutraceuticals re-defined Nutraceuticals, covering the regulatory
aspect as well as insisting on the cGMP's and SOP's for the
nutraceutical manufacturing. This second volume focuses on the
scale up, processing, and automation of nutraceutical production
under cGMP production regulations. It covers: Advancements in
extraction methods Unit operations involved in scaling up and
processing Rheological and flow properties of products as
characterization parameters Fortification and value enhancement
using nanotechnology Green concepts in food industry Flavoring of
nutraceuticals Clinical batch nutraceutical manufacturing New
technologies to prevent counterfeiting Automation in nutraceutical
industry The nutraceutical market is at the crossroads. With a
nearly $200 billion market for nutraceuticals and functional foods
by end of 2013, and promising developments in product design and
discovery, the industry must be ready for intense scrutiny. The
standardization of testing, clinical studies, and adherence to
rigorous industry and scientific methods is necessary for the
advancement, acceptance, and development of high quality, effective
nutraceuticals. With contributions from leading authorities, this
book brings together hundreds of years of combined experience to
provide guidance on how to increase the quality and credibility of
nutraceutical products.
As soon as Dr. Stephen DeFelice coined the phrase nutraceutical,
product and supplement developers swung into action. Yet among the
numerous books available on nutraceuticals, there is none that
systematically lists, categorizes, and analyzes nutraceutical
extracts and formulations in a pharmacopoeia-like manner. Handbook
of Nutraceuticals, Volume 1: Ingredients, Formulations, and
Applications lists information on many ingredients used in
nutraceuticals, developing their formulations and applications. The
book includes contributions from experts with pharmaceutical
backgrounds, providing an examination of nutraceuticals from a
pharmaceutical perspective. Building a foundation with coverage of
historical background, definitions, and challenges, the book offers
insight into nutraceutical ingredients from plant, animal, and
mineral origin. It then covers the characterization of
nutraceuticals' physicochemical, analytical, pharmacological, and
pharmacokinetic classification, followed by information on
regulatory requirements. The book highlights applications in
cardiovascular disease, bone and joint treatments, diabetes
management, weight management, skin health, probiotics and
prebiotics, tranquilizing medicinal plants, dietary foods, and
more. Interest in new diet regimens and new products for increased
health and longevity will continue to grow, giving dietary
supplements an increasing amount of cupboard space in most
households. With quality of content unsurpassed by many resources,
the book discusses the characterization processes for
nutraceuticals based on the contributors' experience in
pharmaceuticals. It then explores how those proven techniques may
be applied to the development and manufacture of nutraceutical
products.
The nutritional and medicinal value of metals, such as zinc,
calcium, and iron, has been known in traditional medicine for a
long time. Other metals, such as silver and gold, may also have
therapeutic and health benefits. Ancient medicines have long
incorporated their use in the treatment of diseases, and they have
also more recently been explored for treatment in allopathic
medicine, birthing the concept of metallonutraceuticals. The
challenge of using metals in the human body is to find forms that
are safe and effective.
Handbook of Metallonutraceuticals presents basic concepts related
to the nutritional and therapeutic use of metals, product
development strategies, and some ideas ready to be applied for
condition-specific metallonutraceuticals. The book begins with an
overview of the nutraceuticals field and the need for
metallonutraceuticals. It considers the roles of various metals in
metabolism, reviews the ethnopharmacology and ethnomedicine of
metals, and covers the characterization and possible properties of
metallonutraceuticals. It also examines bioavailability and drug
interactions, and therapeutic applications of nanometals including
use as imaging agents, in cancer diagnosis and treatment, as
antibacterials and antivirals, in ocular disease, and in
neurodegenerative diseases.
The book explores the use of metals in traditional Chinese
medicine, potential applications for metalloenzymes, the use of
nanosilver in nutraceuticals, and the potential of gold
nanoparticles as a drug delivery system. In addition, it addresses
intellectual property rights and regulatory considerations
regarding metallonutraceuticals. Using an interdisciplinary
approach, this user-friendly text provides a knowledge base and
inspiration for new research in this exciting field.
With the advent of analytical techniques and capabilities to
measure particle sizes in nanometer ranges, there has been
tremendous interest in the use of nanoparticles for more efficient
methods of drug delivery. Nanoparticulate Drug Delivery Systems
addresses the scientific methodologies, formulation, processing,
applications, recent trends, and emerging technologies in the
research of nanoparticulate drug delivery systems (NPDDS). It
extensively covers applications of NPDDS- including lipid
nanoparticles for dermal applications; nanocarriers for the
treatment of restenosis; and for ocular, central nervous system,
and gastrointestinal applications. It also explores its use as an
adjuvant for vaccine development. Supplying insight from
international experts, this guide Discusses formulation for poorly
soluble drugs Presents biological requirements for nanotherapeutic
applications Demonstrates the role of nanobiotechnology in the
development of nanomedicine Documents recent advances in
nanoparticulate technology-including electrospining, formation of
microcrystals, and production of liquid crystalline phases Examines
the technology of metallic nanoparticles
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