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First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void. This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void.This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void. This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
First published in 1996, liposomes have become an important model
in fundamental biomembrane research, including biophysical,
biochemical, and cell biological studies of membranes and cell
function. They are thoroughly studied in several applications, such
as drug delivery systems in medical applications and as controlled
release systems, microencapsulating media, signal carriers, support
matrices, and solubilizers in other applications. While medical
applications have been extensively reviewed in recent literature,
there is a need for easily accessible information on applications
for liposomes beyond pharmacology and medicine. The Handbook of
Nonmedical Applications of Liposomes fills this void.This unique
new handbook series presents recent developments in the use of
liposomes in many scientific disciplines, from studies on the
origin of life, protein function, and vesicle shapes, to
applications in cosmetics, diagnostics, ecology, bioreclamation,
and the food industry. In these volumes many of the top experts
contribute extensive reviews of their work.
Liposomes have become an important model in fundamental biomembrane
research, including biophysical, biochemical, and cell biological
studies of membranes and cell function. They are thoroughly studied
in several applications, such as drug delivery systems in medical
applications and as controlled release systems, microencapsulating
media, signal carriers, support matrices, and solubilizers in other
applications. While medical applications have been extensively
reviewed in recent literature, there is a need for easily
accessible information on applications for liposomes beyond
pharmacology and medicine. The Handbook of Nonmedical Applications
of Liposomes fills this void. This unique new handbook series
presents recent developments in the use of liposomes in many
scientific disciplines, from studies on the origin of life, protein
function, and vesicle shapes, to applications in cosmetics,
diagnostics, ecology, bioreclamation, and the food industry. In
these volumes many of the top experts contribute extensive reviews
of their work.
Remote loading of liposomes by transmembrane gradients is one of
the best approaches for achieving the high drug level per liposome.
This breakthrough, which enabled the clinical use of nanoliposomal
drugs, has not been paralleled by good understanding that allows
predicting loading efficiency of drugs. We developed a model that
relates drug physicochemical properties and loading conditions to
loading efficiency. This model enables choosing candidate molecules
for remote loading and optimizing loading conditions according to
logical considerations. In order to improve the therapeutic
efficacy of two drug combination, vincristine and topotecan were
co- remote loaded by ammonium sulfate gradient in the same
nanoliposome (LipoViTo). The nanoliposomes controlled the drugs'
"biofate" and maintained a fixed drug ratio in vivo.
Pharmacokinetics studies showed that LipoViTo deliver the two drugs
simultaneously to the tumors, where they are released at a
predefined ratio. LipoViTo were more efficacious than the free
drugs and liposomes withone agent, singly or in combination. Our
approach should improve the development of liposomal formulations
for clinical applications.
Liposomes, vesicles with one or more lipid bilayers entrapping an
inner aqueous core, are widely used as drug delivery systems. When
liposomes are smaller than 100 nanometers (nano liposomes) they
have a unique capability of selectively accumulating in tumors and
inflamed tissues. This phenomenon, known as the enhanced
permeability and retention (EPR) effect, is related to the
relatively high 'leakiness' of blood vessels in these diseased
tissues. In this book, we present a novel approach for triggering
drug release from liposomes at the target site, by use of a remote
trigger - low frequency ultrasound. The book includes detailed
descriptions of formulation, characterization, and in vivo
performance of liposome-based drugs, with focus and insights into
the biophysical phenomena governing ultrasound-induced liposomal
drug release. Special attention is given to the principles needed
to formulate ultrasound-responsive liposomes. The book is intended
for people entering the field of liposome-based drug delivery as
well as experienced scientists seeking fundamental understanding of
the mechanism by which ultrasound interacts with lipid bilayers.
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