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1. Prevention and Early Detection of Lung Cancer - Clinical
Aspects.- 2. Smoking Prevention and Cessation.- 3. Clinical
Pharmacology of Vitamin A and Retinoids.- 4. Early Lung Cancer
Detection.- 5. Molecular Abnormalities in the Sequential
Development of Lung Carcinoma.- 6. Application of In Situ PCR and
In Situ Hybridization to the Characterization of Lung Cancers.- 7.
Tumor Stroma Formation in Lung Cancer.- 8. Tumor Angiogenesis:
Basis for New Prognostic Factors and New Anticancer Therapies.- 9.
Cell Cycle Regulators and Mechanisms of Growth Control Evasion in
Lung Cancer.- 10. Molecular Genetics of Lung Cancer.- 11.
Neuropeptides, Signal Transduction and Small Cell Lung Cancer.- 12.
In Vitro Analysis of Bombesin/Gastrin-Releasing Peptide Receptor
(bb2) Ligand Binding and G-Protein Coupling.- 13. DNA Methylation
Changes in Lung Cancer.- 14. K-ras Mutations as Molecular Markers
of Lung Cancer.- 15. Sheep Lung Adenomatosis: A Model of Virally
Induced Lung Cancer.- 16. Retinoic Acid Receptor ss An Exploration
of its Role in Lung Cancer Suppression and its Potential in Cancer
Prevention.- 17. Cytochrome P450 Polymorphisms: Risk Factors for
Lung Cancer?.- 18. Glutathione S-Transferases and Lung Cancer
Risk.- 19. The p53 Tumor Suppressor Gene in Lung Cancer: From
Molecular to Serological Diagnosis.- 20. Endoscopic Localization of
Preneoplastic Lung Lesions.- 21. Antigen Retrieval Improves hnRNP
A2/B1 Immunohisto-chemical Localization in Premalignant Lesions of
the Lung.- 22. Molecular Pathological Mechanisms in NSCLC and the
Assessment of Individuals with a High Risk of Developing Lung
Cancer.- 23. Chemoprevention of Lung Cancer.- 24. Regional Delivery
of Retinoids: A New Approach to Early Lung Cancer Intervention.-
25. Natural Inhibitors of Carcinogenesis.- 26. Gene Delivery to
Airways.- 27. Lung Cancer Prevention: The Point of View of a Public
Health Epidemiologist.- 28. Biomarkers as Intermediate Endpoints in
Chemoprevention Trials: Biological Basis of Lung Cancer
Prevention.- 29. Biological Tools for Mass Screening.- 30.
Optimization of the Use of Biological Samples for the Prospective
Evaluation of Preneoplastic Lesions.
Lung cancer is a disease with pandemic public health implications
as it is now the leading cause of cancer mortality throughout the
world. This book results from two recent International Association
for the Study of Lung Cancer (IASLC) Workshops on lung cancer
prevention. It strikes a balance between considering public health
approaches to tobacco control and population-based screening,
advances in clinical evaluation of chemoprevention approaches, and
the biology of lung carcinogenesis. Indeed, while the science of
smoking cessation is evolving as new pharmacological tools are
moving into clinical evaluation, the current impact of molecular
diagnostics is profound. The rapidly-evolving diagnostic
technologies are revolutionizing basic scientific investigation of
cancer, and this trend is expected to soon spill over into the
clinical practice of medicine. The evolution of economical
diagnostic platforms to allow for direct bronchial epithelial
evaluation in high-risk populations promises to improve the
diagnostic lead-time for this disease. The hope is that enough
progress will occur to permit lung cancer detection in advance of
clinical cancer so that the disease can be addressed early on,
while it is still confined to the site of origin. Chemoprevention,
which is designed to intervene in the early phase of carcinogenesis
prior to any subjective clinical manifestation of a cancer, is also
generating greater research interest. Moreover, the benefit of
aerosolized administration of chemoprevention agents over
conventional oral administration has strong appeal and may result
in the reduction of the incidence of cancer when combined with new
diagnostic technologies.
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