This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

A significant improvement in the safety of modern vaccines has been the development of subunit vaccines, as these are composed of very well-defined and highly pure components, often recombinant proteins. However, since protein-based antigens in general are weakly immunogenic by themselves, co-administration of adjuvants is required to induce potent and persistent specific immune responses. In recent years, there has been substantial progress in the discovery of new efficient adjuvants for subunit vaccines that are often classified into delivery systems and immunopotentiating compounds that constitute pathogen-associated molecular patterns, such as the toll-like receptor ligands. The combination of delivery systems and immunopotentiators has appeared to represent extraordinarily good adjuvants due to concomitant enhanced antigen delivery and potent stimulation of innate immunity. Many of these adjuvants are of a particulate nature and mimic the structure and/or composition of microbes in a reductionist fashion. Examples are liposomes, polymeric nanoparticles, emulsions and virus-like particles. However, there are a substantial number of pharmaceutical challenges associated with the subunit vaccine development process due to the complex nature of the antigen-adjuvant combinations. These challenges will be presented and discussed in this book. The objective of the book is to compile the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. The books goal is to provide a comprehensive overview of the scientific and regulatory challenges facing scientists who research and develop subunit vaccines. The scope of the book is wide. It is written in a manner that will enlighten newcomers to the field (e.g., PhD students or experienced scientist switching fields) yet provide an in-depth knowledge that would benefit a skilled worker in the field. "

If you are a HR/line manager or seeking flexible working and wanting guidance on what to expect, this book is for you. The book covers: descriptions and suitability of the main types of flexible working; the legal implications; the procedure for requests,consideration and responses and permitted reasons for refusal; and, advice on adopting a flexible working policy and putting it into practice. In the Speed Read series: this book is affordable and concise. It includes top tips, real life examples from voluntary organisations, checklists to help decide on a suitable policy and clear pointers to other sources of information.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration-in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

This "FASTtrack" book systematically reviews important concepts and facts relating to the delivery and targeting of drugs. Relevant examples of delivery systems are given throughout the book with a focus on delivery systems that have actually reached clinical reality.

You may be one of the millions of people who are spiritually growing faster than your body can tolerate. What you are experiencing is a normal response known as ascension symptoms. Learn how to manage these symptoms and anchor your light body while you help the Earth and others ascend. Shifting into Purer Consciousness is astonishing in its breadth and depth of knowledge in what it means to be a spirit being in human form at this particular time. A truthful and candid a discussion of the human condition and ascension consciousness. Within these pages, you will discover that vital guidance to help you on your ascension path.

a collection of poetry about dreams

ARE YOU EMPATHIC? Are your coworkers, friends, and family members like psychic vampires who siphon your energy and leave you feeling drained? Feeling angry, depressed, or sick most of the time? You may be an empath picking up on the detrimental thoughts, emotions, and attitudes of others. Whose Stuff Is This? Finding Freedom from the Thoughts, Feelings, and Energy of Those Around You is for those who carry energetic burdens that belong to someone else. More than two dozen proven and effective ways to clear your energy field, this guide employs empowering, proactive techniques to manage your own energy. With a chapter on the psychology of empathy by Dr. Caron Goode, this book presents the personal story of how the author learned to psychically protect herself. Shield yourself from unwanted energy as you develop emotional intelligence Offer compassion without paying a personal price Set boundaries and detach from environmental stimuli including the energy of people and entities Raise your vibration to a level that makes you invisible to lower-vibrating energy A brilliant, much-needed guidebook for children and adults whose gift of empathy can also be their greatest challenge . . . excellent techniques to use this gift of emotional connection in alignment with one's soul's purpose. Devra Ann Jacobs, President, Dancing Word Group LLC A comprehensive book for anyone interested in developing their intuition and psychic abilities. Presented in an easy-to-read manner, Yvonne has created an encyclopedia of knowledge pertaining to the healing arts. Harriette Knight, author of CHAKRA POWER How to Fire Up Your Energy Centers to Live a Fuller Life This book should be required reading for all human beings as we continue to learn how to navigate our energy bodies while being in a physical body. With thorough research and case examples, the information on setting boundaries is a must-read whether you consider yourself to be an empath or not. Tisha Morris, author of 27 Things to Feng Shui Your Home . . . an extensive library of answers that can help you figure out what's going on while also empowering you to do something about it Elise Lebeau, M.Sc., Professional Intuitive, Founder of the EmpathCommunity.EliseLebeau.com

Frankie the Walk 'N Roll Dog keeps rolling along in her doggie wheelchair. This paralyzed dachshund's unabashed healing, exuberant spirit, and spunky personality is a blessed gift to everyone she befriends. In this true, inspirational story, Frankie tells how she became a registered therapy dog and shares her visits to Libby's House, a senior facility where many residents have Alzheimer's or dementia. Frankie teaches us that patience, listening, and understanding opens our hearts to what matters most-love. With this lovely book, Frankie will win your heart and inspire children to overcome whatever obstacles they face in life. Told from Frankie's viewpoint, this journey from using a wheelchair (dog cart) to finding her purpose as a therapy dog is not only touching but also shows children how much joy, healing, and hope a dog can bring to this world. Outstanding! ~Linda and Allen Anderson, authors of Angel Animals books www.angelanimals.net

More Than Meets the Eye shares true stories and sheds light on euthanasia, suicide, near-death experience, hospice care and much more. Spirit visits by a deceased loved one are very common and show how we are still connected even after we leave the body behind. You'll find comfort and peace about the mysterious process of transitioning back to God/Source in this delightful exploration into the unknown by an author who openly shares her soul. A welcome blend of intrigue, courage and adventure, that will open your mind, calm your spirit, alleviate your fear of death and lighten your heart.

Ensuring competency in maths skills is a fundamental part of pharmacy education as accurate pharmaceutical calculations are crucial to the safe and effective use of drugs. This text combines both the scientific calculations underpinning dosage forms with calculations relating to pharmacy practice in a single resource. An innovative student-centred approach is taken throughout the text, with numerous worked examples and self-test questions to stimulate self-directed learning. Frequent case studies highlight the importance of maths to pharmacy, and help students to make that crucial connection between theory and practice, while key take-home messages for each section are summarised in concise learning-point boxes. Written by leading academics with a wealth of experience in pharmacy education Maths Skills for Pharmacy is the ideal textbook for the subject. Online Resource Centre The Online Resource Centre to accompany Maths Skills for Pharmacy features: For registered adopters of the book: - Figures from the book, available to download. For students:-Interactive multiple choice questions with feedback keyed to the relevant section in the text -Short answer questions with worked solutions

This guide is for those who know that the ostrich attitude leaves talent untapped and that to be on the wrong side of the law is expensive in time, money, relationships and reputation. The book includes: the essentials of unlawful age discrimination as in the 2006 Regulations; advice on what to include in policy on age discrimination; how to avoid age discrimination complaints; and, guidance on how to turn policy into practice throughout your organization. In the Speed Read series: this book is handy, affordable and concise. It includes top tips, case studies and clear signposts to other sources of information.