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A simple spectrophotometric method for determination of cefaclor in
raw and dosage forms based on reaction with ninhydrin is developed,
optimized and validated. The purple color (Ruhemenn's purple)
resulted from the reaction was stabilized and measured at 560
nm.The method optimization was essential as many procedural
parameters influenced the accuracy of determination all variables
including the reagent concentration, heating time, reaction
temperature, color stability period, and cefaclor/ninhydrin ratio
were studied in order to optimize the reaction conditions. No
interference was observed from common pharmaceutical adjuvant. The
developed method is easy to use, accurate and highly cost-effective
for routine studies relative to HPLC and other techniques.
An extensive literature assessment is done and it is obvious that
the methods are accessible for Ranitidine. HPLC is very expensive
instrument and are not available in every laboratory. While
UV/Visible spectrophotometer is a common instrument of all
pharmaceutical analytical laboratory. Spectrophotometric analysis
methods available for Ranitidine are tedious, time consuming and
not much sensitive in term of precision and accuracy. It becomes
essential to develop new rapid and cost effective methods that
spectrophotometric determination would be simple, accurate, precise
and sensitive. The newly developed analytical methods can be used
in research institutions, Quality control in pharmaceutical
industries, Approved testing laboratories and Bioequivalence
studies.
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Higher
Michael Buble
CD
(1)
R172
R154
Discovery Miles 1 540
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