Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.

Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.

This two-volume set LNCS 12131 and LNCS 12132 constitutes the refereed proceedings of the 17th International Conference on Image Analysis and Recognition, ICIAR 2020, held in Povoa de Varzim, Portugal, in June 2020. The 54 full papers presented together with 15 short papers were carefully reviewed and selected from 123 submissions. The papers are organized in the following topical sections: image processing and analysis; video analysis; computer vision; 3D computer vision; machine learning; medical image and analysis; analysis of histopathology images; diagnosis and screening of ophthalmic diseases; and grand challenge on automatic lung cancer patient management. Due to the corona pandemic, ICIAR 2020 was held virtually only.

This two-volume set LNCS 12131 and LNCS 12132 constitutes the refereed proceedings of the 17th International Conference on Image Analysis and Recognition, ICIAR 2020, held in Povoa de Varzim, Portugal, in June 2020. The 54 full papers presented together with 15 short papers were carefully reviewed and selected from 123 submissions. The papers are organized in the following topical sections: image processing and analysis; video analysis; computer vision; 3D computer vision; machine learning; medical image and analysis; analysis of histopathology images; diagnosis and screening of ophthalmic diseases; and grand challenge on automatic lung cancer patient management. Due to the corona pandemic, ICIAR 2020 was held virtually only.

I have just three things to teach: simplicity, patience, compassion. These three are your greatest treasures.Lao Tzu Funny, but the Master of wealth-building says the same thing: "The stock market is a device for transferring money from the impatient to the patient." Warren Buffett Patience is important in life and in building wealth. Most investors are not patient so most investors are not wealthy. In fact, the average investor earns only 2.56% annually according to DALBAR's annual Qualitative Analysis of Investor Behavior. Mr Buffett's strategy of patience is the most successful. He earns about 20% a year compounded over time. He does not buy and sell stock. In other words, he holds the stock of companies for a long time. Most investors jump from one successful stock or mutual fund to another. Each time they do this, they are basically paying at the higher price AFTER the security has proved successful. Each time they are disappointed and then sell at a lower price. Every buy and sell transaction costs them a commission or fee, reducing their gains even more. They earn 2.56% while Buffett earns 19.7%. Wu wei is the core of the Wealth Tao. It means there is no need to struggle to reach our goals. Once we establish our stock portfolio or mutual funds, we do nothing to stop the growth of our account. We patiently let the market provide our wealth. Buffett has been patient for over 40 years and has grown his initial investment of $6,000 (from paper routes) to $65 billion. You don't need to do a thing to grow your money in the stock market. As Buffett has said: We continue to make more money when snoring than when active. berkshirehathaway.com/letters/1996

Prostate cancer (PCa) is a disease with high incidence and prevalence. Early detection of PCa has been an area for research to decrease its morbidity and mortality. The discovery of prostate specific antigen (PSA) revolutionised screening of PCa, which was largely dependent on detection of prostatic acid phosphatase and digital rectal examination. Several leading organisations and cancer societies, based on present evidence, have published their recommendations for its use in detection and monitoring of PCa. There has been difference in opinions on its appropriate threshold value to recommend prostate biopsy and benefits on health outcomes due to its use in screening. This book presents and discusses current research in the study of PCa and it's role in the screening of prostate cancer.