This collection of original essays by economists, biologists and political scientists has a common theme: that protecting species at risk while safeguarding social order is a policy challenge that entangles biology, politics, and economics. Nearly 1200 species are listed as endangered or threatened under the Endangered Species Act (ESA) of 1973; only twelve have been removed from the list. Attempts at species recovery on public and private property lead the authors to examine the political realities that define the debate: who should pay the costs and receive the benefits, and how interest group behaviour affects the nature of endangered species protection. Although the ESA directs administrative agencies to list and protect species following scientific priorities, the collection addresses the economic choices that still must be confronted. These range from the protection potential of private markets to the design of incentive schemes to encourage conservation by private landowners.

Estimates of the air pollution health impact play a crucial role in environmental protection. These estimates require accurate data on the pollutant exposure and dose to the population as well as the dose-response relationships to calculate the health impact. From an air quality manager's perspective there is concern about the validity and accuracy of these calculations. There is a need for information and possible ways to adjust the assessment. One important topic for air quality managers is to understand the relative cont- bution of sources to the total exposure. These sources may be coming from both different outdoor sources from sectors such as transport, industry and energy ind- tries, and from a number of indoor sources, such as heating, ventilation and indoor activities as well as out-gassing from building material and furniture. Indoor air quality is now drawing the attention of policy makers. The basic right to, and importance of, healthy indoor air was emphasized by the World Health Organization as early as 2000 and several countries have described target conc- trations for various pollutants. The WHO Air Quality Guidelines 2005 rec- mended the development of specific guidelines for indoor air quality and these are expected to be published soon. Indoor air pollutants have not been as extensively monitored as outdoor air pollutants and the evidence base for contributions to health effects needs to be strengthened.

Seasonal patterns have been found in a remarkable range of health conditions, including birth defects, respiratory infections and cardiovascular disease. Accurately estimating the size and timing of seasonal peaks in disease incidence is an aid to understanding the causes and possibly to developing interventions. With global warming increasing the intensity of seasonal weather patterns around the world, a review of the methods for estimating seasonal effects on health is timely.

This is the first book on statistical methods for seasonal data written for a health audience. It describes methods for a range of outcomes (including continuous, count and binomial data) and demonstrates appropriate techniques for summarising and modelling these data. It has a practical focus and uses interesting examples to motivate and illustrate the methods. The statistical procedures and example data sets are available in an R package called season ."

This book examines the policy and politics of two health risks, which have recently become prominent social issues in many countries. One is the issue of asbestos as an environmental risk to humans, and another is that of bovine spongiform encephalitis (BSE), or mad cow disease as an animal disease, and of its variant Creutzfeldt-Jakob disease (CJD) as a human food risk. Employing a set of analytical frameworks in political science, each case study explores how the issues emerged, agendas got set, alternatives were chosen, and policies were implemented. Through the analysis, it is examined how safety and public reassurance were pursued in the countries studied (Japan, the UK, France the USA, and Korea). Exploration of the successes and failures in their efforts discloses the key elements to successful health risk management.

This highly practical guide is ideal for any medical professional who deals with the aerospace environment or is involved in the healthcare of aircrew or individuals preparing for or returning from aerospace travel. The book covers all the main aspects of aerospace medicine, including the salient physiology and clinical aspects in note form for rapid assimilation, and makes plentiful use of figures, algorithms and tables throughout. Key Features: * Comprehensive covering all aspects of clinical aerospace medicine and relevant physiology * Note-based for rapid reference in the clinical setting * Highly practical with illustrations and tables supporting the text throughout * From a highly experienced international team of editors and contributors * Ideal as a handbook companion, complementing the definitive reference Ernsting's Aviation and Space Medicine, for use 'on the go' The book will be an indispensable companion to all civil and military aviation medicine practitioners including those preparing for professional qualifying examinations, and a useful aid for other physicians with an interest in aviation medicine or who are required to inform patients regularly regarding the likely effects of flight, including family practitioners and hospital doctors, physiologists with an interest in the area and occupational and public health personnel.

The second edition of a bestseller, Soil and Water Chemistry: An Integrative Approach maintains the balanced perspective that made the first edition a hugely popular textbook. The second edition includes new figures and tables, new chapters, and expanded exercises in each chapter. It covers topics including soil chemical environment, soil minerals, soil organic matter, cation exchange, oxidation-reduction, mineral weathering and solubility, surface chemistry and adsorption reactions, acidity and salinity in soil materials, and chemical thermodynamics applied to soil systems. See What's New in the Second Edition: Extensive section that details the sources, speciation, and the general behavior of elements in soils Expanded section on crystal structure, updated phyllosillcates classifications scheme, inclusion of sepiolite-palygorskite group, and expanded x-ray diffraction section Discussion of surface runoff losses of phosphorus from soil and description of the inductivity coupled argon plasma-mass spectroscopy (ICP-MS) analytical technique for determining elemental concentrations in soil solution Coverage of the influence of redox processes on the soil chemistry of nonelectroactive elements Description of the electrokinetic phenomenon and investigation of the influence of temperature on adsorption Expanded discussion on the application of chemical thermodynamics to soil systems A solutions manual is available upon qualifying course adoption. Still one of the only texts on this subject, this book provides a comprehensive, modern, and balanced coverage of the chemical and mineralogical characteristics of soils and their chemical processes. It contains more information and topic coverage than required for an average, single-semester course. This extensive coverage is by design, giving you the latitude to pick your own essential topics while providing additional information or a more advanced treatment when needed. Figures and tables make the information accessible and each problem has been tested and is relevant and doable, but asks more of students than to simply generate a number. This format allows students to understand the concepts and recognize that their computations have physical meaning.

Air Pollution and Human Cancer analyzes the evidence for the possible contribution of air pollution to the origin of human cancer. Distinguished experts in various areas of cancer research report on: - air pollution and cancer: an old and a new problem; - sources, nature and levels of air pollutants; - measurement and monitoring of individual exposures; - experimental evidence for the carcinogenicity of air pollutants; - epidemiological evidence on air pollution and cancer; - cancer risk estimation and prevention.

This highly topical book provides an in-depth account of the South Asian experience with the deadly disease that has held this region hostage for millennia. The book touches specifically on the resurgence of malaria experienced in the second half of the twentieth century, which occurred just a few years after malaria was thought to have been virtually eradicated from the region. The progress of this reappearance across space and time, as well as its causes and consequences, are discussed. The book also covers past, present and future ways to curb, control and ultimately, conquer malaria. As malaria continues to ravage the developing world, even in today s age of science, this is a particularly relevant book, especially as most studies analyze the problem in Africa, the continent that bears the brunt of this disease. Here, the authors call attention to challenges in South Asia, home to an immense at-risk population. The chapters in this book use a range of conceptual frameworks, quantitative analyses and descriptive aapproaches, finding that malaria is not just a complex disease driven by highly adaptive agents and vectors thriving in particular ecologies, but also a social concern deeply related to the region s cultural traditions, financial and developmental shortfalls, and inexorably related to political will.

The book comprehensively deals with all aspects of the malaria situation in South Asia, and is invaluable to upper level students as well as emerging and established scholars in the fields of medical geography and epidemiology, Asian studies and development studies."

Almost 50 million persons visit another continent each year. It is mainly those 15-18 million travelers from industrialized nations who visit or reside in developing countries that are at increased health risk. To develop effective health protection advice, the health risks of travel and the benefits of prophylaxis (vaccines, new and old drugs, behaviour modification, etc.) should be assessed systematically. The purpose of this book is to improve the protection of the travelers' health by more effective and more uniform recommendations. It contains many data on recent research and represents the first comprehensive account on travel medicine for professionals.

The syllabus for the FRCS (ORL-HNS) is vast, and sound preparation for the exams has traditionally involved assimilating knowledge from a wide range of sources. This book provides a focused guide for exam candidates. More than a question and answer book, this book is a coaching manual. Each section features a combination of model answers, pearls of wisdom, checklists and pointers for further reading. Detailed advice is provided for both Part 1 and Part 2 of the examination. Viva topics that have featured in the exam in recent years have been included. and are supplemented by invaluable editorial contributions from leaders in each of the subspecialties. Trainees frequently comment that exam preparation is an enlightening process and the knowledge gained would have served them well during their time as an ENT registrar or Otorhinolaryngology resident.This book will also serve as a valuable learning tool for trainees as early as ST3 and will facilitate the development of effective and safe clinical practice.

The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . xiii . . . . . . . . . . . . . Part I. Integrative Approach to Assessing Human Health Risk: Two Contemporary Problems Chapter 1. Integrating Diverse Data Sets to Assess the Risks of Airborne Pollutants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 R.o. McClellan, R.G. Cuddihy, w.e. Griffith, and J. L. Mauderly Chapter 2. Risk Assessment for Radon Inhalation Based on Animal Exposure Data and Human Epidemiology . . . . . . . 23 . F. Steinhausler Part II. Types of Evidence: General Strengths and Weaknesses Section 1. Epidemiological Chapter 3. Inhalation Hazards: The Interpretation of Epidemiologic Evidence. . . . . . . . . . . . . . . . . . . . 39 . . . . . . . J.e. Bailar Chapter 4. Problems in Interpreting Epidemiological Data 49 P.N. Lee Section 2. Animal Chapter 5. Rodent Carcinogenicity Studies: Their Value and Limitations. . . . . . . . . . . . . . . . . . . . . . . . . . 61 . . . . . . . . . .

In a new era of global health diplomacy, the most important tool for decision-making is negotiation. Globalization is binding countries, issues and people together as never before. In the domain of public health, traditional international concerns like the spread of infectious diseases have been joined by new concerns and challenges in managing the health impacts of trade and intellectual property rights, and by new opportunities to create effective global public health agreements and programs. To address the major health crises of today and to prevent or mitigate them in the future, countries must seek collective agreement and action within and across their borders. However, the world of international negotiation is not the world in which health decision-makers reside or are most comfortable. The goal of this guide is to provide health policy-makers with practical information and negotiation tools, to help them create better international health agreements and programs. "This is the best book I know to help health professionals develop the negotiation skills necessary to meet the challenges of global health diplomacy. It is filled with wise advice and invaluable tools for success." Professor Jeswald W. Salacuse, The Fletcher School of Law and Diplomacy, Tufts University

As part of its "Programme for the prevention of health hazards caused by industrial substances", the Berufsge- nossenschaft der chemischen Industrie (BG Chemie, Em- ployment Accident Insurance Fund of the Chemical Indus- try) began in 1977 to investigate the toxicity of those chemicals which are widely used, have many different ap- plications and are suspected of being dangerous to health, in particular of having long-term effects. The in- vestigations consist of a literature search and - depending on the results - commissions of experimental studies. It is hoped by means of this testing to close gaps in our know- ledge and to increase the scientific validity of the required risk assessments. The results of the toxicological in- vestigations carried out by BG Chemie, and the resulting substance assessments have been published in German since 1987 in the form of 113 "Toxikologische Bewer- tungen" ("Toxicological Evaluations") up to now. In order to make this useful information internation- ally available, BG Chemie began in October 1990 to pub- lish them as a book series in English, of which the fifth vol- ume (containing 12 individual evaluations) is presented here. Therefore for 72 existing chemicals "Toxicological Evaluations" are available in English at the moment, a fur- ther 38 are in preparation and will be published soon.

"Toxicological Evaluations" are critically assessed data and recommendationsfor occupational safety officers, industrial hygienists, and human and animal toxicologists. They are compiled and constantly reviewed under internationally coordinated programms for establishing the risk potential of existing chemicals to prevent health hazards at the working place. Data for the following 61 chemicals have been published in the series: Acrylic acid, Benzalchloride, Benzotrichloride, Benzoylchloride, Benzylchloride, Bromoform, Butynediol, gamma-Butyrolactone, 4-Chloro-2-nitroaniline, Chloro acetic acid methyl ester, Chloroacetamide, o-Chlorobenzotrichloride, p-Chlorobenzotrichloride, o-Chlorobenzotrifluoride, m-Chlorobenzotrifluoride, Chloroformic acid ethyl ester, 4-Chlorophenyl isocyanate, m-Cresidine, N, N'-Di-sec.-butyl-p-phenylenediamine, 1,4-Diaminoanthraquinone, 1,4-Dicyanobutane, Dicyclopentadiene, Diethanolamine, Diethylcarbamoyl chloride, Diethyliene glycol, Diglycidyl ether, Diisopropanolamine, Dimethyl therephthalate, 2,4-Dinitromethylaniline, Ethylene thiourea, 2-Ethylhexanal, 2-Ethylhexanol, Hydrazobenzene, Isopropyl ethylene glycol ether, Maleic acid dimethyl ester, Manganese dioxide, 2-Mercaptobenzothiazole, Methoxyacetic acid, Methylbutadiene -1,3, 3-Methylbutanol-1, 2-Methylpropanol-1, 2-Methylpropene, Monochloroacetic acid, 1,5-Naphthalene diamine, 5-Nitro-2-aminotoluene, m-Nitroaniline, 5-Nitroanisidine, p-Nitrosophenol, Phenyl isocyanate, Phenylglycidyl ether, o-Phthalodinitrile, Propargyl alcohol Sodium hypochlorite, Therephthalic acid, Thiram, Tributyl phosphate, Triethanolamine, Triethylene tetramine, Trimethylphenyl-ammonium chloride, Trimethylquinone, Vinyl fluoride.

This series is dedicated to serving the growing community of scholars and practitioners concerned with the principles and applications of environmental management. Each volume is a thorough treatment of a specific topic of importance for proper management practices. A fundamental objective of these books is to help the reader discern and implement man's stewardship of our environment and the world's renewable resources. For we must strive to understand the relation ship between man and nature, act to bring harmony to it, and nurture an environment that is both stable and productive. These objectives have often eluded us because the pursuit of other individual and societal goals has diverted us from a course of living in balance with the environment. At times, therefore, the environmental manager may have to exert restrictive control, which is usually best applied to man, not nature. Attempts to alter or harness nature have often failed or backfired, as exemplified by the results of imprudent use of herbicides, fertilizers, water, and other agents. Each book in this series will shed light on the fundamental and applied aspects of environmental management. It is hoped that each will help solve a practical and serious environmental problem."

As part of its programme for the prevention of health hazards caused by industrial work substances, the Berufsgenossenschaft der chemischen Industrie (BG Chemie) began in 1977 to investigate the toxicity of those substances which are widely used, have many different applications and are suspected of being dangerous to health, in particular of having long-term effects on health. It is hoped by means of this testing to close gaps in our knowledge and to increase the scientific validity of the required risk assessments. The results of the toxicological investigations carried out by BG Chemie, and the resulting substance assessments have been published in West Ger many since 1987 in the form of "Toxicological Evaluations". In order to make this useful information internationally available, the second volume (containing individual evalua tions of 15 substances) is now being published in English. The first volume containing individual evaluations of 19 substances was published in October 1990. Because of the short time between publishing volumes 1 and 2, printing of the "Introduction" (consisting of a general overview of the programme, lists with names of people involved as well as substances under investigation was abandoned in volume 2. If there more detailed information is required, see volume 1 or contact BG Chemie at first hand. The publication of further individual evaluations and, if necessary, reassess ments of previously published evaluations is planned.

Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program.

As part of its "Programme for the prevention of health haz- ards caused by industrial substances", the Berufsgenossen- schaft der chemischen Industrie (BG Chemie, Employment Accident Insurance Fund of the Chemical Industry) began in 1977 to investigate the toxicity of those chemicals which are widely used, have many different applications and are suspected of being dangerous to health, in particular of hav- ing long-term effects. The investigations consist of a litera- ture search and - depending on the results - commissions of experimental studies. It is hoped by means of this testing to close gaps in our knowledge and to increase the scientif- ic validity of the required risk assessments. The results of the toxicological investigations carried out by BG Chemie, and the resulting substance assessments have been published in German since 1987 in the form of 169 "Toxikologische Bewertungen" ("Toxicological Evaluations") up to now. In order to make this useful information internationally available, BG Chemie began in October 1990 to publish as a book series in English, of which the eighth volu- them me (containing 14 individual evaluations) is presented here. Therefore for 110 existing chemicals "Toxicological Evalua- tions" are available in English at the moment, a further 54 are in preparation and will be published soon.

Die Naturwissenschaften; Edward Arnold Co.; Research in Veterinary Science; Ltd.; Farm Mechanization and Buildings; Springer Verlag; The Ciba Foundation Ltd.; Journal of Agricultural Science; Journal of The Institute of Biology; The Lancet; The Reproduction and Fertility; Lea and Febiger; Physiological Society (G. B.); The Royal Masson et Cie, Paris; MacMillan Publishing Society; University of Chicago Press; Uni- Co., Inc.; National Academy of Science, versity of Rhodesia; Verhandlungen der U.S.; National Research Council of Canada; Deutschen Gesellschaft fur KreislautJorsch- Nature, London; North Holland Publishing ung; Waverly Press; and W. B. Saunders. Co.; Oxford University Press; Pergamon Press; Physiology and Behavior; Poultry D. L. INGRAM Science Association; Reinhold Publishing L. E. MOUNT Contents Preface Chapter 1 The Thermal Eml'ironment 1 Hot, Thermally Neutral, and Cold Environments 1 Development of Climatic Physiology 3 Physical Principles Chapter 2 Heat Exchange between Animal and Environment 5 Metabolic Heat and Its Dissipation 5 Body Temperature 6 Poikilotherm and Homeotherm 7 Heat Flow 8 Sensible Heat Transfer 9 Evaporative Heat Transfer 16 Calorimetry 21 Chapter 3 Metabolic Rate, Thermal Insolation, and the Assessment of Environment 24 Metabolic Rate and Heat Loss at High Temperatures 24 Thermal Conductance and Insulation 27 Evaporative Heat Loss 31 The Assessment of Thermal Environment 34 Responses of Different Species to High Temperatures 37 Physiological Mechanisms Chapter 4 Evaporative Heat Loss 39 Evaporative Loss from the Respiratory Tract 39 ix x Contents Conservation of Water Loss from the Respiratory 40 Tract in a Hot Dry Climate

More than 10 years ago, I had the chance to visit the university hospital in Munster, Germany. At the outpatient clinic there, I accidently met a young dermatologist who was devoted to the study of the quantification of irritated skin during his busy daily clinical work. I sensed immediately that this Dr. P. Frosch was conducting his research with the ideals and enthusiasm which were so familiar to me. Soon we found that we shared a similar past experience; we both had begun our careers in dermatological investigation with the same mentor. For me it was more than 25 years ago that I first met Dr. Kligman, Professor at the University of Pennsylvania in Philadelphia, USA. I reminisced that I had been greatly shocked by his initial question ''As a dermatologist, do you want to study living or dead skin?" because, at that time and even today, whenever we cannot collect enough information about the skin with the naked eye, it is invasively removed is common practice to histologically examine a skin sample that from living tissue. Many dermatologists still would never think of studying the living intact skin itself noninvasively with the aid of existing advanced technologies to assess its structural and functional properties. At that time Dr. Kligman intended to build up a system of evaluating the skin from various aspects, using methods that had been unduly neglected in the past and introducing various technological instruments.

ENVIRONMENTAL HYGIENE III deals with the detection and evaluation of environmental pollutants as well as with their relevance to human health. Environmental components are important determinants of the health status of groups at risk and of the general population. The main objective is the early detection and identification of hazardous substances by physical, chemical and biological methods, risk assessment andprotection of human health. Faced with these problems the volume gives an overview on the mulifaceted aspects of environmental hygiene and medicine. Contributions include basic and innovative approaches in the fields of - Experimental cell biology - Cytotoxicity testing - Mutagenicity and carcinogenicity studies - Inhalation toxicity - Human exposure monitoring - Epidemiology - Important harzardous agents - Environmental control, prevention and legislation.

The Third International \ orkshop on "The in Vitro Effects of Mineral Dusts" was held on October 1 - 4, 1984 in Schluchsee, Black Forest, Federal Republic of Germany. In six sessions, 93 participants from 14 countries (USA 32, France 17, United Kingdom 12, FRG 11, Canada 9, Belgium 3, Hungary 1, Italy 2, India 1, Nether lands 1, Norway 1, Poland 1, Portugal 1, Turkey 1) treated and discussed the following subjects: - Significance of the physico-chemical properties of inhalable mineral dusts (mine dusts, asbestos, Man-Made Mineral Fibres - MMMF). - Cellular effects of inhalable mineral dusts with special regard to target ce 11 s. - Immune response and immune toxicity. - Carcinogenicity and interrelated genotoxic and non-genotoxic effects. - Effect of cell metabolism in combination with inflammation and fibrogenesis. - Significance and credibility of in vitro test systems. For the pathogenesis of biological effects and diseases caused by inhalable mineral dusts a number of factors may be significant such as: - Type of dust - Dose of dust - Size and shape of dust particles, and especially - Surface properties of dust particles, which inter alia determine the - sorption properties, e.g. for environmental substances."

The identification of occupational cancer risk factors and of carcinogens in the workplace is assuming increasing import ance in cancer epidemiology. This book, which contains the proceedings of a symposium held in Vancouver in June 1988, combines overviews by experts on substantive topics and methodologic issues of broad interest in occupational cancer epidemiology. Among the former are state of the art reviews emphasizing recent data and new and innovative analytic approaches. The substantive topics include discussion of cancer risks from exposure to complex organic mixtures, asbestos and man-made fibers, herbicides, radon, and electromagnetic fields. Risk assessment, exposure assessment, and analysis of occupa tional cohort studies are examples of the methodologic issues addressed. This book provides basic information and opens perspectives on new areas of research. In organizing our symposium we were greatly assisted by Betty Fata and Kim Rust of Venue West Conference Ltd. We appreciate the financial support received from the following: Cancer Control Agency of British Columbia Alcan Aluminium Ltd. National Health Research & Development Program Workers' Compensation Board of British Columbia Purdue Frederick Inc. Rhone-Poulenc Pharma Inc. London Drugs Ltd. Ciba-Geigy Canada Ltd. Bristol-Myers Pharmaceutical Group Schering Canada Inc. Hoffmann-La Roche Ltd. Sterling Drug Ltd. Parke-Davis Canada Inc. Beecham Laboratories Pfizer Canada Inc. Roussel Canada Inc."

M. Pliftski Institute of Oceanography, GdaJisk University 46 Pilsudskiego Av. 81-378 Gdynia, Poland 2 The Baltic Sea with 366,000 km is only 0. 1% of the world's oceans but nevertheless, unique in many ways. The Baltic Sea is the largest area of brackish water in the world. As a formation of nature, it is a sea that in many ways resembles a lake. This makes its flora and fauna interesting and well adapted to the brackish water environment. The recent stage of biocoenosis composition is influenced by several features. Historically, during the last glaciation, when the Baltic was sometimes a huge marine bay and sometimes a large, freshwater lake, several ecosystems developed and were successively replaced. The flora and fauna composition of those previous biocoenosis was discovered from the geological layers corresponding to the Yoldic Sea, the Ancylus Lake and the Littorina Sea periods. Recently the marine influence has come from the North Sea water inflow, which greatly affects the salinity of the deep water. The freshwater influence comes from the fluvial water which gives the surface layer a lower salinity value. Salinity in the Baltic regions varies greatly - Gulf of Bothnia 2-4%0, the central Baltic proper 7-13%0, the Kattegat 15-300/00 in the surface water and 32- 34%0 in the bottom water, the Skagerrak 20-300/00 in the surface and 32-35%0 in the bottom water.