Written by experienced expeditioners, the handbook is organized in to eight main sections and includes information on fieldcraft, diagnosis and treatment of medical problems encountered during an expedition (divided anatomically), environmental hazards, crisis management and issues to be dealt with after returning home. It also covers basic information about how to plan for an expedition, how to keep the expedition members healthy, how to diagnose and manage their medical problems in remote environments and provide brief summaries of medical problems peculiar to different expedition environments.
This pocket-sized book contains all you need to know to minimise health risks, to protect your health and to deal with unexpected medical problems while you are travelling in remote, wilderness areas of the world.

As yet, flow cytometry is not used so widely in microbiology as in some other disciplines. This volume presents contributions flow cytometry to study a from research microbiologists who use diverse set of problems. It illustrates the power of the technique, and may persuade others of its usefulness. Most of the con tributors gathered in Cardiff on 23 October 1991, at a meeting organized for the Royal Microscopical Society by Dr. Richard Allman, but the content of their chapters is not limited by the discourse of that meeting, and for balance other experts were invited to write for this book. Flow Cytometry in Microbiology thus represents the first collection of articles specifically devoted to the applications of a technique which promises so much to those investigating the microbial world. Cardiff, 1992 David Lloyd Contents List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Flow Cytometry: A Technique Waiting for Microbiologists David Lloyd . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 The Physical and Biological Basis for Flow Cytometry of Escherichia coli Erik Boye and Harald B. Steen . . . . . . . . . . . . . . . . . . . . . . 11 3 Flow Cytometric Analysis of Heterogeneous Bacterial Populations Richard Allman, Richard Manchee and David Lloyd. . . . 27 4 On the Determination of the Size of Microbial Cells Using Flow Cytometry Hazel M. Davey, Chris L. Davey and Douglas B. Kell . . 49 5 Uses of Membrane Potential Sensitive Dyes with Bacteria David Mason, Richard Allman and David Lloyd . . . . . . .

The Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, protozoan and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.

Recently, there has been interest by regulators, the public and the manufacturers of wireless devices in the issues relating to the safety of radio frequency (RF) energy. These issues require an understanding of the scientific underpinnings of both physics of RF energy and cellular biology. This book is designed to provide precisely such cross-functional expertise. The editors of this book intend to provide a reliable source for a sound scientific understanding of the issues and to stimulate future scientific advances in this area. Therefore, the audience for this book includes such diverse groups as scientists, governmental policy-makers and regulatory bodies, representatives of industry and the public at large.

Environmental Chemistry is a relatively young science. Interest in this subject, however, is growing very rapidly and, although no agreement has been reached as yet about the exact content and limits of this interdisciplinary subject, there appears to be increasing interest in seeing environmental topics which are based on chemistry embodied in this subject. One of the first objectives of Environ mental Chemistry must be the study of the environment and of natural chemical processes which occur in the environment. A major purpose of this series on Environmental Chemistry, therefore, is to present a reasonably uniform view of various aspects of the chemistry of the environment and chemical reactions occurring in the environment. The industrial activities of man have given a new dimension to Environ mental Chemistry. We have now synthesized and described over five million chemical compounds and chemical industry produces about one hundred and fifty million tons of synthetic chemicals annually. We ship billions of tons of oil per year and through mining operations and other geophysical modifications, large quantities of inorganic and organic materials are released from their natural deposits. Cities and metropolitan areas of up to 15 million inhabitants produce large quantities of waste in relatively small and confined areas. Much of the chemical products and waste products of modern society are released into the environment either during production, storage, transport, use or ultimate disposal. These released materials participate in natural cycles and reactions and frequently lead to interference and disturbance of natural systems."

This volume written by 25 experts from industry and research provides a thorough overview of commerically important and environmentally mobile organosilicon materials. It outlines the structure, properties and applications of the four most significant material classes, and summarizes their environmental entry, transport, fate and impact. Detection and analytical methods are discussed both in the context of environmental assay and ecotoxicity testing along with some of the challenges. Measurement/estimation techniques and data available for several eco-pertinent properties of selected organosilicon compounds are summarized and limitations of the estimation and expertimental methods discussed. The environmental laws/regulations/trends in the U.S., Europe and Japan are discussed, along with their relevance to organosilicon materials. The book concludes with a broad overview of the major markets and global silicone producers, reviewing the industry's stewardship initiatives, relevant HES (health, environmental and safety) organizations and global cooperation.

Modern drugs are invented according to medical needs, making use of the latest innovations in technology. They are sophisticated, efficacious, and costly, but are they effective? Are they superior to existing - and cheaper - alternatives, and is this superiority reflected in increased cost-effectiveness? Are they socially more beneficial? These questions, and those related to the intriguing search for better quality of life, are addressed in this book by experts from the fields of medicine, epidemiology, economics, sociology and the pharmaceutical industry. The book describes the environmental situation in the United States and Europe in which pharmaceutical development takes place; it also explores the grounds for agreement as well as disagreement between the social and the economic evaluations of progress. It tackles the problem of outcome measurements, patients' behavior, quality of life, and individual value judgments and describes methodological boundaries in the socioeconomic evaluation of drugs.

Presented here is an account of industrial and general air pollution problems in view of air quality management, community and industrial health aspects, emission inventorying, emission and air quality measurement techniques, dispersion phenomena and control technologies. Moreover, several case studies from automotive and manufacturing processes as well as some country reports are presented. Finally, the global warming problem (greenhouse effect), atmospheric carbon dioxide build-up and radiation hazards involved in the atmosphere are discussed.

From a new perspective, namely focusing on the interaction of selenium and mercury, this thesis provides new insights into traditional research on biogeochemical cycles of mercury in soil-plant interaction and associated human exposure and risks. The subject of this thesis is both valuable and timely, providing essential information not only on selenium-mercury interaction in the soil-plant system but also on how to assess the combined benefits and risk of co-exposure to mercury and selenium. This work also sheds light on future aspects regarding prevention, remediation and risk management for environmental mercury contamination. Presenting high-quality papers published in leading international SCI journals such as Environmental Health Perspectives and Environmental Science & Technology and having been recognized with the Special Award of Presidential Scholarship Award and Excellent Doctoral Dissertations Prize of the Chinese Academy of Sciences (CAS), this thesis offers a valuable resource for scientific communities, policy-makers and non-experts who are interested in this field.

Dr. Hua Zhang works at the Norwegian Institute for Water Research (NIVA), Oslo, Norway.

This volume addresses the promise and challenges of employment, service roles and contexts in rehabilitation and mental health practice, developing readiness for employment, sustaining employment, and responding to the needs of people coping with a range of disabilities. The book is relevant to the education of human service professionals, and will enable practitioners to expand their awareness, understanding, and knowledge of the interface of rehabilitation and mental health.

A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.

Since questions about wireless phones andbrain cancer were first raised in early 1993, numerous scientificstudies and reviews have been conducted and published throughout the world with support from industry and government. The most comprehensive colloquium to date covering this science was co sponsored byt he International Committee on WirelessCommunication Health Research and Wireless Technology Research, LLC,a t the University "La Sapienza" ofR omein November 1995. Papers fromt hat colloquium with appropriate updates formt he foundation for the current volume. A follow up tothat colloquium isbeing planned fort he spring of 1999 byt he same group and thereport of that colloquium will bet he basis for Volume II ofthis series. As thescientific story about wireless phones and health effects continues to unfold over the next several years, it is important to evaluate thework ina context t hat isb eneficialt ot he enhancement ofpublic health. Two themesa re critical to an appropriate contextual understanding ofthis science.

The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today. The more frequent and faster travel that we experience today also escalates the risk of contraction and transmission of potentially deadly infections. This has created a very real and escalating risk for injuries and deaths. This is accentuated in the military and medical staff that is more frequently exposed to radiological, chemical, and biological agents in their normal working environment. Understanding the mechanisms whereby these toxic agents inflict damage to our bodies is essential to prepare us for these challenges. Much of the damage is inflicted through the generation of free radicals and non-radical oxidants which then act through oxidative mechanisms to injury the body. This volume will discuss the damage caused by these radiological, chemical, and biological environmental stressors, the mechanisms through which the damage can occur and the novel strategies that can be used to reduce the injury inflicted by these toxic compounds. Using basic and clinical research approaches, the contents of this book discuss new ideas for the development of bioactive products and environmental approaches to lessen or negate the biological damage inflicted by these noxious compounds.

Filarial nematodes constitute and important group of human pathogens in tropical regions of the world. Diseases associated with these worms are generally separated into two categories: filariasis, caused by infections of lymphatic dwelling parasites and onchocerciasis, or river blindness, caused by infections of Onchocerca volvulus. Other filariae specifically infect humans and it is likely that zoonotic filarial infections may alter the outcome of infections with human parasites. The chapters in this book will cover concepts that, in most instances, overlap all of these parasites as well as focus on new and emerging ideas. The Filaria, volume five of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

This book discusses the natural and anthropogenic determinants of the environment and their impact on human health. It throws light on the perspectives of climate change with case studies from Australia, India, Italy, and Latin America. Themes covered are ecology of antibiotic resistant microorganisms, pesticide and heavy metal (arsenic) problems in natural environment; molecular advances in understanding of microbial interactions; ecological studies of human/animal health and diseases; food security, technological developments and more. The various chapters incorporate both theoretical and applied aspects and may serve as baseline information for future research through which significant development is possible.

Like the first edition, the second edition of the Encyclopedia of Stress covers nearly every conceivable aspect and ramification of stress including a wide range of related topics such as neuroimmune interactions, cytokines, enzymatic disorders, effects on the cardiovascular system, immunity and inflammation, and physical illnesses. Over the last decade, scientists have presented convincing research showing that psychological stress increases vulnerability to disease. They now understand more clearly that stress may be the thread tying together illnesses that were previously believed to be unrelated. Bone loss, increased abdominal fat, and damaged memory cells in the hippocampus have been linked to elevated cortisol levels.
Building on the success of the first edition, this completely revised work surveys the vast amount of research generated in the past five years, resulting in a substantial revision with over 30% new material and over 100 new entries. Expanded sections include Animal Studies, Anxiety and Depression, Drugs, Depression, Disasters, and Psychological and Other Therapies.
Also available online via ScienceDirect (2007) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com.
* Timely update on the topic of Post-Traumatic Stress Disorder taking into account events such as terrorism and middle east wars
* Includes expanded coverage on anxiety and depression
* Incorporates entries on the advances in our knowledge ofimmunology, cytokines and cell mediated immunity involved in stress responses and autoimmune diseases such as multiple sclerosis and Type I diabetes

An important purpose of The Handbook of Environmental Chemistry is to aid the understanding of distribution and chemical reaction processes which occur in the environment. It is designed to serve as an important source for environmental scientists and decision-makers in industry, governmental and regulatory bodies. "Volume 3, Part E" of this series is dedicated to organometallic compounds, aluminium and to chemicals used in the rubber industry.

Excessive noise levels are generally acknowledged to have adverse effects on our environment. Studies indicate that excessive noise levels can cause fatigue in exposed individuals, lower efficiency and productivity, impaired speech communication, and hearing loss. Excessive noise is almost everywhere today - in the office, in schools, hospitals and other institutional facilities, in all classes of public buildings, and in our factories. INDUSTRIAL NOISE High noise levels in factories can make speech communication in the plant difficult and at times impossible. Foremen are often unable to hear warning shouts from co-workers. The problem of hearing loss due to excessive noise exposure is of particular concern to industry, and to the federal government. In the early 1970s, the United States Congress passed the Occupational Safety and Health Act (OSHA) which sets criteria for health hazards and established limits for noise exposure of industrial workers. The OSHA Noise Standard was amended in 1982 to require audiometric testing of all employees exposed to noise levels of 85 dB or above for eight hours. A NOISE IN COMMERCIAL AND INSTITUTIONAL BUILDINGS While noise levels in offices, stores, schools, and other commercial and institutional buildings seldom reach those encountered in many industrial environments, they often reach levels which are distracting to the occupants of such buildings. Impairment of speech communica tion among workers, or inversely the lack of speech privacy, are both deterrents to effiCiency and productivity and are detrimental to the occupants' comfort and sense of well-being."

Homeostasis. The health of an organism is influenced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It willbe answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer.
Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation.
Metastasis. Animal tumor models serve to understand the spread of the primary tumor cells to distant locations of the organism. Different types of tumors and metastases will be reviewed. "

Structure-Function Relationships of Human Pathogenic Viruses provides information on the mechanisms by which viruses enter the cell, replicate, package their DNA into capsids and mature into new virions. The relation between structural features and the pathogenicity and oncogenicity of some of the most relevant human viral pathogens are demonstrated and the acquisition of defense mechanisms through virus-host interactions are presented. In contrast to textbooks, this volume combines timely research data to provide a holistic view of viral pathogenesis. Furthermore Structure-Function Relationships of Human Pathogenic Viruses illustrates in a single volume the fundamental processes involved in viral life cycles using up-to-date information from research laboratories around the world. Knowledge of these processes is crucial to develop rationales for the design of future drugs. The timeliness of the data and the comprehensive yet concise approach this book takes in order to present the world of viral pathogens should make it a frontrunner in higher education and R&D.

This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds. As such, it is not only worthwhile but also vital to consider the enormous amounts of information that have been obtained by human "high cultures" in the past. Examples from the past (like quinine) or present (like artemisinin, a modern antimalarial drug) show that plant extracts may hold tremendous potential in the fight against parasites and/or against vector-transmitted agents of diseases.

Environmental sustainability issues in a fragile, semi-arid region and its coastal area, which experience climate changes from extreme drought conditions to the effects of hurricanes over a period of weeks to years, provide specific challenges for the ecosystems and the populations existing within the region. The research presented focuses on the problems and some solutions specific to the South Texas-Mexico border region, on both sides of the Rio Grande, focusing on water and air pollution. "

A there it is! guide to insects of medical and public health concern, mainly in the tropics. Each chapter covers identification, life cycle and habits of the causative stage and its medical/public health significance.

Skin diseases caused by aquatic organisms are continually on the increase owing to the great number of people who now converge on the hydrosphere for holidays, sports and professional activities. Aquatic skin diseases are no longer only a seasonal affliction but can be observed at any period, thanks to the tourist boom promoting aquatic holidaymaking throughout the year. This book aims to contribute to the knowledge of some aquatic animals that have only developed a poisonous apparatus to protect themselves and adapt to their environment, as well as of the various clinical pictures induced by different pathogenic mechanisms. Besides the afflictions caused by biotoxins, skin reactions to microscopic organisms present in seawater, freshwater, swimming pools and aquariums are described, together with some non-biotic forms induced by direct contact with salt and freshwater. A better knowledge of the aquatic environment may help people to enjoy this enthralling habitat at lesser risk.

American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T. cruzi is life-long, and 10-30% of persons who harbor the parasite chronically develop cardiac and gastrointestinal problems associated with the parasitosis. Although major progress has been made in recent years in reducing vector-borne and transfusion-associated transmission of T. cruzi, the burden of disability and death in persons chronically infected with the organism continues to be enormous. Eight to ten million persons born in countries in which Chagas disease is endemic currently reside in the United States, and epidemiologic and census data suggest that 50,000-100,000 are chronically infected with T. cruzi. The presence of these infected persons poses a risk of transmission of the parasite in the USA through blood transfusion and organ transplantation and several such cases have now been documented. American Trypanosomiasis, volume seven of World Class Parasites is written for students of tropical medicine, parasitology and public health, for researchers and practitioners alike who wish to bring themselves abreast of the status quo with respect to this disease. It is intended to supplement formal textbooks, in order to broaden and illuminate current areas of scientific and public health concern. Uniquely for T. cruzi, this book addresses parasite, vector and host biology, the pathogenesis of Chagas disease and current and prospective therapeutics and control strategies in a single volume.