Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

This book explores the challenges that confront leaders in government and industry when making decisions in the areas of environmental health and safety. Today, decision making demands transparency, robustness, and resiliency. However thoughtfully they are devised, decisions made by governments and enterprises can often trigger immediate, passionate public response. Expertise Under Scrutiny shows how leaders can establish organizational decision making processes that yield valid, workable choices even in fast-changing and uncertain conditions. The first part of the book examines the organizational decision making process, describing the often-contentious environment in which important environmental health and safety decisions are made, and received. The authors review the roles of actors and experts in the decision making process. The book goes on to address such topics as: * The roles of actors and experts in the decision making process * Ethics and analytics as drivers of good decisions * Why managing problems in safety, security, environment, and health Part II offers an outline for adopting a formal decision support structure, including the use of decision support tools. It includes a chapter devoted to ELECTRE (ELimination and Choice Expressing Reality), a multi-criteria decision analysis system. The book concludes with an insightful appraisal and analysis of the expertise, structure and resources needed for navigating well-supported, risk-informed decisions in our 21st Century world. Expertise Under Scrutiny benefits a broad audience of students, academics, researchers, and working professionals in management and related disciplines, especially in the field of environmental health and safety.

This book offers a selection of the best articles presented at the CUPUM (Computers in Urban Planning and Urban Management) Conference, held in the second week of July 2017 at the University of South Australia in Adelaide. It provides a state-of-the-art overview of the availability and application of planning support systems (PSS) in the context of smart cities, big data, and urban futures. Rapid advances in computing, information, communication and web-based technologies are reaching into all facets of urban life, creating new and exciting urban futures. With the universal adoption of networked computing technologies, data generation is now so massive and all pervasive in society that it offers unprecedented technological solutions for planning and managing urban futures. These technologies are essential to effective urban planning and urban management in an increasingly challenging world, with socially disruptive changes, more complex and sophisticated urban lives and the need for resilience to deal with the possibility of adverse future environmental events and climate change. The book discusses examples of these technologies which encompass, inter alia: 'smart urban futures', where cities with myriad sensors are networked with communication technologies that enable the city planners to monitor well-being and be responsive to citizens' needs to allow dynamic management in real-time; PSS that encompass new hardware, develop new indicators, applications and innovative ways of facilitating public and community involvement in the management and planning of urban areas; and urban modelling that draws on theory and the richness of data from the growing range of urban sensing and communication technologies to build a better understanding of urban dynamics, trends and 'what-if' scenario investigations, and to provide better tools for planning and policymaking.

This book provides an overview to researchers, graduate, and undergraduate students, as well as academicians who are interested in arsenic. It covers human health risks and established cases of human ailments and sheds light on prospective control measures, both biological and physico-chemical. Arsenic (As) is a widely distributed element in the environment having no known useful physiological function in plants or animals. Historically, this metalloid has been known to be used widely as a poison. Effects of arsenic have come to light in the past few decades due to its increasing contamination in several parts of world, with the worst situation being in Bangladesh and West Bengal, India. The worrying issue is the ingestion of arsenic through water and food and associated health risks due to its carcinogenic and neurotoxic nature. The impact of the problem is widespread, and it has led to extensive research on finding both the causes and solutions. These attempts have allowed us to understand the various probable causes of arsenic contamination in the environment, and at the same time, have provided a number of possible solutions. It is reported that more than 200 mineral species contain As. Generally, As binds with iron and sulfur to form arsenopyrite. According to one estimate from the World Health Organization (WHO), contextual levels of As in soil ranges from 1 to 40 mg kg-1. Arsenic toxicity is related to its oxidation state which is present in the medium. As is a protoplastic toxin, due to its consequence on sulphydryl group it interferes in cell enzymes, cell respiration and in mitosis. Exposure of As may occur to humans via several industries, such as refining or smelting of metal ores, microelectronics, wood preservation, battery manufacturing, and also to those who work in power plants that burn arsenic-rich coal.

The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.

This book discusses the latest findings on ensuring employees' safety, health, and welfare at work. It combines a range of disciplines - e.g. work physiology, health informatics, safety engineering, workplace design, injury prevention, and occupational psychology - and presents new strategies for safety management, including accident prevention methods such as performance testing and participatory ergonomics. The book, which is based on the AHFE 2018 International Conference on Safety Management and Human Factors, held on July 21-25, 2018, in Orlando, Florida, USA, provides readers, including decision makers, professional ergonomists and program managers in government and public authorities, with a timely snapshot of the state of the art in the field of safety, health, and welfare management. It also addresses agencies such as the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH), as well as other professionals dealing with occupational safety and health.

This clear-sighted volume synthesizes wide-ranging knowledge of human food consumption, food production systems, and sustainability to offer methods of improving the impact of food choices on people and the environment. The comprehensive coverage addresses myriad challenges and paradoxes (e.g., health-conscious food choices that put greater stress on the planet, hunger amidst plenty) associated with the production of sustainable, nutritious food. Direct and complex links between local and global issues are highlighted in innovative approaches to transforming food production from the farm to the table and from the policy desk to the real world. Chapters identify, examine, and offer realistic recommendations for achieving critical goals, among them: Supporting healthy people and communities within planetary boundaries Reduction and prevention of food waste Combining health and sustainability on the plate "Serving sustainable and healthy food to consumers and decision makers": from commitment to action. Investing in healthier and more sustainable production. Ensuring a healthy sustainable diet is a goal of all public policies. Towards Healthy and Sustainable Diets is geared toward professionals and policymakers dealing with food, nutrition, and environmental topics seeking new perspectives on longstanding issues in these interrelated areas. It also makes a suitable reference for students studying and conducting research in these areas.

This book shows how human factors and ergonomic principles have been transforming healthcare. It reports on the design of systems and devices to improve quality, safety, efficiency, and effectiveness in patient care, and discusses findings related to improving organizational outcomes in a healthcare setting, as well as approaches for analyzing and modeling those work aspects that are unique to healthcare. Based on the AHFE 2018 International Conference on Human Factors and Ergonomics in Healthcare and Medical Devices, held on July 21-25, 2018, in Orlando, Florida, USA, the book highlights the physical, cognitive and organizational aspects of human factors and ergonomic applications, presenting various perspectives, including those of clinicians, patients, health organizations, and insurance providers. The book is intended as a timely reference guide for researchers involved in the design of medical systems, healthcare professionals managing healthcare settings, as well as healthcare counselors and international health organizations.

This book systematically reviews the history of lead-free piezoelectric materials, including the latest research. It also addresses a number of important issues, such as new types of materials prepared in a multitude of sizes, structural and physical properties, and potential applications for high-performance devices. Further, it examines in detail the state of the art in lead-free piezoelectric materials, focusing on the pathways to modify different structures and achieve enhanced physical properties and new functional behavior. Lastly, it discusses the prospects for potential future developments in lead-free piezoelectric materials across disciplines and for multifunctional applications. Given its breadth of coverage, the book offers a comprehensive resource for graduate students, academic researchers, development scientists, materials producers, device designers and applications engineers who are working on or are interested in advanced lead-free piezoelectric materials.

This book is specifically designed to serve the community of postgraduates and researchers in the fields of epidemiology, health GIS, medical geography, and health management. It starts with the basic concepts and role of remote sensing, GIS in Kala-azar diseases. The book gives an exhaustive coverage of Satellite data, GPS, GIS, spatial and attribute data modeling, and geospatial analysis of Kala-azar diseases. It also presents the modern trends of remote sensing and GIS in health risk assessment with an illustrated discussion on its numerous applications.

This eye-opening study adds to the scarce scholarly literature on professional athletes, bringing empirical rigor to issues often clouded by mystery and hearsay. It identifies socioeconomic, demographic, and career variables as risk factors for mortality among former NBA and NFL players, along with hypotheses to be tested relating to elite athletes and other U.S. populations. A detailed multivariate analysis compares mortality factors, rates, and outcomes within and between the two leagues, comparing them also with the general U.S. male population. The findings and conclusions gleaned from this research offer possibilities for future research to improve health and quality of life in this specific athlete cohort, among athletes in general, in other groups, and in the larger society. Potential risk factors analyzed in this groundbreaking study: * Race * Body Mass Index (BMI) * U.S. birthplace region (Northeast, West, Midwest, South) * Years of playing experience * Playing position Mortality and Its Risk Factors among Professional Athletes will spark interest among professionals and researchers in public health, sports medicine, and epidemiology; current and former NBA and NFL players, their families, coaches, trainers, and union representatives; non-professional basketball and football players, athletes from other sports, and their families, coaches, and trainers; social scientists; policymakers; obesity researchers; parents of children who play contact sports; students, teachers, and researchers in occupational health and racial disparities; and health care providers.

This book intends to provide information about detection and health effects due to bacteria, fungi and viruses in indoor environments. The book will cover also information about preventive and protective measures to avoid health-hazardous. Case studies will be also addressed to enrich the book with the expertise of each invited author. The book also intends to fill a gap regarding information about all biologic agents, since most of the books available are dedicated to only one type of microorganisms. For various different biologic agents and metabolites this book will compile information about indoors presence, detection methods, exposure assessment and health effects. Several problems regarding the exposure of biologic agents will be presented through case studies, and also the implementation of preventive and protective measures to avoid/minimize exposure. Besides, all the book will focus on occupational health and/or public health point of view.

This book addresses up-to-date urban health issues from a systems perspective and provides an appealing integrated urban development strategy based on a 10-year global interdisciplinary research programme created by the International Council for Science (ICSU), and sponsored by the InterAcademy Partnership (IAP) and the United Nations University (UNU). The unique feature of this book is its "systems approach" to urban health and wellbeing: solution-oriented for science and society and not purely theoretical, it can be applied in the context of decision-making, and has the potential to unlock cities' unused potential by promoting health and wellbeing. Furthermore, the inter- and transdisciplinary urban issues addressed in this book are examined from a cross-sectoral perspective - e.g. the transport sector is addressed in connection with air pollution, respiratory and cardiovascular diseases and the loss of productivity. The interconnected thinking to urban health and wellbeing makes the book a particularly valuable resource. Decision makers in city administrations and civil society organizations from different geographical regions will find the book an informative and inspiring guide for delivering towards the goals of the New Urban Agenda, for which health can be the vital indicator of progress. Graduate students and researchers will be attracted by the case studies, systems methods and models provided in the book.

Polluted air and contaminated food and water are major causes of human health deterioration, but public health policy has long struggled to effectively address these concerns. This timely book--written for a wide audience of policy makers, researchers, and general readers--synthesizes what we already know about environmental hazards, identifies the gaps in our knowledge, and provides a roadmap for reducing human exposure to environmental pollution. With contributions from leading experts, Environmental Determinants of Human Health examines numerous pollutants, both inorganic and organic, in the context of their human health impacts. Individual chapters explore exposure pathways, macroeconomic impacts of human health deterioration, technological and non-technological methods for reducing exposures, monetary and non-monetary benefits from exposure reduction, and risk communication and awareness, including citizen participation approaches. This volume is a crucial text for policy makers requiring scientific justification for the development of new environmental regulations, scientists researching public health and environmental contamination, and members of the public interested in human health issues.

This book investigates different aspects of the relationship between "healthy cities" and "urban planning", examining various best practices in Europe. It uses the above as a starting point and investigates different aspects of healthy cities, examining various best practices in Europe. Capitalizing on ongoing trials, the chapters identify the policies that underlie plans and projects that have caused positive changes in local communities in terms of the quality of life and safety of inhabitants. From these best practices, the book deduces criteria and guidelines for planning healthy and safe cities.

This book focuses on the emerging health issues due to climate change, particularly emphasizing the situation in developing countries. Thanks to recent development in the areas of remote sensing, GIS technology, and downscale modeling of climate, it has now become possible to depict and predict the relationship between environmental factors and health-related event data with a meaningful spatial and temporal scale. The chapters address new aspects of environment-health relationship relevant to this smaller scale analyses, including how considering people's mobility changes the exposure profile to certain environmental factors, how considering behavioral characteristics is important in predicting diarrhea risks after urban flood, and how small-scale land use patterns will affect the risk of infection by certain parasites, and subtle topography of the land profile. Through the combination of reviews and case studies, the reader would be able to learn how the issues of health and climate/social changes can be addressed using available technology and datasets. The post-2015 UN agenda has just put forward, and tremendous efforts have been started to develop and establish appropriate indicators to achieve the SDG goals. This book will also serve as a useful guide for creating such an indicator associated with health and planning, in line with the Ecohealth concept, the major tone of this book. With the increasing and pressing needs for adaptation to climate change, as well as societal change, this would be a very timely publication in this trans-disciplinary field.

These proceedings summarize the best papers in each research area represented at the 2015 Annual Meeting of the German Gesellschaft fur Arbeitswissenschaft, held at Karlsruhe Institute of Technology (KIT) from February 26-28. The meeting featured more than 160 presentations and 30 posters reflecting the diversity of subject matter in the field of human and industrial engineering.

This book shows the advantages of using different perspectives and scientific backgrounds for developing support technologies that are integrated into daily life. It highlights the interaction between people and technology as a key factor for achieving this integration and discusses relevant methods, concepts, technologies, and applications suitable for interdisciplinary exchange and collaboration. The relationship between humans and technology has become much more inclusive and interdependent. This generates a number of technical, ethical, social, and practical issues. By gathering contributions from scholars from heterogeneous research fields, such as biomechanics, various branches of engineering, the social sciences, information science, psychology, and philosophy, this book is intended to provide answers to the main questions arising when support technologies such as assistance systems, wearable devices, augmented reality, and/or robot-based systems are constructed, implemented, interfaced and/or evaluated across different application contexts.

This book summarizes the early successes, drawbacks and accomplishments in cell biology and cell biotechnology achieved by the latest projects performed on the International Space Station ISS. It also depicts outcomes of experiments in tissue engineering, cancer research and drug design and reveals the chances that research in Space offers for medical application on Earth. This SpringerBriefs volume provides an overview on the latest international activities in Space and gives an outlook on the potential of biotechnological research in Space in future. This volume is written for students and researchers in Biomedicine, Biotechnology and Pharmacology and may specifically be of interest to scientists with focus on protein sciences, crystallization, tissue engineering, drug design and cancer research.

This book maps extreme temperature increase under dangerous climate change scenarios in Brazil and their impacts on four key sectors: agriculture, health, biodiversity and energy. The book draws on a careful review of the literature and climate projections, including relative risk estimates. This synthesis summarizes the state-of-the-art knowledge and provides decision-makers with risk analysis tools, to be incorporated in public planning policy, in order to understand climate events which may occur and which may have significant consequences.

This book presents a comprehensive study of the environmental situation prevailing in the areas located near the Koshkar-Ata (Kazakhstan) tailings dump and the development of rehabilitation measures taking into account the area's soil and climatic features. Given their impact on the local population's health, rehabilitation activities and their monitoring are vital for countries where nuclear power technologies are developed and where uranium mining industry wastes exist. Book analyzes the negative influences of the tailings on soil and vegetation cover on near-ground atmospheric layers and groundwater. Based on radiometric, field and laboratory analytical research methods, it presents quantitative information on the levels of pollution of the environment by radionuclides and chemical toxicants, and includes the results of constant monitoring of dust from radioactive and toxic wastes in the area. The book also offers recommendations for technical solutions for reclaiming radioactive tailing ponds, as well as for the development of disposal sites for radioactive waste in the tailing ponds, based on effective rehabilitation technologies developed at two control sites. The study attracted considerable interest from the Republic of Kazakhstan's state authorities and public organizations, and raised awareness of the need for rehabilitation measures at the KOSHKAR-ATA tailing pond. The monograph is intended for specialists in the field of environmental protection and radiation ecology, as well as senior undergraduate and graduate students, doctoral students and young scientists. This publication is recommended by the Academic Council of the L.N. Gumilyov Eurasian National University.

This book systematically reviews the history of lead-free piezoelectric materials, including the latest research. It also addresses a number of important issues, such as new types of materials prepared in a multitude of sizes, structural and physical properties, and potential applications for high-performance devices. Further, it examines in detail the state of the art in lead-free piezoelectric materials, focusing on the pathways to modify different structures and achieve enhanced physical properties and new functional behavior. Lastly, it discusses the prospects for potential future developments in lead-free piezoelectric materials across disciplines and for multifunctional applications. Given its breadth of coverage, the book offers a comprehensive resource for graduate students, academic researchers, development scientists, materials producers, device designers and applications engineers who are working on or are interested in advanced lead-free piezoelectric materials.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Mit dem Anstieg der Lebenserwartung in Europa geht ein Wandel der Erwerbs- und Lebensverlaufe einher, die durch Bruche und Wechsel der beruflichen Tatigkeiten gepragt sind. Ein zentrales Anliegen ist daher, jedem die Teilhabe am Erwerbsleben uber den gesamten Lebensverlauf zu ermoeglichen und zugleich soziale Rechte durch angemessenen sozialen Schutz zu gewahrleisten. Mit juristischen, sozialpolitischen und empirischen Analysen widmet sich dieses Buch dem Zusammenspiel verschiedener Sozialschutzmechanismen und ihren Schwierigkeiten, sich den neuen Entwicklungen anzupassen. Es prasentiert die Impulse europaischer Instanzen und die Antworten verschiedener europaischer Staaten auf die Herausforderung, Flexibilisierung der Beschaftigung und Modernisierung der Sozialschutzsysteme in Einklang zu bringen. Increasing life expectancy in Europe entails a remodelling of career development and life course, marked by discontinuities and changing professional activities. One of the concerns is ensuring that everybody may participate in gainful activities during his or her life course while also guaranteeing social rights through adequate social protection. By means of legal, socio-political and empirical analyses this book embarks on the interrelationship of different social protection mechanisms and the resulting difficulties of adapting to these new employment patterns. It presents European impulses and the reactions of several European states to the challenge of reconciling flexibility of employment and modernisation of social protection. L'augmentation de l'esperance de vie en Europe suscite un changement des modes de parcours professionnels et de vie constitues de ruptures et de conversions d'activite. L'une des preoccupations est de permettre a chacun de poursuivre une activite professionnelle tout au long de sa vie tout en pouvant beneficier d'une protection sociale adaptee. A travers des analyses juridiques, socio-politiques et empiriques, cet ouvrage aborde les interferences et les difficultes d'adaptation des mecanismes de protection sociale aux nouvelles evolutions. Il presente les impulsions europeennes et les choix effectues au niveau national pour concilier flexibilite de l'emploi et modernisation des systemes de protection sociale.

In the marine environment, single-celled, microscopic, plant-like organisms naturally occur in the well-lit surface layer of any body of water. These organisms, referred to as phytoplankton or microalgae, form the base of the food web upon which nearly all other marine organisms depend. Algal bloom is a rapid increase in or accumulation of the population of about 300 species of algae due to excess nutrients (eutrophication), and is of major global interest as it causes reduction in species diversity, abrupt changes in water quality, and discoloration of the water (green, yellow, brown or red) depending on the species of algae and the type of pigments they contain. Dying blooms can also be an environmental concern as when the cells sink and decay, bacteria break down the organic material, which in turn strips oxygen from the water. This microbial oxygen demand at times leads to very low oxygen levels in the bottom waters, harming aquatic life. Documentation of this sporadic high abundance of algae, together with the significant species richness of the diatoms, requires comprehensive studies in the Sundarban coastal environment, which is facing severe degradation due to natural & anthropogenic stressors. In addition, a better understanding of the effects of algal blooms on seafood quality, the complex biological, chemical and physical interactions and subsequent effects on trophodynamics is needed to develop strategies for effective coastal zone management. The book discusses the occurrence of harmful algal blooms (HABs) caused by the dinoflagellates of the genus Alexandrium and Karenia, or diatoms of the genus Pseudo-nitzschia, which have large and varied impacts on marine ecosystems (such as large-scale marine mortality events that have been associated with various types of shellfish poisonings) depending on the species involved, the environment where they are found, and the mechanism by which they exert negative effects. HABs represent a major environmental problem in all regions of the U.S., and their occurrence is on the rise due to increased nutrient pollution. HABs have severe impacts on human health, aquatic ecosystems, and the economy. Such blooms, known colloquially as red tides due to their red or brown hues, are increasing in frequency and magnitude worldwide as a result of changes in oceanic climate, increased coastal eutrophication and enhanced long-distance dispersal in ballast water. As such, the book offers an in-depth account of the complex biological, chemical and physical interactions of the algal blooms (both innocuous and harmful ones). It also discusses the highly topical issue of the impact of global climate change on the frequency and severity of HABs in the context of alterations in temperature, stratification, light and ocean acidification. Focusing on both basic and applied limnology, this book is a reliable and up-to-date reference resource for students, teachers and researchers engaged in the field of coastal research/management at regional and global scales.