This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

This volume provides an overview of the occurrence and fate of emerging contaminants, discusses advanced chemical analysis methods, toxicological and ecotoxicological effects as well as human exposure. One focus is on pharmaceuticals, in particular antibiotics, and the problems associated with their increased use in hospitals. Other covered emerging contaminants occurring e.g. in food, water, air or soil include brominated flame retardants, polar pesticides, phthalates, phosphate esters, perfluorinated compounds, personal care products, musk fragrances, disinfection byproducts, illicit drugs, and nanomaterials. The chapters written by experts are a valuable source of information for a broad audience, such as analytical chemists, environmental chemists and engineers, toxicologists, ecotoxicologists and epidemiologists working already in this field as well as newcomers.

Workers and their families, employers, and society as a whole benefit when providers deliver the best quality of care to injured workers and when they know how to provide effective services for both prevention and fitness for duty and understand why, instead of just following regulations. Designed for professionals who deliver, manage, and hold oversight responsibility for occupational health in an organization or in the community, Occupational Health Services guides the busy practitioner and clinic manager in setting up, running, and improving healthcare services for the prevention, diagnosis, treatment, and occupational management of work-related health issues. The text covers: an overview of occupational health care in the US and Canada: how it is organized, who pays for what, how it is regulated, and how workers' compensation works how occupational health services are managed in practice, whether within a company, as a global network, in a hospital or medical group practice, as a free-standing clinic, or following other models management of core services, including recordkeeping, marketing, service delivery options, staff recruitment and evaluation, and program evaluation depth and detail on specific services, including clinical service delivery for injured workers, periodic health surveillance, impairment assessment, fitness for duty, alcohol and drug testing, employee assistance, mental health, health promotion, emergency management, global health management, and medico-legal services. This highly focused and relevant combined handbook and textbook is aimed at improving the provision of care and health protection for workers and will be of use to both managers and health practitioners from a range of backgrounds, including but not limited to medicine, nursing, health services administration, and physical therapy.

This book offers a meaningful and practicable guide to better management of arsenic problems in the groundwater of the Gangetic Plain. It gathers contributions from distinguished researchers who have been actively working in the area for over a decade. The arsenic contamination of groundwater is a growing concern in the central Gangetic Plain, where the local population's main sources of fresh water are surface water, groundwater and rain water; of these sources, only the last two generally meet the most important criteria for drinking water in their natural state. Natural geological changes are presumed to be the primary reason for arsenic contamination in this region. Further, most of the people living in this area have developed the habit of drinking water (groundwater) from the arsenic-contaminated tubewells in many parts of the region. As a result, many are suffering from arsenicosis and many more are at risk. Since the cause of arsenic contamination in groundwater still remains unclear, this book seeks to address the arsenic issue in this region by pursuing a holistic and systematic scientific approach. Accordingly, it delineates various sources, processes, hypotheses and remedial approaches that are needed to manage the arsenic contamination in the Central Gangetic Plain.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. New edition of a comprehensive text: an ideal resource for the occupational health professional! An updated and comprehensive guide to occupational and environmental injuries and illnesses, their diagnosis and treatment, and preventive measures in the workplace and community. Complete and concise, this clinically focused book is the go-to reference for health care professionals in all specialties who diagnose and treat acute and chronic occupational and environmental injuries and illnesses. In addition to clinical management and toxicology, the text covers important aspects of multidisciplinary occupational health and safety practice including ethical principles, disability management, workers' compensation, medical monitoring, and health risk assessment. This new edition features new chapters on the impact of climate change on workers, the changing nature of work, Total Worker Health, workplace violence, pediatric environmental health, genetic toxicology and responder safety and health latest approaches to prevent workplace-related injuries through the application of ergonomic principles updated practical information on the toxic properties and clinical manifestations of industrial materials and environmental agents.

This book offers a selection of the best articles presented at the CUPUM (Computers in Urban Planning and Urban Management) Conference, held in the second week of July 2017 at the University of South Australia in Adelaide. It provides a state-of-the-art overview of the availability and application of planning support systems (PSS) in the context of smart cities, big data, and urban futures. Rapid advances in computing, information, communication and web-based technologies are reaching into all facets of urban life, creating new and exciting urban futures. With the universal adoption of networked computing technologies, data generation is now so massive and all pervasive in society that it offers unprecedented technological solutions for planning and managing urban futures. These technologies are essential to effective urban planning and urban management in an increasingly challenging world, with socially disruptive changes, more complex and sophisticated urban lives and the need for resilience to deal with the possibility of adverse future environmental events and climate change. The book discusses examples of these technologies which encompass, inter alia: 'smart urban futures', where cities with myriad sensors are networked with communication technologies that enable the city planners to monitor well-being and be responsive to citizens' needs to allow dynamic management in real-time; PSS that encompass new hardware, develop new indicators, applications and innovative ways of facilitating public and community involvement in the management and planning of urban areas; and urban modelling that draws on theory and the richness of data from the growing range of urban sensing and communication technologies to build a better understanding of urban dynamics, trends and 'what-if' scenario investigations, and to provide better tools for planning and policymaking.

Adds three new chapters (constructed wetlands, stream sediments, and rice production systems) and is updated throughout Examines the adaptation of wetland plants to varying anaerobic soil conditions Provides the basic concepts involved in biogeochemical cycling of nutrients and contaminants in wetlands as related to environmental significance and ecological functions Examines the role of microbial processes in sulfate reduction, denitrification, and methane production Provides case studies for key biogeochemical processes governing wetland function in freshwater wetlands

Microbial or biological degradation has long been the subject of active concern, and the rapid expansion and growing sophistication of various industries in the last century has significantly increased the volume and complexity of toxic residues of wastes. These can be remediated by plants and microbes, either natural origin or adapted for a specific purpose, in a process known as bioremediation. The interest in microbial biodegradation of pollutants has intensified in recent years in an attempt to find sustainable ways to clean contaminated environments. These bioremediation and biotransformation methods take advantage of the tremendous microbial catabolic diversity to degrade, transform or accumulate a variety of compounds, such as hydrocarbons, polychlorinated biphenyls, polaromatic hydrocarbons pharmaceutical substances, radionuclides and metals. Unlike conventional methods, bioremediation does not physically disturb the site. This book describes the basic principles of biodegradation and shows how these principles are related to bioremediation. Authored by leading, international environmental microbiologists, it discusses topics such as aerobic biodegradation, microbial degradation of pollutants, and microbial community dynamics. It provides valuable insights into how biodegration processes work and can be utilised for pollution abatement, and as such appeals to researchers and postgraduate students as well as experts in the field of bioremediation.

This book addresses the major neglected tropical diseases (NTDs) - based on their prevalence and the years of healthy life lost to disability - in Latin American and Caribbean countries. These include Chagas disease, leishmaniasis, hookworm infection, and other soil-transmitted helminth infections, followed by dengue, schistosomiasis, leishmaniasis, leprosy, cysticercosis, bartonellosis, Plasmodium vivax malaria, and onchocerciasis. Topics like disease burden, major manifestations and approaches to the control and elimination of NTDs in Latin America and the Caribbean are discussed in detail. As such, the book will be of general interest to basic researchers and clinicians engaged in infectious disease, tropical medicine, and parasitology, and a must-have for scientists specialized in the characteristics of this region of the world.

A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system.

Three main themes are discussed:

• Nanoparticle sources and production
• Nanoparticle inhalation and deposition
• Toxicological and medical consequences of nanoparticles

Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.

This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds. As such, it is not only worthwhile but also vital to consider the enormous amounts of information that have been obtained by human "high cultures" in the past. Examples from the past (like quinine) or present (like artemisinin, a modern antimalarial drug) show that plant extracts may hold tremendous potential in the fight against parasites and/or against vector-transmitted agents of diseases.

This publication characterizes the environmental burden of disease in the United Arab Emirates (UAE), measured by the excess number of deaths and illnesses in the population due to exposure to environmental hazards. The robust methods used in this risk analysis can be applied to any country or region. This publication documents the systematic, multi-step process used to identify environmental priorities and the detailed methods used to quantify the disease burden attributable to each risk. Based on the results of the burden of disease assessment, the publication summarizes the subsequent steps that are recommended to further reduce the burden of disease resulting from various environmental risk factors.

Authors and Contributors
This book represents the synthesis of research carried out by a large, interdisciplinary team from several institutions and multiple nations between June 2008 and June 2011.The lead authors are responsible for weaving together the pieces prepared by the team.Nonetheless, this book would not have been possible without major contributions from each team member.The list below shows contributors to each chapter.Following this list are biographies of all of the authors and contributors.

Lead Authors

Jacqueline MacDonald Gibson, Frederic J. P. Launay, Jens T. W. Thomsen, Angela Brammer, Christopher Davidson

Additional Contributors (by Chapter)

Chapter 2: Prioritizing Environmental Risks to Health
Henry H. Willis, Aimee Curtright, Gary Cecchine, Zeinab S. Farah, Sandra A. Geschwind, Jianhui Hu, Ying Li, Melinda Moore, Sarah Olmstead, Hanine Salem, Regina A. Shih, J. Jason West

Chapter 3: Assessing the Environmental Burden of Disease: Method Overview
TiinaFolley, Elizabeth S. Harder, MejsHasan

Chapter 4: Burden of Disease from Outdoor Air Pollution
Ying Li, GavinoPuggioni, PrahladJat, MejsHasan, Marc Serre, Kenneth G. Sexton, J. Jason West, SaravananArunachalam, Uma Shankar, William Vizuete, Mohammed ZuberFarooqui

Chapter 5: Burden of Disease from Indoor Air Pollution
Chris B. Trent

""

Chapter 6: Burden of Disease from Occupational Exposures
TiinaFolley, LeenaA. Nylander-French

Chapter 7: Burden of Disease from Climate Change
Richard N. L. Andrews, Leslie Chinery, Elizabeth S. Harder, J. Jason West

Chapter 8: Burden of Disease from Drinking Water Contamination
Gregory W. Characklis, Joseph N. LoBuglio

Chapter 9: Burden of Disease from Coastal Water Pollution
Gregory W. Characklis, Leigh-Anne H. Krometis, Joseph N. LoBuglio
Chapter 10: Burden of Disease from Soil and Groundwater Contamination
Chidsanuphong Chart-asa, Stephanie Soucheray-Grell

Chapter 11: Burden of Disease from Produce and Seafood Contamination
Leigh-Anne H. Krometis, Leslie Chinery"

This progressive reference redefines qualitative research as a crucial component of evidence-based practice and assesses its current and future impact on healthcare. Its introductory section explains the value of sociocultural context in case conceptualization, and ways this evidence can be integrated with quantitative findings to inform and transform practice. The bulk of the book's chapters review qualitative research in diverse areas, including pain, trauma, heart disease, COPD, and disabling conditions, and examine ways of effectively evaluating and applying qualitative data. This seismic shift in perception moves the healing professions away from traditional one-size-fits-all thinking and toward responsive, patient-centered care. Among the topics in the Handbook: *Examining qualitative alternatives to categorical representation. *The World Health Organization model of health: what evidence is needed? *Qualitative research in mental health and mental illness. *Qualitative evidence in pediatrics. *The contribution of qualitative research to medication adherence. *Qualitative evidence in health policy analysis. The Handbook of Qualitative Health Research for Evidence-Based Practice offers health and clinical psychologists, rehabilitation specialists, occupational and physical therapists, nurses, family physicians and other primary care providers new ways for understanding patients' health-related experiences and opens up new ways for developing interventions intended to improve health outcomes.

Environmental sustainability issues in a fragile, semi-arid region and its coastal area, which experience climate changes from extreme drought conditions to the effects of hurricanes over a period of weeks to years, provide specific challenges for the ecosystems and the populations existing within the region. The research presented focuses on the problems and some solutions specific to the South Texas-Mexico border region, on both sides of the Rio Grande, focusing on water and air pollution. "

This book examines the policy and politics of two health risks, which have recently become prominent social issues in many countries. One is the issue of asbestos as an environmental risk to humans, and another is that of bovine spongiform encephalitis (BSE), or mad cow disease as an animal disease, and of its variant Creutzfeldt-Jakob disease (CJD) as a human food risk. Employing a set of analytical frameworks in political science, each case study explores how the issues emerged, agendas got set, alternatives were chosen, and policies were implemented. Through the analysis, it is examined how safety and public reassurance were pursued in the countries studied (Japan, the UK, France the USA, and Korea). Exploration of the successes and failures in their efforts discloses the key elements to successful health risk management.

Antimicrobial resistance is recognised among the world’s most challenging problems. Despite its global spread, Africa, specifically sub-Saharan Africa, is the most affected by this malaise. Poor living conditions and inadequate access to sanitation and potable water supplies are among contributing factors that have influenced a high disease burden on the continent, requiring extensive antimicrobials. Weak health systems and the absence of firm policies further aggravate the problem, as the use of antimicrobials is mostly unregulated. The increasing demand for animal protein to meet the starving populations’ demands has also influenced the use of these antimicrobials, including those banned on other continents, for food animal production. The ripple effect of indiscriminate use in humans and animals is the massive discharge of antimicrobials, their residues, antimicrobial-resistant microorganisms and their associated genes into the environment.  This 14-chapter unique masterpiece presents the AMR problem in African, addressing the various compartments of the One Health – humans, animals, and the environment, to illustrate the need for concerted efforts in the fight against AMR, especially in Africa. Authors from the four cardinal points present diverse aspects of AMR in Africa, starting with behavioural and social drivers of AMR in Africa. Antimicrobial stewardship in an African context is also discussed. AMR in humans is presented through studies on antibiotic-resistant neonates and nontyphoidal Salmonella infections and the clinical relevance of the genetics of viral resistance. Topics on AMR in mastitis, biosecurity in animal farming and the linkage between disinfectants and AMR are discussed. The environmental dimension of AMR is discussed, notably in the aquatic environment, and its implication for aquaculture and irrigation and using nanomaterials to treat polluted waters from such environments are highlighted. Finally, Africa’s rich floral diversity is portrayed as an eco-friendly and cost-effective approach to combat AMR. Hopefully, the work presented will spur greater collaboration between scientists, environmental, animal and human health practitioners, the general population, and policymakers to assimilate and implement the One Health approach to combating AMR, rather than working in silos on their various sectors

This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

From a new perspective, namely focusing on the interaction of selenium and mercury, this thesis provides new insights into traditional research on biogeochemical cycles of mercury in soil-plant interaction and associated human exposure and risks. The subject of this thesis is both valuable and timely, providing essential information not only on selenium-mercury interaction in the soil-plant system but also on how to assess the combined benefits and risk of co-exposure to mercury and selenium. This work also sheds light on future aspects regarding prevention, remediation and risk management for environmental mercury contamination. Presenting high-quality papers published in leading international SCI journals such as Environmental Health Perspectives and Environmental Science & Technology and having been recognized with the Special Award of Presidential Scholarship Award and Excellent Doctoral Dissertations Prize of the Chinese Academy of Sciences (CAS), this thesis offers a valuable resource for scientific communities, policy-makers and non-experts who are interested in this field.

Dr. Hua Zhang works at the Norwegian Institute for Water Research (NIVA), Oslo, Norway.

Reports on waste valorization in the winemaking industry and converting the waste into more useful products including oils, antioxidants and other valuable materials. Explores research which contributes to environmental sustainability and circular economy in the winemaking industry. Describes other ways to reduce the ecological footprint of the wine industry such as using less fertilizer, more benign pesticides and reduction of water footprint. Proposes options for a potential wine waste biorefining. Reviews alternative uses of agro-industrial wine wastes as sources of additives for the food, cosmetic and pharmaceutical industries.

Humans are diurnal organisms whose biological clock and temporal organization depend on natural light/dark cycles. Changes in the photoperiod are a signal for seasonal acclimatization of physiological and immune systems as well as behavioral patterns. The invention of electrical light bulbs created more opportunities for work and leisure. However, exposure to artificial light at night (LAN) affects our biological clock, and suppresses pineal melatonin (MLT) production. Among its other properties, MLT is an antioncogenic agent, and therefore its suppression increases the risks of developing breast and prostate cancers (BC&PC). To the best of our knowledge, this book is the first to address the linkage between light pollution and BC&PC in humans. It explains several state-of-the-art theories, linking light pollution with BC&PC. It also illustrates research hypotheses about health effects of light pollution using the results of animal models and population-based studies.

Laboratory Experiments in Trace Environmental Quantitative Analysis is a collection of student-tested experiments that introduce important principles that underlie various laboratory techniques in the field of trace environmental organics and inorganics quantitative analysis. It crosses the more traditional academic disciplines of environmental science and analytical chemistry. The text is organized to begin with minimally rigorous session/experiments and increase in rigor as each session/experiment unfolds. Each experiment features learning objectives, expected student outcomes, and suggestions for further study. Additional features include: Students are introduced to the principles and laboratory practice of instrumental analysis (determinative techniques) that are clearly presented. Students are carefully taken through various ways to prepare samples for trace quantitative analysis (sample prep techniques). Safety warnings are listed within each experiment. Students are introduced to all three types of instrument calibration: external, internal and standard addition. Instructors who are responsible for laboratory courses in analytical chemistry with potential application to environmental sample matrices will find this textbook of value. Graduate programs in environmental science and engineering will also greatly benefit from the content.