This book discusses the natural and anthropogenic determinants of the environment and their impact on human health. It throws light on the perspectives of climate change with case studies from Australia, India, Italy, and Latin America. Themes covered are ecology of antibiotic resistant microorganisms, pesticide and heavy metal (arsenic) problems in natural environment; molecular advances in understanding of microbial interactions; ecological studies of human/animal health and diseases; food security, technological developments and more. The various chapters incorporate both theoretical and applied aspects and may serve as baseline information for future research through which significant development is possible.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

This book is a collection of policy briefs produced from research presented at the 16th Conference on Urban Health in Xiamen, China, November 4-8, 2019, under the theme "People Oriented Urbanisation: Transforming Cities for Health and Well-Being", co-organized by the Urban Health and Wellbeing (UHWB) programme of the International Science Council (ISC). The UHWB programme takes an interdisciplinary, cross-sectoral and systemic view on issues of health and wellbeing in cities which include the urban economy and finance systems, education, employment, mobility and transport, food, energy and water resources, access to public services, urban planning, public spaces and urban green, as well as social inclusion. Contributions to this book have been made by scientists from multidisciplinary research fields. The policy briefs in this book present the background and context of an urban health issue, research findings and recommendations for policy/decision-makers and action-takers. In some cases, they inform about relevant events and developments from the science community or important opinion pieces which address health emergencies, like the current COVID-19 pandemic. The book is intended for citizens and political decision-makers, who are interested in systems perspectives on urban health and wellbeing, examples of how to deal with the increasing complexity of cities and the accompanying environmental and social impacts of increasing urbanization. Furthermore, it hopes to inspire decision-makers to facilitate finding solutions, in order to reach the goal of advancing global urban health and wellbeing.

This textbook provides students and the broader aviation community with a complete, accessible guide to the subject of human factors in aviation. It covers the history of the field before breaking down the physical and psychological factors, organizational levels, technology, training, and other pivotal components of a pilot and crew's routine work in the field. The information is organized into easy-to-digest chapters with summaries and exercises based on key concepts covered, and it is supported by more than 100 full-color illustrations and photographs. All knowledge of human factors required in aviation university studies is conveyed in a concise and casual manner, through the use of helpful margin notes and anecdotes that appear throughout the text.

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

This issue of Clinics in Chest Medicine, Guest Edited by Carrie A. Redlich, MD, MPH, Paul Blanc, MD, MSPH, Mridu Gulati, MD, and Ware Kuschner, MD, will focus on Occupational and Environmental Lung Diseases, with article topics including: asthma, hypersensitivity pneumonitis, and other immune-mediated lung disease; Work-exacerbated asthma; Occupational COPD; Indoor fuel exposure and the lung in both the developed and developing worlds; New (and newly recognized) occupational and environmental causes of selected chronic parenchymal and terminal airway diseases; Occupational rhinitis and other work-related upper respiratory tract conditions; Military service and lung disease; Ambient air pollution; Protecting the lungs from microbes, particles and other inhalational exposures; and Exhaled breath and induce sputum analysis in assessing the effects of occupational and environmental exposures.

It is extremely important that physicians be aware of the wide spectrum of tropical, infectious and parasitic diseases their patients may have been exposed to while traveling abroad. This volume of the ID Clinics is edited by 3 internationally renowned infectious disease physicians and provides an authoritative and comprehensive treatise on Travel Medicine.

This book is an overview of the hazards of firefighting, the health risks of exposure to combustion products that characterize firefighting, the science behind interpreting these risks for purposes of identifying diseases as work-related, and the legal and policy implications of adopting legislated "presumption" for purposes of compensation. The emphasis of the book will be on the risk of cancer, cardiovascular disease, traumatic hazards, and disabling psychosocial adjustment following major incidents. Several new studies have appeared recently, including the largest study of firefighters ever done, by the National Institute of Occupational Health and Safety (NIOSH). They evidence supports the conclusion that firefighters face significant occupational health risks in addition to the obviously severe safety hazards.

This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy. The authors explore the medicinal chemistry efforts that gave rise to currently launched drugs and new anti-HIV agents, and they also highlight the latest vaccine and drug developments in the clinical management of the Ebola Virus Disease, ignited by the 2014-2016 outbreak. This work has an interdisciplinary appeal and will engage scholars and professionals in the burden of communicable diseases.

Exposure to ambient air pollutants, both indoors and outdoors has been associated with the exacerbation and also in the etiology of diverse human diseases. This book offers an overview of our current understanding of air pollution health risks and how this knowledge is being used in the regulatory, therapeutic intervention measures to protect the public health and reduce the disease burden caused by acute and long-term exposure to air pollutants. Air Pollution and Health Effects provides readers with a comprehensive understanding of air pollution health risks, morbidity and the global disease burden, whilst also delivering critical review on state of the art research so as to gain a fundamental understanding of the biological mechanisms involved in the etiology of air pollution-induced diseases. Chapters range from pregnancy outcomes and pre-term birth, carcinogens in the ambient aerosol and the health consequences of indoor biomass burning. Special emphasis is placed on regional and local air pollution and its impact on global health along with suitable preventive and interventional measures. With contributions from international experts in the field this volume is a valuable guide for researchers and clinicians in toxicology, medicine and public health as well as industry and government regulatory scientists involved in health protection.

This book provides an overview to researchers, graduate, and undergraduate students, as well as academicians who are interested in arsenic. It covers human health risks and established cases of human ailments and sheds light on prospective control measures, both biological and physico-chemical. Arsenic (As) is a widely distributed element in the environment having no known useful physiological function in plants or animals. Historically, this metalloid has been known to be used widely as a poison. Effects of arsenic have come to light in the past few decades due to its increasing contamination in several parts of world, with the worst situation being in Bangladesh and West Bengal, India. The worrying issue is the ingestion of arsenic through water and food and associated health risks due to its carcinogenic and neurotoxic nature. The impact of the problem is widespread, and it has led to extensive research on finding both the causes and solutions. These attempts have allowed us to understand the various probable causes of arsenic contamination in the environment, and at the same time, have provided a number of possible solutions. It is reported that more than 200 mineral species contain As. Generally, As binds with iron and sulfur to form arsenopyrite. According to one estimate from the World Health Organization (WHO), contextual levels of As in soil ranges from 1 to 40 mg kg-1. Arsenic toxicity is related to its oxidation state which is present in the medium. As is a protoplastic toxin, due to its consequence on sulphydryl group it interferes in cell enzymes, cell respiration and in mitosis. Exposure of As may occur to humans via several industries, such as refining or smelting of metal ores, microelectronics, wood preservation, battery manufacturing, and also to those who work in power plants that burn arsenic-rich coal.

Stress is a universal phenomenon that impacts adversely on most people. Following on the heels of "Stress Science: Neuroendocrinology" and "Stress Consequences: Mental, Neuropsychological and Socioeconomic," this third derivative volume will provide a readily accessible and affordable compendium that explains the phenomenon of stress as it relates physically and mentally to war, conflict and disaster. The first section will be dedicated to study of the link between stress and various forms of conflict. Specific instances of conflict will be discussed - the Gulf wars, Korea, Hiroshima bombing, the Holocaust, 9/11, Northern Ireland, terrorism in general, torture. The second section will explore the stress impact of more general physical disasters such as airline and vehicle accidents, earthquakes, floods, and hurricanes. The final section will focus on the clinical relationship between conflict stress and various mental diseases - PTSD, suicide, disaster syndrome, etc - as well as the adverse impact of stress on human physical health in general.

Comprised of about 100 top articles selected from Elsevier s "Encyclopedias of Stress," the volume will provide a valuable desk reference that will put relevant articles readily at the fingertips of all scientists who consider stress.

Chapters offer impressive and unique scope with topics addressing the relationship between stress generated by war, conflict and disaster and various physical/mental disorders Richly illustrated with over 200 figures, dozens in color Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"

This is the first book to summarize all aspects of allergenic pollen: production, atmospheric distribution, and health impacts, as well as the means of monitoring and forecasting these phenomena. Based on a four-year effort by a large group of leading European scientists, this book highlights the new developments in research on allergenic pollen, including the modelling prospects and effects of climate change. The multidisciplinary team of authors offers insights into the latest technology of detection of pollen and its allergenic properties, forecasting methods, and the influence of allergenic pollen on the population. The comprehensive coverage in this book makes it an indispensible volume for anyone dealing with allergenic pollen worldwide. Readers involved in environmental health, aerobiology, medicine, and plant science will find this book of interest.

This book brings together the most current thinking and research on educator stress and how education systems can support quality teachers and quality education. It adopts an occupational health perspective to examine the problem of educator stress and presents theory-driven intervention strategies to reduce stress load and support educator resilience and healthy school organizations. The book provides an international perspective on key challenges facing educators such as teacher stress, teacher retention, training effective teachers, teacher accountability, cyber-bullying in schools, and developing healthy school systems. Divided into four parts, the book starts out by introducing and defining the problem of educator stress internationally and examining educator stress in the context of school, education system, and education policy factors. Part I includes chapters on educator mental health and well-being, stress-related biological vulnerabilities, the relation of stress to teaching self-efficacy, turnover in charter schools, and the role of culture in educator stress. Part II reviews the main conceptual models that explain educator stress while applying an occupational health framework to education contexts which stresses the role of organizational factors, including work organization and work practices. It ends with a proposal of a dynamic integrative theory of educator stress, which highlights the changing nature of educator stress with time and context. Part III starts with the definition of what constitute healthy school organizations as a backdrop to the following chapters which review the application of occupational health psychology theories and intervention approaches to reducing educator stress, promoting teacher resources and developing healthy school systems. Chapters include interventions at the individual, individual-organizational interface and organizational levels. Part III ends with a chapter addressing cyber-bullying, a new challenge affecting schools and teachers. Part IV discusses the implications for research, practice and policy in education, including teacher training and development. In addition, it presents a review of methodological issues facing researchers on educator stress and identifies future trends for research on this topic, including the use of ecological momentary assessment in educator stress research. The editors' concluding comments reflect upon the application of an occupational health perspective to advance research, practice and policy directed at reducing stress in educators, and promoting teacher and school well-being.

This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in Europe and Central Asia. This book discusses in detail the pathology, diagnostics and control approaches of the most important neglected pathogens occurring in these geographical regions. Each chapter focuses on one specific disease or group of related diseases, and provides the reader with in-depth insights into the topic. This volume addresses researchers in Microbiology and Biomedicine as well as clinicians and public health officials working in affected regions.

Environmental professionals can no longer simply publish research in technical journals. Informing the public is now a critical part of the job. Environmental Communication demonstrates, step by step, how it's done, and is an essential guide for communicating complex information to groups not familiar with scientific material. It addresses the entire communications process, from message planning, audience analysis and media relations to public speaking - skills a good communicator must master for effective public dialogue. Environmental Communication provides all the knowledge and tools you need to reach your target audience in a persuasive and highly professional manner.

"This book will certainly help produce the skills for environmental communications sorely needed for industry, government and non-profit groups as well as an informed public." Sol P. Baltimore, Director, Environmental Communications and Adjunct faculty, Hazardous Waste management program, Department of Chemical Engineering, College of Engineering, Wayne State University, Detroit, Michigan.

"All environmental education professionals agree that the practice of good communications is essential for the success of any program. This book provides practical skills for this concern." Ju Chou, Associate Professor, Graduate Institute of Environmental Education National Taiwan Normal University Taipei, Taiwan

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine.
He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates.
* Focuses on Zuntz's contribution to high altitude physiology and aviation medicine

This book includes a collection of chapters illustrating the application of geochemical methods to investigate the interactions between geological materials and fluids with humans. Examples include the incorporation and human health effects of inhaling lithogenic materials, the reactivity of biological fluids with geological materials, and the impact on nascent biomineral formation. Biomineralization is investigated in terms of mineralogy, morphology, bone chemistry, and pathological significance with a focus on the health impacts of "foreign" geological/environmental trace element incorporation. One of the contribution is devoted to particulate matter, the presence of metals and metalloids in the environment, and the possibility of using human hair as a biomarker between environmental/geological exposure and human bioincorporation. Other chapters focus on the last advances on the analytical methods and instrumentational approaches to investigating the chemistry of biological fluids and tissues.

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

In recent years many introductory textbooks on clinical trial methodology have been published, some of which are excellent, in addition to a very extensive specialist literature. Nevertheless, here is a new book on methods and issues in clinical research. The objectives can be summarized in three points. 1. Integrate medical and statistical components of clinical research. 2. Do justice to the operational and practical requirements of clinical research. 3. Give space to the ethical implications of methodological issues in clinical research.

The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species. The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.

A detailed coverage of the logistic, administrative and legal aspects of clinical research is outside the scope of this book. However, throughout the book we keep reminding the reader of these aspects because, as already mentioned, we firmly believe they have a crucial role in determining the success of a study. The history of clinical research is paved with relics of studies started with great pomp, riding great ideas and great hopes, which drowned miserably because of inadequate logistical preparation. In our experience, the excessive complexity of a clinical trial is the single most frequent cause of failure: the study is perfect on paper, but impossible to implement by patients and staff alike. The distance between the principal investigators and the reality of clinical research in its day-to-day practice is often the main cause of such disasters. We warmly encourage everyone involved in clinical research to get involved in the logistics of a study, learning from colleagues responsible for its practical conduct (clinical research associates, data managers, etc.) and to take part, in person, in the practical implementation of a trial before attempting to design a study protocol.

The book ends with a brief description of the drug development process and to the phases of clinical development.

Due to their unparalleled effectiveness and efficiency, polyfluorinated chemicals (PFC") "have become essential in numerous technical applications. However, many PFCs brought to market show limited biodegradability, and their environmental persistence combined with toxic and bioaccumulative potential have become a matter of concern in some instances. This volume highlights the synthesis of PFCs, focusing on substances with improved application and environmental properties, which are a challenge for synthetic chemists. Further, modern mass spectrometric techniques for the detection and identification of biotransformation products of PFCs are described. The sorption and leaching behavior of PFC in soil is also addressed in order to predict their fate in the environment. Several contributions discuss the monitoring of PFCs in European surface, ground and drinking waters, treatment options for PFC removal from drinking water, occurrence in food, and the human biomonitoring of PFCs.

This book chiefly focuses on environmental flow, water pollution and water quality. Several chapters also cover water treatment technologies and management. In today's context, climate change and climate variability are important issues in the water sector, which is called upon to develop adaptation strategies to cope with their negative impacts. Human health depends upon the quality of water used for drinking and irrigation purposes. These core issues are discussed and addressed in several chapters. The book explores the impact of climate change on water resources and considers various climatological scenarios. In this regard, it carries out a trend analysis and compares the performance of various Global Climate Models (GCMs). Further, it conducts a water quality analysis and water quality mapping so as to provide information on the most vulnerable areas in the context of water quality. Emerging pollutants, generated from paper mills, are identified in order to choose an appropriate treatment technology. Bioremediation techniques are included for the characterization of improved water quality parameters. The book also presents a low-cost treatment technology for fluoride removal, which can help water managers ensure potable water to stakeholders. In terms of maintaining river ecology in the downstream areas of water resources project sites, the book provides a number of case studies on assessment of environmental flows. Advanced treatment technologies that can be highly advantageous for removing water pollutants are presented. Given its scope, the book offers a valuable resource for academics, water resources practitioners, scientists, water managers, environmentalists, administrators, NGOs, researchers and students who are involved in water management with a main focus on water pollution, the environment, climate change and health.

This third edition is expanded, revised and largely re-written. However the aim remains the same and it is hoped that anyone involved in Travel or Tropical Medicine will find the contents interesting, stimulating and helpful.

As before it is divided into easy-to-read sections with clear answers that sometimes encapsulate whole diseases.

The four-part question format is retained in order to aid those intending to take Certificate or other exams in Travel Medicine. The correct answer to each question is that which is generally accepted as the best one. Nonetheless the reader may quibble with some answers and the author is always happy to accept sound advice and change accordingly.

Travel Medicine has a broad canvas. It cuts across the boundaries of Infectious Diseases, Internal Medicine, Tropical Medicine, Geographical Medicine, Aviation and Refugee Medicine. Because of this the few Textbooks we have Travel Medicine are large and difficult to digest.

This little book attempts to set down in concise form the essential elements of Travel Medicine in a way that is easy to read yet challenging.

These pages certainly invite the reader to share in excitement and wonder of this fascinating subject.