Featuring the work of several world authorities, this volume places primary emphasis on the mechanism of parasite produced changes in the immune response (i.e. immunosuppression). The text covers parasitic diseases on which the World Health Organization has aggressively promoted research through its Program on Research and Training In Tropical Diseases. Chapters cover parasitic diseases such as malaria, American trypanosomiasis (Chagas' disease), African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and onchocerciasis. Also included are discussions of toxoplasmosis and amebiasis. The material is drawn from the body of literature that has been rapidly accumulating for the last 15 years. An important feature of this text is that the contributors first outline existing knowledge about the immunology of each infection, thereby enabling the reader to more easily appreciate why and how the immunological alterations that accompany a disease are important, and then, to review the postulated mechanisms for such alterations. Consequently, the impact that each parasitic infection has on the immune system is always described in the "heart" of each chapter rather than at the beginning.

The eighth edition of this popular handbook provides a thorough and completely updated overview of the occupational safety and health field and the issues safety professionals face today, and does so in an accessible and engaging manner. An excellent introductory reference for both students and professionals, Fundamentals of Occupational Safety and Health provides practical information on technology, management, and regulatory compliance issues, covering crucial topics like organizing, staffing, directing, and evaluating occupational safety programs and procedures. All major occupational safety and health topics are addressed in this comprehensive volume, including safety-related laws and regulations, hazardous materials, workplace violence, the threat of terrorism, and OSHA's recordkeeping standard. The book includes a handy directory of resources such as safety and health associations, First Responder organizations, and state and federal agencies. The eighth edition of this go-to reference work provides an easily comprehensible and well-organized format, giving readers a wealth of occupational safety and health information right at their fingertips.

This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy. The authors explore the medicinal chemistry efforts that gave rise to currently launched drugs and new anti-HIV agents, and they also highlight the latest vaccine and drug developments in the clinical management of the Ebola Virus Disease, ignited by the 2014-2016 outbreak. This work has an interdisciplinary appeal and will engage scholars and professionals in the burden of communicable diseases.

This book is an overview of the hazards of firefighting, the health risks of exposure to combustion products that characterize firefighting, the science behind interpreting these risks for purposes of identifying diseases as work-related, and the legal and policy implications of adopting legislated "presumption" for purposes of compensation. The emphasis of the book will be on the risk of cancer, cardiovascular disease, traumatic hazards, and disabling psychosocial adjustment following major incidents. Several new studies have appeared recently, including the largest study of firefighters ever done, by the National Institute of Occupational Health and Safety (NIOSH). They evidence supports the conclusion that firefighters face significant occupational health risks in addition to the obviously severe safety hazards.

This volume of the Neglected Tropical Diseases (NTD) series covers the most prevalent NTDs in Europe and Central Asia. This book discusses in detail the pathology, diagnostics and control approaches of the most important neglected pathogens occurring in these geographical regions. Each chapter focuses on one specific disease or group of related diseases, and provides the reader with in-depth insights into the topic. This volume addresses researchers in Microbiology and Biomedicine as well as clinicians and public health officials working in affected regions.

Latest Edition: Textbook of Occupational Medicine Practice (4th Edition)This book provides a link between occupational health and clinical practice. It aims to provide a valuable starting point for health professionals with an interest in occupational medicine as well as those intending to specialize in occupational medicine. It will also serve as a useful guide for all those who are interested in occupational medical practice. These include medical students at various levels, occupational health nurses, general practitioners, or colleagues and professionals in occupational health and safety - in other words, for all who have committed themselves to do the best practice for the health of working people.This third edition of the textbook has been fully revised and includes new materials and chapters. The contents of the book have been streamlined to appear in two sections. The approach of examining occupational health issues and concerns from the standpoint of clinical presentations of the different organ systems is retained. These clinically oriented chapters form Section One. Section Two comprises issues of special interest to occupational health practitioners such as screening and routine medical examinations, assessment of disability for compensation, medical planning and management of industrial disasters, occupational medicine practice and the law, and the prevention of occupational diseases.Several changes have directly resulted from feedback from readers of the previous editions. Among these are the inclusion of new chapters on occupational infections, metabolic disorders, and occupational medicine practice and the law. As before, case studies have been incorporated in the chapters to make clear the relevant issues.

Exposure to ambient air pollutants, both indoors and outdoors has been associated with the exacerbation and also in the etiology of diverse human diseases. This book offers an overview of our current understanding of air pollution health risks and how this knowledge is being used in the regulatory, therapeutic intervention measures to protect the public health and reduce the disease burden caused by acute and long-term exposure to air pollutants. Air Pollution and Health Effects provides readers with a comprehensive understanding of air pollution health risks, morbidity and the global disease burden, whilst also delivering critical review on state of the art research so as to gain a fundamental understanding of the biological mechanisms involved in the etiology of air pollution-induced diseases. Chapters range from pregnancy outcomes and pre-term birth, carcinogens in the ambient aerosol and the health consequences of indoor biomass burning. Special emphasis is placed on regional and local air pollution and its impact on global health along with suitable preventive and interventional measures. With contributions from international experts in the field this volume is a valuable guide for researchers and clinicians in toxicology, medicine and public health as well as industry and government regulatory scientists involved in health protection.

This book provides an overview to researchers, graduate, and undergraduate students, as well as academicians who are interested in arsenic. It covers human health risks and established cases of human ailments and sheds light on prospective control measures, both biological and physico-chemical. Arsenic (As) is a widely distributed element in the environment having no known useful physiological function in plants or animals. Historically, this metalloid has been known to be used widely as a poison. Effects of arsenic have come to light in the past few decades due to its increasing contamination in several parts of world, with the worst situation being in Bangladesh and West Bengal, India. The worrying issue is the ingestion of arsenic through water and food and associated health risks due to its carcinogenic and neurotoxic nature. The impact of the problem is widespread, and it has led to extensive research on finding both the causes and solutions. These attempts have allowed us to understand the various probable causes of arsenic contamination in the environment, and at the same time, have provided a number of possible solutions. It is reported that more than 200 mineral species contain As. Generally, As binds with iron and sulfur to form arsenopyrite. According to one estimate from the World Health Organization (WHO), contextual levels of As in soil ranges from 1 to 40 mg kg-1. Arsenic toxicity is related to its oxidation state which is present in the medium. As is a protoplastic toxin, due to its consequence on sulphydryl group it interferes in cell enzymes, cell respiration and in mitosis. Exposure of As may occur to humans via several industries, such as refining or smelting of metal ores, microelectronics, wood preservation, battery manufacturing, and also to those who work in power plants that burn arsenic-rich coal.

This book brings together the most current thinking and research on educator stress and how education systems can support quality teachers and quality education. It adopts an occupational health perspective to examine the problem of educator stress and presents theory-driven intervention strategies to reduce stress load and support educator resilience and healthy school organizations. The book provides an international perspective on key challenges facing educators such as teacher stress, teacher retention, training effective teachers, teacher accountability, cyber-bullying in schools, and developing healthy school systems. Divided into four parts, the book starts out by introducing and defining the problem of educator stress internationally and examining educator stress in the context of school, education system, and education policy factors. Part I includes chapters on educator mental health and well-being, stress-related biological vulnerabilities, the relation of stress to teaching self-efficacy, turnover in charter schools, and the role of culture in educator stress. Part II reviews the main conceptual models that explain educator stress while applying an occupational health framework to education contexts which stresses the role of organizational factors, including work organization and work practices. It ends with a proposal of a dynamic integrative theory of educator stress, which highlights the changing nature of educator stress with time and context. Part III starts with the definition of what constitute healthy school organizations as a backdrop to the following chapters which review the application of occupational health psychology theories and intervention approaches to reducing educator stress, promoting teacher resources and developing healthy school systems. Chapters include interventions at the individual, individual-organizational interface and organizational levels. Part III ends with a chapter addressing cyber-bullying, a new challenge affecting schools and teachers. Part IV discusses the implications for research, practice and policy in education, including teacher training and development. In addition, it presents a review of methodological issues facing researchers on educator stress and identifies future trends for research on this topic, including the use of ecological momentary assessment in educator stress research. The editors' concluding comments reflect upon the application of an occupational health perspective to advance research, practice and policy directed at reducing stress in educators, and promoting teacher and school well-being.

This is the first book to summarize all aspects of allergenic pollen: production, atmospheric distribution, and health impacts, as well as the means of monitoring and forecasting these phenomena. Based on a four-year effort by a large group of leading European scientists, this book highlights the new developments in research on allergenic pollen, including the modelling prospects and effects of climate change. The multidisciplinary team of authors offers insights into the latest technology of detection of pollen and its allergenic properties, forecasting methods, and the influence of allergenic pollen on the population. The comprehensive coverage in this book makes it an indispensible volume for anyone dealing with allergenic pollen worldwide. Readers involved in environmental health, aerobiology, medicine, and plant science will find this book of interest.

Environmental professionals can no longer simply publish research in technical journals. Informing the public is now a critical part of the job. Environmental Communication demonstrates, step by step, how it's done, and is an essential guide for communicating complex information to groups not familiar with scientific material. It addresses the entire communications process, from message planning, audience analysis and media relations to public speaking - skills a good communicator must master for effective public dialogue. Environmental Communication provides all the knowledge and tools you need to reach your target audience in a persuasive and highly professional manner.

"This book will certainly help produce the skills for environmental communications sorely needed for industry, government and non-profit groups as well as an informed public." Sol P. Baltimore, Director, Environmental Communications and Adjunct faculty, Hazardous Waste management program, Department of Chemical Engineering, College of Engineering, Wayne State University, Detroit, Michigan.

"All environmental education professionals agree that the practice of good communications is essential for the success of any program. This book provides practical skills for this concern." Ju Chou, Associate Professor, Graduate Institute of Environmental Education National Taiwan Normal University Taipei, Taiwan

This book includes a collection of chapters illustrating the application of geochemical methods to investigate the interactions between geological materials and fluids with humans. Examples include the incorporation and human health effects of inhaling lithogenic materials, the reactivity of biological fluids with geological materials, and the impact on nascent biomineral formation. Biomineralization is investigated in terms of mineralogy, morphology, bone chemistry, and pathological significance with a focus on the health impacts of "foreign" geological/environmental trace element incorporation. One of the contribution is devoted to particulate matter, the presence of metals and metalloids in the environment, and the possibility of using human hair as a biomarker between environmental/geological exposure and human bioincorporation. Other chapters focus on the last advances on the analytical methods and instrumentational approaches to investigating the chemistry of biological fluids and tissues.

This book chiefly focuses on environmental flow, water pollution and water quality. Several chapters also cover water treatment technologies and management. In today's context, climate change and climate variability are important issues in the water sector, which is called upon to develop adaptation strategies to cope with their negative impacts. Human health depends upon the quality of water used for drinking and irrigation purposes. These core issues are discussed and addressed in several chapters. The book explores the impact of climate change on water resources and considers various climatological scenarios. In this regard, it carries out a trend analysis and compares the performance of various Global Climate Models (GCMs). Further, it conducts a water quality analysis and water quality mapping so as to provide information on the most vulnerable areas in the context of water quality. Emerging pollutants, generated from paper mills, are identified in order to choose an appropriate treatment technology. Bioremediation techniques are included for the characterization of improved water quality parameters. The book also presents a low-cost treatment technology for fluoride removal, which can help water managers ensure potable water to stakeholders. In terms of maintaining river ecology in the downstream areas of water resources project sites, the book provides a number of case studies on assessment of environmental flows. Advanced treatment technologies that can be highly advantageous for removing water pollutants are presented. Given its scope, the book offers a valuable resource for academics, water resources practitioners, scientists, water managers, environmentalists, administrators, NGOs, researchers and students who are involved in water management with a main focus on water pollution, the environment, climate change and health.

This book offers an extensive look into the ways living through the COVID-19 pandemic has deepened our understanding of the crises people experience in their relationships with work. Leading experts explore burnout as an occupational phenomenon that arises through mismatches between workplace and individuals on the day-to-day patterns in work life. By disrupting where, when, and how people worked, pandemic measures upset the delicate balances in place regarding core areas of work life. Chapters examine the profound implications of social distancing on the quality and frequency of social encounters among colleagues, with management, and with clientele. The book covers a variety of occupational groups such as those in the healthcare and education sectors, and demonstrates the advantages and strains that come with working from home. The authors also consider the broader social context of working through the pandemic regarding risks and rewards for essential workers. By focusing on changes in organisational structures, policies, and practices, this book looks at effective ways forward in both recovering from this pandemic and preparing for further workplace disruptions. A wide audience of students and researchers in psychology, management, business, healthcare, and social sciences, as well as policy makers in government and professional organisations, will benefit from this detailed insight into the ways COVID-19 has affected contemporary work attitudes and practices.

Due to their unparalleled effectiveness and efficiency, polyfluorinated chemicals (PFC") "have become essential in numerous technical applications. However, many PFCs brought to market show limited biodegradability, and their environmental persistence combined with toxic and bioaccumulative potential have become a matter of concern in some instances. This volume highlights the synthesis of PFCs, focusing on substances with improved application and environmental properties, which are a challenge for synthetic chemists. Further, modern mass spectrometric techniques for the detection and identification of biotransformation products of PFCs are described. The sorption and leaching behavior of PFC in soil is also addressed in order to predict their fate in the environment. Several contributions discuss the monitoring of PFCs in European surface, ground and drinking waters, treatment options for PFC removal from drinking water, occurrence in food, and the human biomonitoring of PFCs.

In recent years many introductory textbooks on clinical trial methodology have been published, some of which are excellent, in addition to a very extensive specialist literature. Nevertheless, here is a new book on methods and issues in clinical research. The objectives can be summarized in three points. 1. Integrate medical and statistical components of clinical research. 2. Do justice to the operational and practical requirements of clinical research. 3. Give space to the ethical implications of methodological issues in clinical research.

The scope of clinical research is to evaluate the effect of a treatment on the evolution of a disease in the human species. The treatment can be pharmacological, surgical, psychological/behavioral or organizational/logistic. The disease, intended as an impairment of a state of well-being or a condition capable of provoking such impairment over time, can be universally accepted as such (e.g. a cancer or a bone fracture) or perceived as such only by limited groups of individuals in a given cultural context (e.g. hair loss or weight gain). The course of the disease that ones wishes to change can be the one with no intervention or, more frequently, the one observed with the available treatment. The evaluation of the effect of a treatment on the course of a disease is a lengthy process, which progresses in increasingly complex stages.

A detailed coverage of the logistic, administrative and legal aspects of clinical research is outside the scope of this book. However, throughout the book we keep reminding the reader of these aspects because, as already mentioned, we firmly believe they have a crucial role in determining the success of a study. The history of clinical research is paved with relics of studies started with great pomp, riding great ideas and great hopes, which drowned miserably because of inadequate logistical preparation. In our experience, the excessive complexity of a clinical trial is the single most frequent cause of failure: the study is perfect on paper, but impossible to implement by patients and staff alike. The distance between the principal investigators and the reality of clinical research in its day-to-day practice is often the main cause of such disasters. We warmly encourage everyone involved in clinical research to get involved in the logistics of a study, learning from colleagues responsible for its practical conduct (clinical research associates, data managers, etc.) and to take part, in person, in the practical implementation of a trial before attempting to design a study protocol.

The book ends with a brief description of the drug development process and to the phases of clinical development.

This book shows the advantages of using different perspectives and scientific backgrounds for developing support technologies that are integrated into daily life. It highlights the interaction between people and technology as a key factor for achieving this integration and discusses relevant methods, concepts, technologies, and applications suitable for interdisciplinary exchange and collaboration. The relationship between humans and technology has become much more inclusive and interdependent. This generates a number of technical, ethical, social, and practical issues. By gathering contributions from scholars from heterogeneous research fields, such as biomechanics, various branches of engineering, the social sciences, information science, psychology, and philosophy, this book is intended to provide answers to the main questions arising when support technologies such as assistance systems, wearable devices, augmented reality, and/or robot-based systems are constructed, implemented, interfaced and/or evaluated across different application contexts.

Adds three new chapters (constructed wetlands, stream sediments, and rice production systems) and is updated throughout Examines the adaptation of wetland plants to varying anaerobic soil conditions Provides the basic concepts involved in biogeochemical cycling of nutrients and contaminants in wetlands as related to environmental significance and ecological functions Examines the role of microbial processes in sulfate reduction, denitrification, and methane production Provides case studies for key biogeochemical processes governing wetland function in freshwater wetlands

This book explores the challenges that confront leaders in government and industry when making decisions in the areas of environmental health and safety. Today, decision making demands transparency, robustness, and resiliency. However thoughtfully they are devised, decisions made by governments and enterprises can often trigger immediate, passionate public response. Expertise Under Scrutiny shows how leaders can establish organizational decision making processes that yield valid, workable choices even in fast-changing and uncertain conditions. The first part of the book examines the organizational decision making process, describing the often-contentious environment in which important environmental health and safety decisions are made, and received. The authors review the roles of actors and experts in the decision making process. The book goes on to address such topics as: * The roles of actors and experts in the decision making process * Ethics and analytics as drivers of good decisions * Why managing problems in safety, security, environment, and health Part II offers an outline for adopting a formal decision support structure, including the use of decision support tools. It includes a chapter devoted to ELECTRE (ELimination and Choice Expressing Reality), a multi-criteria decision analysis system. The book concludes with an insightful appraisal and analysis of the expertise, structure and resources needed for navigating well-supported, risk-informed decisions in our 21st Century world. Expertise Under Scrutiny benefits a broad audience of students, academics, researchers, and working professionals in management and related disciplines, especially in the field of environmental health and safety.

This book provides a concise, yet comprehensive overview of the many facets relating to human health risk assessments in relation to chemical exposure problems. It presents some very important tools and methodologies that can be used to address chemical exposure and public health risk management problems in a consistent, efficient, and cost-effective manner. On the whole, the book represents a collection and synthesis of the principal elements of the risk assessment process that may be used to more effectively address issues pertaining to human exposures to chemicals found in modern societies. This also includes an elaboration of pertinent risk assessment concepts and techniques/methodologies for performing human health risk assessments. Written for both the novice and the experienced, the subject matter of this book is an attempt at offering a simplified and systematic presentation of public health risk assessment methods and application tools - all these facilitated by a layout that will carefully navigate the user through the major processes involved. A number of illustrative example problems are interspersed throughout the book, in order to help present the book in an easy-to-follow, pragmatic manner.

Polluted air and contaminated food and water are major causes of human health deterioration, but public health policy has long struggled to effectively address these concerns. This timely book--written for a wide audience of policy makers, researchers, and general readers--synthesizes what we already know about environmental hazards, identifies the gaps in our knowledge, and provides a roadmap for reducing human exposure to environmental pollution. With contributions from leading experts, Environmental Determinants of Human Health examines numerous pollutants, both inorganic and organic, in the context of their human health impacts. Individual chapters explore exposure pathways, macroeconomic impacts of human health deterioration, technological and non-technological methods for reducing exposures, monetary and non-monetary benefits from exposure reduction, and risk communication and awareness, including citizen participation approaches. This volume is a crucial text for policy makers requiring scientific justification for the development of new environmental regulations, scientists researching public health and environmental contamination, and members of the public interested in human health issues.

Mit dem Anstieg der Lebenserwartung in Europa geht ein Wandel der Erwerbs- und Lebensverlaufe einher, die durch Bruche und Wechsel der beruflichen Tatigkeiten gepragt sind. Ein zentrales Anliegen ist daher, jedem die Teilhabe am Erwerbsleben uber den gesamten Lebensverlauf zu ermoeglichen und zugleich soziale Rechte durch angemessenen sozialen Schutz zu gewahrleisten. Mit juristischen, sozialpolitischen und empirischen Analysen widmet sich dieses Buch dem Zusammenspiel verschiedener Sozialschutzmechanismen und ihren Schwierigkeiten, sich den neuen Entwicklungen anzupassen. Es prasentiert die Impulse europaischer Instanzen und die Antworten verschiedener europaischer Staaten auf die Herausforderung, Flexibilisierung der Beschaftigung und Modernisierung der Sozialschutzsysteme in Einklang zu bringen. Increasing life expectancy in Europe entails a remodelling of career development and life course, marked by discontinuities and changing professional activities. One of the concerns is ensuring that everybody may participate in gainful activities during his or her life course while also guaranteeing social rights through adequate social protection. By means of legal, socio-political and empirical analyses this book embarks on the interrelationship of different social protection mechanisms and the resulting difficulties of adapting to these new employment patterns. It presents European impulses and the reactions of several European states to the challenge of reconciling flexibility of employment and modernisation of social protection. L'augmentation de l'esperance de vie en Europe suscite un changement des modes de parcours professionnels et de vie constitues de ruptures et de conversions d'activite. L'une des preoccupations est de permettre a chacun de poursuivre une activite professionnelle tout au long de sa vie tout en pouvant beneficier d'une protection sociale adaptee. A travers des analyses juridiques, socio-politiques et empiriques, cet ouvrage aborde les interferences et les difficultes d'adaptation des mecanismes de protection sociale aux nouvelles evolutions. Il presente les impulsions europeennes et les choix effectues au niveau national pour concilier flexibilite de l'emploi et modernisation des systemes de protection sociale.

This volume highlights some of the challenges in delivering effective environmental health interventions, and presents examples of emergent theories and case studies that can help close the gap between intent and impact. These include impact crediting systems, objective evidence gathering tools, and social businesses that service environmental health. The case studies presented cross disciplines, scales, organizational and national boundaries and can defy easy categorization. A water project may be designed for a health impact, but financed with a climate change tool, and leverage high tech cell phone sensors. A cookstove program may be primarily concerned with employment and capacity building, but balance environmental and health concerns. Presently, the impact of interventions may not always be aligned to the intent sought. In this book, readers will discover alternative ways to move the mindset of funders and implementers toward pay-for-performance models of humanitarian and environmental interventions. Undergraduate and graduate students taking courses in social enterprise, social entrepreneurship, global health, appropriate technology, international development and development engineering would benefit from these increasingly non-traditional case studies that challenge commonly accepted presentations of poverty reduction and social enterprise.

This book's main objective is to decipher for the reader the main processes in the atmosphere and the quantification of air pollution effects on humans and the environment, through first principles of meteorology and modelling/measurement approaches. The understanding of the complex sequence of events, starting from the emission of air pollutants into the atmosphere to the human health effects as the final event, is necessary for the prognosis of potential risk to humans from specific chemical compounds and mixtures of them. It fills a gap in the literature by providing a solid grounding in the first principles of meteorology and air pollution, making it particularly useful for undergraduate students. Its broad scope makes it a valuable text in many related disciplines, containing a comprehensive and integrated methodology to study the first principles of air pollution, meteorology, indoor air pollution, and human exposure. Problem-solving exercises help to reinforce concepts.

In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.