This volume provides an up-to-date collection of protocols describing some of the key methods to investigate the integrated stress response (ISR), a vital evolutionarily conserved mechanism that enables eukaryotic cells to adapt to stress conditions and alter their gene expression programs. The content of the book is split between techniques to analyze mRNA translation regulation and methods to analyze interaction networks and ribonucleoprotein (RNP) granules. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Integrated Stress Response: Methods and Protocols serves as an ideal guide to help accelerate research into the complex and fascinating biology of the ISR.

The book addresses the interactions between wetlands and human health and well-being. A key feature is the linking of ecology-health and the targeting of practitioners and researchers. The environmental health problems of the 21st Century cannot be addressed by the traditional tools of ecologists or epidemiologists working in their respective disciplinary silos; this is clear from the emergence and re-emergence of public health and human well-being problems such as cholera pandemics, mosquito borne disease, and episodic events and disasters (e.g. hurricanes). To tackle these problems requires genuine cross-disciplinary collaboration; a key finding of the recently concluded Millennium Ecosystem Assessment when looking at human well-being and ecosystem health. This book brings the disciplines of ecology and health sciences closer to such a synthesis for researchers, teachers and policy makers interested in or needing information to manage wetlands and human health and well-being issues.

This book targets new advances in areas of treatment and drug delivery sciences for Malaria. This is the only published book which compiles the complete road map of malarial drug delivery systems along with an overview on the pathology, current state of malaria across the globe, new clinical trials, emerging drugs and evolving novel drug delivery platforms. A wide variety of novel micro-and nano-formulations using promising technologies are being explored to deliver the malarial drug via different administration routes. This book addresses the gap between new approaches and old treatment modalities and how the former is superior in pharmacological performance when tested in in-vitro and in-vivo. Audience from wide range group like from researchers to regulatory bodies can benefit from the compiled information to find out patient needs and addresses a much-needed update to the existing malaria drug delivery research.

In Risk Analysis of Complex and Uncertain Systems acknowledged risk authority Tony Cox shows all risk practitioners how Quantitative Risk Assessment (QRA) can be used to improve risk management decisions and policies. It develops and illustrates QRA methods for complex and uncertain biological, engineering, and social systems - systems that have behaviors that are just too complex to be modeled accurately in detail with high confidence - and shows how they can be applied to applications including assessing and managing risks from chemical carcinogens, antibiotic resistance, mad cow disease, terrorist attacks, and accidental or deliberate failures in telecommunications network infrastructure. This book was written for a broad range of practitioners, including decision risk analysts, operations researchers and management scientists, quantitative policy analysts, economists, health and safety risk assessors, engineers, and modelers.

This textbook focuses on underground ventilation, addressing both theoretical and practical aspects. Readers will develop a deeper understanding of mine ventilation and adjacent areas of research. The content is clearly structured, moving through chapters in a pedagogical way. It begins by presenting an introduction to fluid mechanics, before discussing the environmental conditions in mines, underground fire management, and international legislation concerning mines. Particular attention is paid to development ends ventilation, an area that is underrepresented in scientific research. Each chapter includes a concise theoretical summary, followed by several worked-out examples, problems and questions to develop students' skills. This textbook will be useful for undergraduate and master's degree students around the world. In addition, the large number of practical cases included make it particularly well suited to preparing for professional engineer examinations and as a guide for practising engineers.

This book presents papers from the 10th Applied Research Conference in Africa (ARCA), showcasing the latest research on education and inclusive, safe, resilient, and sustainable communities. The conference is focused on applied research discussion and its dissemination, developing understanding about the role of research and researchers in the development of the continent. Education is a key driver to transform lives, build peace, eradicate poverty and drive sustainable development in Africa. Researchers face large challenges to making a meaningful contribution to the development of Africa. It is a continent where research can at time be not viewed directly related to development. The aim of the Applied Research Conference in Africa is to provide a platform for capacity building and networking among researchers in Africa. The proceedings is focussed on applied research, its discussion and dissemination and will be if interest to researchers, professors, graduate students, policymakers and professionals in industry.

Surfactants are often completely invisible to us and yet they are present in almost every chemical that we use in our daily life. They are found in toothpastes, cosmetics, sunscreens, mayonnaise, detergents, and an array of cleaning products. Traditional surfactants are known to have adverse environmental impacts spurring research into eco-friendly and cost-effective surfactants from renewable resources. Surfactants from Renewable Raw Materials examines the class of surfactants synthesized using plant-based raw materials detailing their properties, applications, bioavailability, and biodegradability. The concluding chapter reviews patent activity over the last decade. Additional features include: Addresses the tremendous variation found in the raw materials used to synthesize commercially available surfactants. Explores the selection of raw materials based upon the desired hydrophobic group or hydrophilic group to be incorporated into the product. Examines the characteristics and medicinal applications of pulmonary surfactants in preterm babies as well as their probable contribution in COVID-19 Discusses the biodegradability of surfactants to assist with the determination of truly green surfactants. This comprehensive reference will prove indispensable for professional and academic researchers creating or working with bio-based surfactants.

This book introduces flood inundation area and flood risks assessment based on a comprehensive monitoring system using remote sensing and geographic information system technologies. Taking the 2011 flood disaster of Ayutthaya in Thailand as an example, it presents a flood intrusion zone identification method based on remote sensing technology, spatial information technology and geographic information system for flood disaster monitoring and early warning system. It introduces the study area and data, vegetation index, improved support vector machine and flood intrusion zone identification method. It also analyzes the flood remote sensing parameters and waterborne diseases, method of risk assessment of waterborne disease outbreak, waterborne disease outbreak risk monitoring based on backpropagation neural network and its expert system. It not only promotes a new interdisciplinary approach both in public health and space information technology, but also greatly supports decision makers in disaster reduction.

Allergy is an immunological disease caused by multiple factors and characterized by variability, specificity and complexity. "Multidisciplinary Approaches to Allergies" covers diverse aspects ranging from basic molecular mechanisms to societal issues within the framework of multidisciplinary approaches to allergies. It contains 29 chapters in 6 parts: General Allergy; Allergenic Sources and Allergens; Diagnosis; Therapies and Pharmacy; Hypoallergenic Products; Environment, Hygiene and Societal Issues. It can be used in education and research as introductory and supplementary material. It is also an indispensable tool for scientists and doctors who are searching for an integrated way for allergy prevention, treatment and management.

Zhong-Shan Gao, Ph.D., is Professor of Fruit Science and Allergy at the Department of Horticulture and the Allergy Research Center, Zhejiang University, China. Hua-Hao Shen, M.D., Ph.D., is Professor of Respiratory Diseases at the Second Affiliated Hospital, School of Medicine, Zhejiang University, China, and Professor in the Chang Jiang Scholars Program (MOE). Min Zheng, M.D., Ph.D., is Professor of Dermatology at the Second Affiliated Hospital, School of Medicine, Zhejiang University, China. Lynn J. Frewer, Ph.D., is Professor of Food & Society at the School of Agriculture, Food and Rural Development, Newcastle University, UK. Luud J.W.J. Gilissen, Ph.D., is senior researcher at Plant Research International, Wageningen University and Research Centre, the Netherlands.

In 1976, areas of the great mountain regions remained unknown and acute mountain sickness was a medical mystery waiting to be explored. Into this arena stepped the Birmingham Medical Research Expeditionary Society. It was formed by a group of young doctors at the Queen Elizabeth Hospital, Birmingham, and its members were looking for excitement. They were inquisitive, energetic and fearless. Having gathered ideas and borrowed some medical equipment, they took a plane to Kathmandu. From there they trekked to the north side of Annapurna, exploring and testing the effects of low oxygen levels on their bodies and minds. there has been a further twelve expeditions since, all investigating the effects of low oxygen on the human body. This book is a recollection of those expeditions.

Presents current research in AOP techniques along with hybrid technologies Covers latest advances in technological know-how for remediation of wastewater soiled with micropollutants Discusses pressing environmental pollution issues associated with AOPs needed for wastewater remediation Presents future perspective as well as techno-economic analysis in implementing various AOPs Reviews strategies to limit the micropollutants in water bodies

The subject of medical entomology contin- factors such as insecticide susceptibility, vec- ues to be of great importance. Arthropodborne tor competence, host preference and similar im- diseases such as malaria, yellow fever, dengue portant phenomena. Now, a variety of new and filariasis continue to cause considerable methods are available to study genes, and to human suffering and death. Problems in ani- genetically alter important characteristics in mal production, wildlife and pets of humans vectors as a potential means of controlling hu- caused by arthropods still exact a large eco- man and animal diseases. nomic toll. In the past 2 decades, the invasion Many of the traditional tasks of medical en- of exotic pests and pathogens has presented tomologists continue to be important. Arthro- new problems in several countries, including pod systematics is important because the need the USA. For example, the year 1999 saw the for accurate identification of arthropods is vital invasion of the eastern USA by Aedes japonicus, to an understanding of natural disease cycles. an Asian mosquito, and West Nile virus, a mos- Systematics has been made even more challeng- quito-transmitted African arbovirus related to ing because of the current appreciation of the St. Louis encephalitis virus. number of groups of sibling species among vec- At the same time old and new health prob- tors of important disease pathogens. New mo- lems with arthropods occur, the traditional ap- lecular tools are assisting in separating these proaches to arthropod control have become forms.

Over the last few decades, unprecedented global population growth has led to increased demand for food and shelter. At the same time, extraction of natural resources beyond the Earth's resilience capacity has had a devastating effect on ecosystems and environmental health. Furthermore, climate change is having a significant impact in a number of areas, including the global hydrological cycle, ecosystem functioning, coastal vulnerability, forest ecology, food security, and agricultural sustainability. According to the Intergovernmental Panel on Climate Change (IPCC), only immediate and sustained action will prevent climate change causing irreversible and potentially catastrophic damage to our environment. This book presents various scientific views and concepts, research, reviews, and case studies on contemporary environmental issues in changing climate scenarios and highlights different adaptation measures. Increasing awareness of modern-day patterns of climate change, it addresses questions often raised by environmental scientists, researchers, policymakers and general readers.

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

This book gathers cutting-edge research and best practices relating to occupational risk and safety management, healthcare and ergonomics. It covers strategies for different industries, such as construction, chemical and healthcare. It emphasises challenges posed by automation, discusses solutions offered by technologies, and reports on case studies carried out in different countries. Chapters are based on selected contributions to the 18th International Symposium on Occupational Safety and Hygiene (SHO 2022), held on September 8-9, 2022, in Porto, Portugal. By reporting on different perspectives, such as the ones from managers, workers and OSH professionals, and covering timely issues, such as implications of telework ,issues related to gender inequality and applications of machine learning techniques in occupational health, this book offers extensive information and a source of inspiration to OSH researchers, practitioners and organizations operating in both local and global contexts.

This book provides a complete practical guide of processing data in public health with R language. On the basis of the author’s research and teaching experiences, this book serves either as a textbook for undergraduates and graduates in public health or as a tutorial for self-learning. Many first-hand examples are presented with source data, R scripts, and graphs, as well as detailed explanations, which could be easily reproduced by readers so as to better understand the data processing principles and procedures. Popular and novel R packages in public health are introduced as well.

This book provides occupational health (OH) professionals with a theoretical basis for addressing the ethical issues that they confront in their practice. There is often a lack of in-depth moral analysis of the issues that OH practitioners face on a daily basis. The ICOH Code of Ethics sets out the important principles that guide OH practice. This book builds on these core principles, starting from an application of moral theories in the OH context and illustrating how ethical conflicts could be resolved, by carrying out ethical analyses of several case studies. In this way, it aims to link ethical theory to OH practice.

Agriculture is one of the oldest and most global human enterprises, and as the world struggles with sustainable practices and policies, agricultural chemistry has a clear role to play. This book highlights the ways in which science in agriculture is helping to achieve global sustainability in the 21st century, and demonstrates that this science can and should be a leading contributor in discussion on environmental science and chemistry. The four drivers of this subject are presented, those being economic, environmental, regulatory and scientific, and help showcase agricultural chemistry as a dynamic subject that is contributing to this necessity of global sustainability in the 21st century.

The 'Advances in Plant Biopesticides' comprises 19 chapters on different important issues of developing biopesticides from promising botanicals and its phytomolecules based on the research reviews in the area concern. The book is written by reputed scientists and professors of both developed and developing countries namely Australia, Canada, Czech Republic, Egypt, Greece, India, Kenya, Thailand, Turkey, United Kingdom, and USA represented by almost 53 contributors. The book is organized and presented in such a form that the readers can acquire and enhance their knowledge in plant biopesticide bioresources, its application in different areas to manage pests and diseases of field crops, stored products with status of exploring in Africa, non-target effects on beneficial arthropods, control of arthropods of veterinary and vectors of communicable diseases, efficacy in controlling honeybee mite pests, prospect of applying new tools to enhance the efficacy of plant biopesticides through use of nanotechnology, most important plant derived active principle as source of biopesticides, possible mode of action of phytochemicals against arthropods, limitation, production status, consumption, formulation, registration and quality regulation of plant biopesticides and have been cited by important scientific references. Most importantly, the book also highlights a unique example for developing biopesticides based on the research on Annonaceae as potential source of plant biopesticide, exploiting phytochemicals for developing green technology for sustainable crop protection strategies to withstand climate change with example in Africa, and overview in developing insect resistance to plant biopesticides. Most of the chapter contributing authors are internationally reputed researchers and possess experiences of more than three to four decades in the area of plant biopesticides. The contributing and corresponding authors of the book - Advances in Plant Biopesticides proposed and identified by the editor (Dwijendra Singh) include distinguished professors and reputed scientists from different continents of the world namely MB Isman (Canada), Nadia Z Dimetry (Egypt), Zeaur R Khan (Kenya), John A Pickett (UK), Gadi VP Reddy (USA), S Gopalakrishnan (India), Anand Prakash (India), Chirantan Chattopadyay (India), Christos G Athanassiou (Greece), Philip C. Stevenson (UK), S Raguraman (India), S Ghosh (India), Mir S Mulla (USA), Apiwat Tawatsin (Thailand), Dwijendra Singh (India), K Sahayaraj (India), Suresh Walia (India), T Shivanandappa (India), Roman Pavela (Czeck Republic), Errol Hasan (Australia), Ayhan Gokce (Turkey), SK Raza (India), and their colleague co-contributors. This book would certainly provide the updated knowledge to global readers on plant biopesticides as one of the important reference source and would stimulate to present and future researchers, scientists, student, teachers, entrepreneurs, and government & non-government policy makers interested to develop new & novel environmentally safe plant biopesticides world over.

Water is the driving force of all nature. This old quote from Leonardo da Vinci reminds us that without water life is simply not possible. As a consequence, water is probably the most important wealth for humanity. In spite of this, drinking water is still polluted by man-made toxicals gathered by waters in soils and the atmosphere. This book presents advanced methods to clean water and air. Chapters also focus on biofuels, greenhouse gases and genetically modified crops.

Presents an overview of current and developing treatment technologies for water polluted with emerging pollutants Gives in-depth account and analysis of advanced materials and methods for separation and treatment Reviews analytical techniques applied to detect emerging pollutants Discusses overall effect of policies on current chemicals/plastics/APIs in the market Includes pertinent case studies and regulations

One of the fundamental principles of green chemistry is to design chemical products that minimize adverse consequences to human health and the environment. While chemists have been designing molecules for 200 years to have a limitless range of commercial applications, little or no attention has been given to developing commercial chemicals while avoiding hazards and toxicity. This book is the first to provide chemists with useful, practical guidance on how to minimize or avoid a wide range of hazards. Building on the insights gained from the pharmaceutical industry over the past 25 years on how to create desirable biological effects, the authors demonstrate how to avoid undesirable biological effects by design.

In the current economy, companies are expected to turn on a dime in response to changing market needs to stay vibrant. What that means is that companies are constantly reorganizing. Employees are living in a constant state of change. This dynamic in the workplace has affected worker satisfaction, morale, and burnout. This is the first treatment manual to focus on treating job-related issues, whether it's conflict in the workplace, stress, burnout, performance, and more. Divided into two parts, Part One sets the stage with a discussion of the economic climate and how it impacts businesses, how business reacts to it, and how the new business climate affects employees. Part Two lays out the most current research on effectively treating work-related client issues. Individual, group, and organizational interventions are included, along with case examples, practical treatment exercises, checklists, and outlines for treatment.
Summarizes how the changing workplace impacts workersCovers effective ways of treating and preventing worker problemsIncludes case examples of treating common workplace depression, accidents, substance abuse, violence, stress, illness, conflict, and performanceDiscusses individual, group, and organizational interventionsProvides online exercises, checklists, evaluation formats, and outlines for treatmentIntegrates issues of diversity including race, ethnicity, age, and gender

This book offers a survey of the state of the art in the field of motion sickness. It begins by describing the historical background and the current definition of motion sickness, then discusses the prevalence among individuals, along with the physiological and psychological concomitants of the disorder. It reviews the incidence of motion sickness in numerous provocative motion environments and discusses various personal factors that appear to influence this aspect. Various characteristics of provocative motion stimuli are also described, together with the results of studies conducted in the laboratory, on motion simulators and at sea. Laboratory tests that could potentially be used to assess an individual's susceptibility to motion sickness and his or her ability to adapt to motion environments are presented in detail, together with the ways in which individuals might be trained to prevent motion sickness or more effectively cope with motion environments. In closing, the book reports on the cognitive-behavioral approach developed by the author (Dobie, 1963) as well as the various desensitization programs employed in military settings, and discusses the relative effectiveness of these methods in comparison to cognitive-behavioral counseling.