Homeostasis. The health of an organism is influenced by external
and internal changes that may lead to the loss of homeostasis.
Under healthy conditions organisms compensate these changes. If
compensation fails disease ensues. Attention will be paid to
lifestyle, environmental changes, genetic makeup and health system.
It willbe answered how lifestyle, environment, genetic makeup and
social conditions help to maintain or upset the biological balance
and lead to cancer.
Tumor formation. To understand this process the transfer of
intracellular and the pathways of extracellular information (signal
transduction) will be reviewed briefly. Loss of cellular balance
may lead to cell death (.e.g. apoptosis) or to rapid cell growth of
cells leading to tumor formation.
Metastasis. Animal tumor models serve to understand the spread of
the primary tumor cells to distant locations of the organism.
Different types of tumors and metastases will be reviewed. "
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