Forensic DNA Profiling Protocols (Hardcover, 1998 ed.)

It is now more than ten years since Dr. Alec Jeffreys (now Professor Sir Alec Jeffreys, FRS) reported in Nature that the investigation of certain minisatellite regions in the human genome could produce what he termed DNA fingerprints and provide useful information in the fields of paternity testing and forensic analysis. Since that time we have witnessed a revolution in the field of forensic identification. A total change of technology, from serological or electrophoretic analysis of protein polymorphisms to direct investigation of the underlying DNA polymorphisms has occurred in a short space of time. In addition, the evolution and development of the DNA systems themselves has been rapid and spectacular. In the last decade we have progressed from the multilocus DNA fing- prints, through single locus systems based on the same Southern blot RFLP technology, to a host of systems based on the PCR technique. These include Allele Specific Oligonucleotide (ASO)-primed systems detected by dot blots, the "binary" genotypes produced by mapping variations within VNTR repeats demonstrated by minisatellite variant repeat (MVR) analysis, and yet other fragment-length polymorphisms in the form of Short Tandem Repeat (STR) loci. Hand in hand with the increasing range of systems available has been the development of new instrumentation to facilitate their analysis and allow us to explore the possibilities of high volume testing in the form of mass scre- ing and offender databases.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 98
Release date:	1998
First published:	1998
Editors:	Patrick J. Lincoln
Dimensions:	235 x 155 x 19mm (L x W x T)
Format:	Hardcover
Pages:	309
Edition:	1998 ed.
ISBN-13:	978-0-89603-443-3
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy > Cytology Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology Books > Medicine > Other branches of medicine > Environmental medicine > General Books > Science & Mathematics > Science: general issues > Scientific equipment & techniques, laboratory equipment > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > General
LSN:	0-89603-443-7
Barcode:	9780896034433

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