Great American Diseases: Their Effects on the Course of North American History presents medical history as it pertains to the major infectious diseases of North America. The book is designed to provide an interesting and engaging introduction to microbiology, immunology and epidemiology. With the advent of COVID-19, this book will serve as a reference on the history of previous epidemics. The book presents pandemics in an easy-to-read volume and provides concise chapters on the history of a disease, progression of understanding on the pathogen (agent of the disease), and their social ramifications through the history of North America.

Anomaly Detection and Complex Event Processing over IoT Data Streams: With Application to eHealth and Patient Data Monitoring presents advanced processing techniques for IoT data streams and the anomaly detection algorithms over them. The book brings new advances and generalized techniques for processing IoT data streams, semantic data enrichment with contextual information at Edge, Fog and Cloud as well as complex event processing in IoT applications. The book comprises fundamental models, concepts and algorithms, architectures and technological solutions as well as their application to eHealth. Case studies, such as the bio-metric signals stream processing are presented -the massive amount of raw ECG signals from the sensors are processed dynamically across the data pipeline and classified with modern machine learning approaches including the Hierarchical Temporal Memory and Deep Learning algorithms. The book discusses adaptive solutions to IoT stream processing that can be extended to different use cases from different fields of eHealth, to enable a complex analysis of patient data in a historical, predictive and even prescriptive application scenarios. The book ends with a discussion on ethics, emerging research trends, issues and challenges of IoT data stream processing.

Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.

Where did Temporary Sobriety Initiatives (TSIs) such as Dry January, FebFast and Ocsober, come from? And what is their role, if any, in prompting people to revisit their relationship with alcohol? These organized campaigns have flourished throughout the English-speaking world in the past decade. Collectively, they involve thousands of participants and raise substantial sums of money for medical research, as well as drug and alcohol related charities. Alcohol, Binge Sobriety and Exemplary Abstinence considers these campaigns as part of a lifestyle movement that transcends single events and even singular national contexts. It uses case studies from Australia, the USA and the UK to examine both the short history of TSIs as a response to problematic localized drinking cultures – including binge drinking – and their relationship to a much longer and transnational history of temperance activism. In taking TSIs as a case study of both embodied philanthropy and participatory health promotion, this book considers how TSIs are structured, promoted and experienced as an embodied event to create imitable, and sometimes contradictory, examples to create a public pedagogy of ‘responsible drinking’.

Designed to support health educators working within the diverse, modern classroom, Culture-Based Differentiated Instruction: A Guide to Teaching Health Education provides readers with a strategic framework that helps them learn about and better understand their students on a cultural level. This teaching methodology equips the educator with the skills to effectively plan, instruct, and assess while designing multiple pathways to success. With this culture-focused pedagogy, educators will be better prepared to make a difference through improving students' health literacy, critical thinking and problem-solving skills, responsible citizenship, and self-directed learning. Each chapter guides readers through a specific component of the Culture-Based Differentiated Instruction Model (CBDIM), while also addressing pedagogy, curriculum, and methodology related to health education. Special focus is given to training educators to manage a spectrum of learners, especially those who are most vulnerable. Individual topics addressed include health disparities, barriers and challenges to understanding cultures, how environmental factors can affect student achievement and health, community outreach, multiple pathways to success, motivating students, managing behavior in the classroom, and more. Culture-Based Differentiated Instruction offers future and current educators with a roadmap and model for effective and impactful teaching in today's multicultural health education classroom and surrounding community.

Individual Participant Data Meta-Analysis: A Handbook for Healthcare Research provides a comprehensive introduction to the fundamental principles and methods that healthcare researchers need when considering, conducting or using individual participant data (IPD) meta-analysis projects. Written and edited by researchers with substantial experience in the field, the book details key concepts and practical guidance for each stage of an IPD meta-analysis project, alongside illustrated examples and summary learning points. Split into five parts, the book chapters take the reader through the journey from initiating and planning IPD projects to obtaining, checking, and meta-analysing IPD, and appraising and reporting findings. The book initially focuses on the synthesis of IPD from randomised trials to evaluate treatment effects, including the evaluation of participant-level effect modifiers (treatment-covariate interactions). Detailed extension is then made to specialist topics such as diagnostic test accuracy, prognostic factors, risk prediction models, and advanced statistical topics such as multivariate and network meta-analysis, power calculations, and missing data. Intended for a broad audience, the book will enable the reader to: Understand the advantages of the IPD approach and decide when it is needed over a conventional systematic review Recognise the scope, resources and challenges of IPD meta-analysis projects Appreciate the importance of a multi-disciplinary project team and close collaboration with the original study investigators Understand how to obtain, check, manage and harmonise IPD from multiple studies Examine risk of bias (quality) of IPD and minimise potential biases throughout the project Understand fundamental statistical methods for IPD meta-analysis, including two-stage and one-stage approaches (and their differences), and statistical software to implement them Clearly report and disseminate IPD meta-analyses to inform policy, practice and future research Critically appraise existing IPD meta-analysis projects Address specialist topics such as effect modification, multiple correlated outcomes, multiple treatment comparisons, non-linear relationships, test accuracy at multiple thresholds, multiple imputation, and developing and validating clinical prediction models Detailed examples and case studies are provided throughout.

Investigative reporter Brian Deer exposes a conspiracy of fraud and betrayal behind attacks on a mainstay of medicine: vaccinations. 2021 IPPY Book Award Winner (Gold) in Health/Medicine/Nutrition, Recipient of the Eric Hoffer Award for Nonfiction in the Culture Category. From San Francisco to Shanghai, from Vancouver to Venice, controversy over vaccines is erupting around the globe. Fear is spreading. Banished diseases have returned. And a militant "anti-vax" movement has surfaced to campaign against children's shots. But why? In The Doctor Who Fooled the World, award-winning investigative reporter Brian Deer exposes the truth behind the crisis. Writing with the page-turning tension of a detective story, he unmasks the players and unearths the facts. Where it began. Who was responsible. How they pulled it off. Who paid. At the heart of this dark narrative is the rise of the so-called "father of the anti-vaccine movement": a British-born doctor, Andrew Wakefield. Banned from medicine, thanks to Deer's discoveries, he fled to the United States to pursue his ambitions, and now claims to be winning a "war." In an epic investigation spread across fifteen years, Deer battles medical secrecy and insider cover-ups, smear campaigns and gagging lawsuits, to uncover rigged research and moneymaking schemes, the heartbreaking plight of families struggling with disability, and the scientific scandal of our time.