Edward Jenner is perhaps the world's most famous doctor. He developed a vaccination for smallpox beginning in 1796, long before the world knew about bacteria and viruses. He has been described as `the man who saved more lives than anyone else'. He bought The Chantry at Berkeley in 1785 and modified it to make a home fit for his beloved wife, Catherine. This book is the result of a three-year investigation that set out to discover the house that Jenner prepared for Catherine. It traces the origin of the house, which was built in 1707, and the many changes throughout the next 300 years. It turns out that the site has a history going back to Anglo-Saxon times. Edward Jenner lived there for only thirty-six years, but the house has been much changed since. The investigation set out to define the house that Edward Jenner lived in, separating it from the original and many changes afterwards. The book includes a great deal of information and stories about the people involved, including Edward Jenner and his family and estate. It also includes the inventory of Jenner's goods in 1823 and profiles of the internal plasterwork, which may be of interest to restorers and historians.