Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development.

Encyclopedia of Environmental Health, Second Edition, Six Volume Set presents the newest release in this fundamental reference that updates and broadens the umbrella of environmental health, especially social and environmental health for its readers. There is ongoing revolution in governance, policies and intervention strategies aimed at evolving changes in health disparities, disease burden, trans-boundary transport and health hazards. This new edition reflects these realities, mapping new directions in the field that include how to minimize threats and develop new scientific paradigms that address emerging local, national and global environmental concerns.

This issue of Clinics in Laboratory Medicine, Guest Edited by Dr. Anand S. Dighe, will focus on Clinical Decision Support, including tools, strategies, and emerging technologies. This issue is one of four issues selected per year by the series Consulting Editor, Milenko Jovan Tanasijevic. Topics include, but are not limited to, The Laboratory's Role in Clinical Decision Support, Integrating Decision Support into a Utilization Management Program, Decision Support Tools within the Electronic Health Record, Decision Support to Enhance Automated Testing and Laboratory Workflow, Laboratory-based CDS programs, Decision Support in Blood Banking, Decision Support in Molecular Pathology, A Computational Perspective on Decision Support, Emerging Decision Support Techniques, Decision Support and Patient Safety, Decision Support from a Reference laboratory perspective, and Training Aspects of Laboratory Based Decision Support.

Electronic Assistive Technology (EAT) is a subset of a wider range of products and services known as Assistive Technology (AT). AT is designed to support and enable people with disabilities, either acquired or congenital, to participate in activities with greater independence and safety. With a global aging population, it has an important role to play in enabling and supporting those with disability and their carers. Handbook of Electronic Assistive Technology discusses a range of commonly available or emerging electronic assistive technologies. It provides historical background, advice when assessing for these devices and references different models of provision. It includes both medical and engineering aspects of provision. It is anticipated that the book will support students, trainees, and newly qualified Assistive Technology Practitioners to develop their understanding of the field, by considering the variables that could potentially influence the decision-making process when assessing for and providing this equipment. It also provides a reference point for those already practicing in this field and offers coverage of a broader range of technologies than clinicians may be exposed to, in their daily work This is the first reference book to focus on a comprehensive set of electronic assistive technologies and discuss their clinical application.

Statistical, Mapping and Digital Approaches in Healthcare addresses all health territories, starting from the analysis of geographical data (health data, population data, health data systems and environmental data), to new health areas (Health 3.0), i.e. digital health territories. Specific tools are used to question environmental changes, such as health statistics, mapping, mathematical models, optimization models and serious games.

A complete case study with all coding sequences from the bacteria Borrellia burgdorferi illustrates how multivariate analyses reveals evolutionary mechanisms acting at the molecular level. They are either mutationnal (symmetric and asymmetric directionnal mutation pressure) or selective (selection against head-on collisions or linked to gene expressivity or subcellular location).

Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

This book is a collective work draws on the perspective of social sciences, mobilizing perspectives from the sociology of science, the history of psychiatry, medical ethnography and public policy analysis. This initiative, which has no precedent in social sciences, is surrounded by an original, if not apparently paradoxical statement: considering that the deployment of these processes, strictly formal and depersonalized, is justified in becoming the rule in a society known as "individuals".

Healthcare Data Analytics and Management help readers disseminate cutting-edge research that delivers insights into the analytic tools, opportunities, novel strategies, techniques and challenges for handling big data, data analytics and management in healthcare. As the rapidly expanding and heterogeneous nature of healthcare data poses challenges for big data analytics, this book targets researchers and bioengineers from areas of machine learning, data mining, data management, and healthcare providers, along with clinical researchers and physicians who are interested in the management and analysis of healthcare data.

The Pfizer Papers features new reports written by WarRoom/DailyClout research volunteers, which are based on the primary source Pfizer clinical trial documents released under court order and on related medical literature. The book shows in high relief that Pfizer’s mRNA COVID-19 vaccine clinical trial was deeply flawed and that the pharmaceutical company knew by November 2020 that its vaccine was neither safe nor effective. The reports detail vaccine-induced harms throughout the human body, including to the reproductive system; show that women suffer vaccine-related adverse events at a 3:1 ratio; expose that vaccine-induced myocarditis is not rare, mild, or transient; and, shockingly, demonstrate that the mRNA vaccines have created a new category of multi-system, multi-organ disease, which is being called “CoVax Disease.”

Despite the fact that Pfizer committed in its own clinical trial protocol to follow the placebo arm of its trial for twenty-four months, Pfizer vaccinated approximately 95 percent of placebo recipients by March 2021, thus eliminating the trial’s control group and making it impossible for comparative safety determinations to be made.

Just as importantly, The Pfizer Papers makes it clear that the US Food and Drug Administration knew about the shortfalls of Pfizer’s clinical trial as well as the harms caused by the company’s mRNA COVID vaccine product, thus highlighting the FDA’s abject failure to fulfill its mission to “[protect] the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices.”

The Pfizer Papers offers an in-depth look at how Big Pharma, the US government, and healthcare entities stand protected behind the broad legal immunity provided by the Public Readiness and Emergency Preparedness Act (PREP Act) when creating, prescribing, and administering vaccines; and, under that shield of protection, do what is best for their bottom lines rather than for the health and well-being of Americans.

Advances in Food and Nutrition Research, Volume 85, provides updated knowledge on nutrients in foods and how to avoid their deficiency, especially the essential nutrients that should be present in the diet to reduce disease risk and optimize health. The book provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits. Readers will find up-to-date information on food science, including raw materials, production, processing, distribution and consumption, with an emphasis on nutritional benefits and health effects. New sections in the updated volume include discussions on the biological and biomedical applications of egg peptides, omega-3 fatty acids and liver diseases in children, the characterization of the degree of food processing in relation to health, the impact of unit operations from farm to fork on microbial safety and quality of foods, new trends in the uses of yeasts in oenology, and more.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource.

Sphingolipids in Cancer, Volume 140, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Topics discussed in this updated volume include Mechanisms of ceramide-dependent cancer cell death, Sphingolipids as regulators of autophagy and endocytic trafficking, The role and function of sphingomyelin biosynthesis in the development of cancer, Neutral sphingomyelinases in cancer: Friend or foe?, Sphingolipid rendezvous at the crossroad of NAFLD and senescence, Ceramide signaling and p53 pathways, Sphingolipid regulation of RNA Biology in cancer phenotypes, The role of ceramide-1-phosphate in tumor cell survival and dissemination, and more.

Therapeutic, Probiotic and Unconventional Foods compiles the most recent, interesting and innovative research on unconventional and therapeutic foods, highlighting their role in improving health and life quality, their implications on safety, and their industrial and economic impact. The book focuses on probiotic foods, addressing the benefits and challenges associated with probiotic and prebiotic use. It then explores the most recently investigated and well-recognized nutraceutical and medicinal foods and the food products and ingredients that have both an impact on human health and a potential therapeutic effect. The third and final section explores unconventional foods and discusses intriguing and debated foods and food sources. While research has been conducted on the beneficial biological effects of probiotics and therapeutic food, the use of these foods remains controversial. To overcome the suspicion of the use of alternative, homeopathic and traditional products as therapy, this book reveals and discusses the most recent and scientifically sound and confirmed aspects of the research.

Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks under random genetic variations and environmental disturbances and their application to systematic synthetic biology design. The book provides more realistic stochastic biological system models to mimic the real biological systems in evolutionary process and then introduces network evolvability, stochastic evolutionary game theory and strategy based on nonlinear stochastic networks in evolution. Readers will find remarkable, revolutionary information on genetic evolutionary biology that be applied to economics, engineering and bioscience.

Anxiety, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on the roles that hormones and other factors play in anxiety and stress. Each volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors, and others thoroughly reviewed.

Global Health Informatics: How Information Technology Can Change Our Lives in a Globalized World discusses the critical role of information and communication technologies in health practice, health systems management and research in increasingly interconnected societies. In a global interconnected world the old standalone institutional information systems have proved to be inadequate for patient-centered care provided by multiple providers, for the early detection and response to emerging and re-emerging diseases, and to guide population-oriented public health interventions. The book reviews pertinent aspects and successful current experiences related to standards for health information systems; digital systems as a support for decision making, diagnosis and therapy; professional and client education and training; health systems operation; and intergovernmental collaboration.

Motivation: Theory, Neurobiology and Applications is inspired by a question central to health care professionals, teachers, parents, and coaches alike, "How can an individual be motivated to perform a given activity or training?" It presents novel measurements of motivation developed in psychology and economics, recent insights into the neurobiology of motivation, and current research on applications designed to boost motivation in neurorehabilitation, education, and sports. In addition, tactics on how to connect these different research and knowledge fields within a common (theoretical) framework of motivation is discussed. Thus, in short, the book provides an integrative, interdisciplinary, up-to-date accounting on the neurobiology of motivation and how it might be boosted.

Physician Assistant Clinics aims to provide an authoritative and continuously updated clinical information resource that covers all of the relevant PA specialties. Our clinical review articles address the key points, diagnosis, prognosis, clinical management, and complications of disease and techniques, evidence, and controversies in the field. Information for quick reference, as well as in-depth coverage of a topic, is a hallmark of the Clinics' series. This issue of Physician assistant Clinics, guest edited by Kim Zuber, PA-C and Jane S. Davis, DNP, CRNP, brings together expert PAs, NPs, and MDs to give PAs deep insights into the latest advancements in renal disease and show how they are applicable in practice. Articles in this issue include: Will the Real Kidney Patient Please Stand Up?; Introduction of the Kidney Patient; The Surgical Kidney Patient; CardioRenal: The Pump and the Filter; Dosing the Kidney Patient; ABCs of the ICU; Pediatrics: Forgotten Stepchild of Nephrology; Acute Kidney Injury (AKI); Outpatient Management of the CKD Patient; Nephrolithiasis: The Rolling Stones; Transplant and the New Protocols; Health Disparities in Kidney Disease; and Diet and the Kidney.

"We have to adapt to the impacts that, unfortunately, we can no longer avoid", said President Obama at the UN Climate Summit in September 2014. Adaptation and resilience are now a must in both academic research and international bodies. A fashionable concept, resilience's polysemy sparks many debates on its uses and operational relevance. This book bridges the increasing divide between academic research and the latest planning innovations, offering practical and conceptual insights for practitioners, researchers and students. Magali Reghezza-Zitt and Samuel Rufat present a cross-disciplinary, state-of-the-art debate and critical analysis of the social, spatial, practical and political implications of resilience.

The Oregon State Insane Asylum was opened in Salem on October 23, 1883, and is one of the oldest continuously operated mental hospitals on the West Coast. In 1913, the name was changed to the Oregon State Hospital (OSH). The history of OSH parallels the development and growth in psychiatric knowledge throughout the United States. Oregon was active in the field of electroshock treatments, lobotomies, and eugenics. At one point, in 1959, there were more than 3,600 patients living on the campus. The Oscar-winning movie One Flew Over the Cuckoo's Nest was filmed inside the hospital in 1972. In 2008, the entire campus was added to the National Register of Historic Places, and the state began a $360-million restoration project to bring the hospital to modern standards. The story of OSH is one of intrigue, scandal, recovery, and hope.

This issue of Clinics in Geriatric Medicine is devoted to Nutrition in Older Adults. Guest Editor John E. Morley, MD has assembled a group of expert authors to review the following topics: Anorexia of Aging; Protein and Older Persons; Screening for Malnutrition in Older People; Obesity and Aging; Vitamins; Sarcopenia; Diabetes: Nutrition and Exercise; Frailty, Exercise and Nutrition; Dehydration; Cholesterol and Older Persons; Cognition and Nutrition; and Gastric Emptying in the Elderly.

Drs. Richard Carlson and Corey Scurlock have put together a cutting edge list of topics regarding the use of Telemedicine in the Intensive Care Unit. Topics include: Tele-Neurocritical Care, Outcomes related to Telemedicine in the ICU,Telemedicine in the ICU: Its role in Emergencies and Disaster Management,Increasing Quality through Telemedicine in the ICU,The Role of Telemedicine in Pediatric Critical Care,Telemedicine and the Septic Patient,Taking Care of the Cardiac Critical Care Patient with Telemedicine,Barriers to ICU telemedicine,and Design and Function of Tele-ICU.