Understand and assess the design, delivery, and efficacy of orally administered drugs

A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.

The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen.

This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.

In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches--Caco-2 cell culture model, MDCK, and other related cell culture models--which are used to study the science of oral bioavailability.

This completely revised edition of Men, Women, Passion and Power offers a new critique of conventional notions of masculinity and femininity. Contemporary psychoanalytic debates about sexuality are explored, revealing how the cultural idealisation of men is replicated in theory and clinical practice. Illustrated with use of detailed and vivid case material, this book demonstrates that it is only when the feminist perspective has been truly integrated into theory that the psychoanalytic project will realise its full radical potential. Subjects covered include: * The power of female sexuality * Race, class and sexuality * The fragility of male sexual identity * Envy between the sexes. Marie Maguire argues that examining these issues and gaining an awareness of how our assumptions are influenced by social inequalities can enrich the psychotherapeutic process and result in a more balanced psychological relation between the sexes. Men, Women, Passion and Power will be of great interest to psychotherapists, psychoanalytic practitioners and anyone with an interest in the integration of a feminist perspective into psychoanalytic theory.

Writing is our cultural medium and can be used to enhance counselling and psychotherapy - just writing in itself can be therapeutic. The onset of online therapy means that increasing numbers of therapists need to know about this valuable means of communication.

Writing Cures demonstrates power of expressive and reflective writing in the context of therapy, whether online or text-based, enabling the practitioner to undertake writing methods with clients. It introduces the reader to therapeutic writing in a range of settings and contexts, and from a range of approaches. Chapters from an impressive list of
contributors include:

OCo 'Ethical and Practical Dimensions of Online Writing Cures' by Stephen Goss and Kate Anthony
OCo 'Writing by Patients and Therapists in Cognitive and Analytic Therapy' by Anthony Ryle
OCo 'Reflective and Therapeutic Writing in Counsellor Training' by Colin Feltham and Jacquie Daniels.

Illustrated throughout from clinical experience Writing Cures will be of benefit to all counsellors and
psychotherapists.
"

Dual language learners are the fastest-growing segment of the U.S. student population, and the majority speak Spanish as a first language. This graduate-level textbook—now in its third edition—gives future speech-language pathologists the comprehensive knowledge they need to work effectively with Spanish–English bilingual children and support their language development. Aligned with current best practices and updated with the latest research and new chapters on critical topics, this book prepares SLPs for practice with cutting-edge information on language development and disorders of Spanish–English bilingual children. More than 25 leading researchers compile the high-level knowledge SLPs need to understand the complexity of language development in bilingual children, distinguish language differences from disorders accurately, and conduct effective assessment and intervention. An essential graduate text that will also be a trusted reference for practicing professionals, this third edition gives current and future SLPs a broad, deep, and nuanced understanding of communication development and disorders in Spanish English bilingual children. NEW CHAPTERS ON: the human right to communicate in more than one language • development of speech perception and production in bilingual preverbal infants • culturally and linguistically responsive approaches to language intervention. UPDATED INFORMATION ON: bilingual language development of English learners • bilingualism and the child socialization process • bilingual lexical development, assessment, and intervention • semantic development • grammatical impairments • morphosyntactic development • cross-linguistic influence and code-switching • oral narrative language skills and disorders • first language loss and attrition • literacy learning • the intersection of language and academics • speech sound development and disorders • fluency • professional development practices.

Sakkiya is a Hausa word, which has its origin from the Hausa culture, and it means the act of using hot pointed metallic tip to puncture bodily swelling with the aim of achieving a curative effect. The Hausa culture is one of the three most popular cultures in Nigeria. The Hausas are predominantly located in the northwestern geopolitical zone of Nigeria, predominantly working as farmers. The majority of the Hausa people practice the Islamic religion. Encounters from the medical setting with cases of complications arising from failure of Sakkiya treatment, where some patients did not survive this treatment made investigation into this form of alternative medicine a paramount issue. In order to fill the void of information and literature on Sakkiya treatment, the authors embarked on a literature search and field studies resulting in this book. The authors found a lack of historical evidence concerning the old traditional Sakkiya practice, and therefore urge archaeologists, anthropologists, sociologists and historians to investigate into the historical evolution of Sakkiya practice in northern Nigeria.Kehinde Kanmodi, BDS, ACIPM, AISQEM is a dental surgeon, lecturer, multidisciplinary researcher, and manager affiliated with Cephas Health Research Initiative Inc, Ibadan (head office), Community Health Officers Training Programme, Usmanu Danfodiyo University Teaching Hospital, Sokoto, National Teachers Institute, Department of Political Science of the National Open University of Nigeria, Abuja, Nigerian Institute of Management, Abuja, Chartered Institute of Project Management, Lagos, and Dental Clinic, Kebbi Medical Centre, Kalgo, Nigeria.Joav Merrick, MD, MMedSci, DMSc, born and educated in Denmark is professor of pediatrics, child health and human development affiliated with the Division of Pediatrics, Hadassah Hebrew University Medical Center, Mt Scopus Campus, Jerusalem, Israel, Kentucky Childrens Hospital, University of Kentucky, Lexington, United States and professor of public health at the Center for Healthy Development, School of Public Health, Georgia State University, Atlanta, United States, the former medical director of the Division for Intellectual and Developmental Disabilities, Ministry of Social Affairs and Social Services, Jerusalem and the founder and director of the National Institute of Child Health and Human Development in Israel.

In this award-winning memoir, you’ll meet Hannah, a young girl who has a promising future until she suddenly spirals into sex, drugs, alcohol, and other high-risk behaviors. Off the Rails: One Family’s Journey Through Teen Addiction narrates Hannah’s decline and subsequent treatment through the raw, honest, compelling voices of Hannah and her shocked and desperate mother―each one telling her side of the story. Fearing that they couldn’t keep their teen safe, Hannah’s parents make the agonizing decision to send her to a wilderness program, and then to residential treatment. Off the Rails tells the story of the two tough years Hannah spent in three separate programs―and ponders the factors that contributed to her ultimate recovery. Written for families facing challenges and those that wish to support them, Off the Rails is an inspiring story of love, determination, and a last-resort intervention, as a mother and daughter lose, and then try to find each other again.

Effective, "integrated" care across clinical, classroom, and home settings: that's what every student with ADHD needs to achieve academic and social success. Now professionals have one complete, highly accessible guide to delivering this kind of coordinated treatment for children in Grades 1-8. Aligned with the AAP's new guidelines for ADHD management, this essential resource is the key to developing a comprehensive treatment program--one that combines the expertise of school psychologists, educators, primary care providers, and the child's family. Professionals will get practical, research-based guidelines that help with every stage of ADHD management, including

• conducting universal and individual screening for ADHD and comorbid disorders
• accurately diagnosing ADHD using in-depth information from parents and the other professionals who work with the child
• using today's most effective interventions for ADHD, with detailed discussion of both psychotropic medications and behavioral strategies in home and school settings
• developing successful classroom-based strategies that combine the contributions of teachers, parents, peers, and the child himself
• managing the functional impairments associated with ADHD, including difficulties with academic performance and relationships with peers and authority figures
• adopting a family-centered approach, so parents are true partners in the diagnosis and management of ADHD
• maintaining open, coordinated communication between the family, primary care provider, educators, mental health clinicians, and other professionals

An ideal professional development resource for clinicians and educators, this book will help every adult in a child's life contribute to coordinated ADHD care that really improves outcomes.

When did our obsession with wellness start making us sick? Hear Me Raw is an autobiographical play based on the author's experiences of the online wellness industry. The play opens with the protaganist playing the typical health blogger: "She has constructed, with uncanny accuracy, that suspiciously ‘together’ person, the constant smile and unsolicited advice perfected."(A Younger Theatre). As the play progresses we see how this young woman's desire for 'clean living' becomes a deepening obsession with restriction and control. It isolates her from others, disconnecting her from family and friends, so that she selfishly does not attend a family shiva because of her food obsessions. Her controlled regimes also significantly affect her mental health.  Daniella Isaacs peels back the Instagram filter to reveal the dirty truth behind clean living. Hear Me Raw is an autobiographical account of one woman’s journey through the world of contemporary wellness. A blistering piece of theatre about restriction, control and too much turmeric.

The Audiogram Workbook provides students with essential practice in reading and interpreting audiograms. Each case begins with a case history and audiogram, followed by the correct interpretation on the next page. Key Features: More than 100 cases covering a wide range of audiologic conditions Written by promising young audiologists at Washington University in St. Louis, Missouri, one of the top audiology programs in the U.S. Each case allows the reader to view and correctly interpret audiograms and to understand case history writing Practice audiograms provide students with a "clean slate" to write and create a case history based on audiogram and then interpret results The Audiological Interpretation Cheat Sheet assists readers in interpreting audiograms during clinical rotations This workbook is an excellent resource for audiology students who need to learn the skill of audiogram interpretation.

This user-friendly manual guides professionals through the process of administering, scoring, and interpreting the Communication and Symbolic Behavior Scales (CSBS™), one of the best measures of early communication in children 8–24 months (or up to 72 months if developmental delays are present). The manual includes: a concise question-and-answer introduction to CSBS™ informative summaries that reveal how the communication and symbolic behavior scales were developed detailed, easy-to-follow instructions on how to administer the Caregiver Questionnaire, conduct each part of the videotaped Behavior Sample, and interpret the behaviors on the videotape clear guidelines on rating, summarizing, and interpreting scores technical data about CSBS™, including information about standardization, scaling and norming, reliability, and validity helpful tips on planning individualized interventions Filled with tables, charts, and checklists that summarize key points, clarify technical data, and help users organize the information and material they need, this manual will make it easier for professionals to use CSBS™ effectively with the children and families they serve. This manual is part of CSBS™, a norm-referenced, standardized tool that uses parent interview and direct observation to assess infants, toddlers, and preschoolers at risk for communication delays and impairments. With 22 rating scales that accurately survey children's language skills and symbolic development, CSBS is backed by technical data and compatible with most developmental curricula in use today.

Every inclusive school team needs a great SLP who supports communication skills where they’re needed most—in the classroom, as students with disabilities learn and participate alongside their peers. This is the practical, friendly guide SLPs need to go beyond pull-out services and deliver successful communication and language supports as part of an inclusive school team. Packed with immediately useful strategies, relatable examples, and invaluable insights from experienced SLPs, this guidebook is key to helping students with disabilities improve their communicative functioning so they can access the curriculum and fully participate in classroom routines and activities. New and seasoned SLPs will turn to this book again and again for clear guidance on succeeding in an inclusive classroom and helping all students reach their full potential. STRATEGIES THAT HELP SLPs: provide effective communication and language supports within the classroom environment collaborate with other members of the school team promote higher academic achievement through communication supports help facilitate peer supports and friendships choose accommodations and modifications that improve communication and participation match supports to students’ specific strengths keep expectations high for all students maximize student independence respond to challenging behavior in gentle, positive ways PRACTICAL MATERIALS: Tools and checklists to help plan and communicate a speech-language therapy plan, choose student supports, clarify team roles and responsibilities, presume competence, and more.

Clinics in Developmental Medicine No. 188

This book documents the consequences of the exposure of infants to the influence of intrauterine chemicals. In setting out the evidence for these outcomes, the authors demonstrate that decisions about care and management can and should be made as early as possible. This should allow professionals to provide protective management and prevent the delays that are so often seen in this area of medical and social care.

The international team of contributors sets out to inform the reader of the potential risks to infants exposed to a range of intrauterine chemicals that are potentially neuroactive, including medicinal drugs such as antiepileptics, antidepressants and antipsychotics, as well as drugs of abuse, including alcohol, opiates, and recreational drugs such as cannabis and tobacco. They review the teratogenic action of some of the chemical processes and the relationship of exposure to the stage of pregnancy. Some agents alter anatomic structure; others alter the chemical balance of neurotransmitters and may thus alter the regulation of brain function, with profound effects on the child's behaviour and propensity to behavioural disturbances. The book explores strategies to support these children and those who care for them, including statutory agencies.

Readership
Paediatricians, neonatologists, obstetricians, gynaecologists, child and adolescent psychiatrists and psychologists, those working in child care and child protection.

Who is the typical alcoholic among the 12.5 million living in the United States now? Many, if not most of us when asked that question, would envision a skid row bum or someone at least out of work or with little education locked into a low-skill, low-paying job. But that is not accurate, according to the results of a national study released in June, 2007 by the National Institutes of Alcohol Abuse and Alcoholism. The NIAAA determined that alcoholics in the United States really fall into five subtypes, including nearly 20 percent who are highly functional alcoholics, well-educated with good incomes. They include corporate presidents, powerful politicians, police, lawyers, doctors, scientists, and other highly-skilled, highly-educated people who are middle- to high-income and by most accounts successful. In this unprecedented book, mental health counselor Sarah Benton takes us into the worlds and minds of so-called high-functioning alcoholics, to understand how people so intelligent and achievement-oriented get drawn into states in which they secretly cannot control their liquor consumption but still manage to excel in their careers.

The book includes a look at celebrity alcoholics like singer Eric Clapton and actor/comedian Robin Williams, as well as alcoholics in high positions including Chris Albrecht, former Chairman and CEO of HBO. Other high-profile people included in this book are Miss USA 2007 Tara Conner and football legend Joe Namath. With her own story of alcoholism and her recovery woven into the text, Benton takes us into the lives and challenges of these well-educated and successful people, seeking to understand how, when, and why they became addicted, as well as the reasons their alcoholism is, for most, so hard to admit, cope with, and recover from.

Essential Counseling and Therapy Skills is written for trainees who are beginning to work with clients under supervision. Building on what has been learnt during introductory courses, the book supports students in the next stage of their practical skills development.

Written by leading author, Richard Nelson-Jones, Essential Counseling and Therapy Skills is a step-by-step guide to therapeutic work using the "skilled client model". Central to this innovative approach, is the assumption that the skill of counselors and therapists lies in their capacity to impart skills to clients. The book focuses on: establishing collaborative working relationships; working with clients to find shared definitions of their problems; enabling clients to improve how they think, communicate and act; and dealing with questions of diversity, ethical practice and the value of supervision.

Accessibly written, the book contains numerous skills building activities and case examples, making Essential Counseling and Therapy Skills an ideal textbook for practical skills training in counseling, counseling psychology, psychotherapy and other helping professions. 

This newly updated edition of the top-selling reference manual for the medical evaluation of suspected child sexual abuse has been expanded to reflect the increasing importance of properly performed, well-documented examinations. Not only does the book cover aspects of the physical examination and diagnosis for sexual abuse, its additional coverage of interviewing children and collecting evidence for criminal investigations makes it an inclusive guidebook for all aspects of the child sexual abuse evaluation process.

Each day, case managers, psychiatric nurses, and other mental health professionals interact with adults who have a history of physical and/or sexual abuse during childhood. Many of these important professionals will often be the first practitioners to hear about a client?s background of abuse, but they may not have specialized training in understanding and working with survivors of childhood trauma. The Link Between Childhood Trauma and Mental Illness gives mental health professionals who are not child abuse specialists knowledge and skills that are especially relevant to their direct service role and practice context. It introduces to these practitioners a conceptual bridge between biomedical and psychosocial understandings of mental disorder, providing a multidimensional approach that allows professionals to think holistically and connect clients? abusive pasts with their present-day symptoms and behaviors. Building upon this conceptual foundation, the book then focuses on direct practice issues, including how to ask clients about child abuse, the nature of power in the helping relationship, the full recovery process, effective treatment models, client safety issues, and ways to listen to client?s stories. Also included are valuable insights into helping clients who are in a crisis situation, the particular needs of male victims of child abuse, racial and cultural considerations, and the professional?s self-care. Designed to meet the needs of such helping professionals as case managers, psychiatric nurses, rehabilitation counselors, crisis and housing workers, occupational and physical therapists, family physicians, and social workers, The Link Between Childhood Trauma and Mental Illness is an accessible and convenient guide to understanding the effects of childhood abuse and incorporating that understanding into direct practice.

Each day, case managers, psychiatric nurses, and other mental health professionals interact with adults who have a history of physical and/or sexual abuse during childhood. Many of these important professionals will often be the first practitioners to hear about a client?s background of abuse, but they may not have specialized training in understanding and working with survivors of childhood trauma. The Link Between Childhood Trauma and Mental Illness gives mental health professionals who are not child abuse specialists knowledge and skills that are especially relevant to their direct service role and practice context. It introduces to these practitioners a conceptual bridge between biomedical and psychosocial understandings of mental disorder, providing a multidimensional approach that allows professionals to think holistically and connect clients? abusive pasts with their present-day symptoms and behaviors. Building upon this conceptual foundation, the book then focuses on direct practice issues, including how to ask clients about child abuse, the nature of power in the helping relationship, the full recovery process, effective treatment models, client safety issues, and ways to listen to client?s stories. Also included are valuable insights into helping clients who are in a crisis situation, the particular needs of male victims of child abuse, racial and cultural considerations, and the professional?s self-care. Designed to meet the needs of such helping professionals as case managers, psychiatric nurses, rehabilitation counselors, crisis and housing workers, occupational and physical therapists, family physicians, and social workers, The Link Between Childhood Trauma and Mental Illness is an accessible and convenient guide to understanding the effects of childhood abuse and incorporating that understanding into direct practice.

Rebuilding Communities: Challenges for Group Work is a collection of research and information presented at the 18th Annual Symposium of the Association for the Advancement of Social Work with Groups. Social workers, students, educators, and practitioners will examine how group work can improve multicultural relations within the community. Through your use of the valuable suggestions in this book, you will discover new ways to help the poor in your community help themselves, while giving them a sense of power and self-esteem to help them battle racism, sexism, and shrinking economic opportunities. Through Rebuilding Communities, you will also discover a formula for global group work that will help you make a difference by applying your hometown skills to the global community. This valuable book discusses the need for you to combine energy with humility, offer assistance with the ability to listen, to intervene when necessary, and to comprehend diversity for successful and beneficial group programs. This informative guide brings to light the skills and values needed for effective group work and how combining knowledge-base and practice-base will assist you in making a positive impact on your community. With this important book, you will find a rich source of current thinking about group work practice in relation to women, violence, health problems, child welfare, and other areas, as well as group work theory to help you find the best way to help the various people of your community. Rebuilding Communities will provide you with specific ways to improve your group work skills and positively affect the individuals in your community, such as: learning that your role of caring and advocacy as a group worker must be a complete and lifelong commitment and that you must be prepared to use your skills throughout your everyday life to make a difference using the World Wide Web to form groups whose members can support one another through the anger, joy, pain, and challenges of life learning how group work can help calm the stormy transitions that adolescent immigrants face by helping them relate to other children who are in similar circumstances examining how parents of pediatric urology patients find solace through groups where they can address such sensitive issues as the future of sexual functioning and fertility for their children discovering how marathon group sessions in South Africa are helping to provide basic services to the disadvantaged with programs to facilitate interracial contact and understanding among women and programs for adolescents boys in foster careRebuilding Communities offers you a deeper understanding of the total positive effect that group work can have on various sectors of your community to help you provide better services to those in need. This unique book focuses your attention on the importance of group work to community development and even provides you with a glimpse into the future of group work. With Rebuilding Communities you will discover a multifaceted approach to solving problems that communities face to help you choose the best options for your own community and give the best possible services to the people you assist.

This text is taken from the proceedings of a Conference on medical response to effects of ionizing radiation held at Queen Elizabeth II Conference Centre, London, UK, 28-30 June 1989.

""The aspects of the book related to the philosophy of science and cognitive science (inductive and deductive reasoning, biases, and heuristics) are distilled in reasonable and useful ways. I recommend this book to those addiction professionals who want to create their own framework for ethical decision making.""

"--PsycCRITIQUES"

Ethical decision-making is required in many of the difficult situations faced by addiction professionals. In this guide, Michael Taleff describes how to integrate critical thinking with ethical decision-making. This is a guide not on "what to do" when confronted with difficult ethical dilemmas, but on how to think about what to do.

The author presents common ethical dilemmas that addiction professionals face in their daily work--such as boundary issues, confidentiality, dual relationships, and more--and asks readers to consider their own responses to these dilemmas. The book then shows readers how to apply new models of ethical thinking to practice.

Key features: Presents an ethical self-exam to encourage critical thinking about one's own decision-making method Introduces a variety of models such as the social contract theory, existentialist theory, and ethical egoism Discusses how biases, emotional reactions, and fallacies can weaken ethical decision-making Presents an introductory "Ethics Judgment Kit," a simple, practical decision-making procedure for students

This book demonstrates how critical thinking skills can impact and improve the process of ethical decision-making.