"Electroporation-Based Therapies for Cancer" reviews electroporation-based clinical studies in hospitals for various cancer treatments, including melanomas, head and neck cancers, chest wall breast carcinomas, and colorectal cancers, as well as research studies in the lab using cell lines, primary cells, and animals.

Cancer kills about one American per minute, amounting to over 500,000 deaths in the United States and millions, worldwide, each year. There is a critical need for safe, effective, and affordable alternative treatment modalities, especially for inoperable, recurring, and chemo-resistant cancers, that do not respond well to current treatment regimen. An electrical-pulse-mediated, enhanced drug delivery technique known as electroporation is one way to effectively treat these patients.

This technique is especially suitable for low- and middle-income countries, where lack of infrastructure and resources leads to cancer diagnoses at late stages. This quick, safe, effective, economical, out-patient-based technique is a boon to these patients for palliative and other care with enhanced quality of life. This book features discussions by interdisciplinary authors-including practicing oncological surgeons, medical professionals, and academic and other researchers-of the basics and clinical medical applications of electroporation.
Provides novel and recent clinical applications of electrochemotherapy for various cancers, including melanomas, sarcomas, superficial extreme melanoma, chest wall breast carcinoma, and colorectal cancersExtensive study of a number of cell lines, including human breast cancer, lung cancer, cervical cancer, leukemia, and mouse breast cancer using both reversible and irreversible electroporation techniquesIn vitro study of delivery of various commonly prescribed/administered breast cancer chemo and hormone drugs, such as Doxorubicin, Paclitaxel, Bleomycin, and Tamoxifen

Approx.230 pages

This self-help book explores the problems created by having ready access to high fat foods designed to taste good. Because we evolved in conditions of relative scarcity we have few natural food inhibitors and so most diet books try to encourage people to inhibit their eating by highly rule governed behaviours which have to be constantly worked at. However, this can lead to various forms of self-criticism which can undermine efforts at self-control. As a result our relationship with eating can be complex, multifaceted and problematic. This workbook uses a compassionate therapeutic approach to help us understand and work with our urges and passions for food. We can learn to enjoy and accept food and pay attention to our biological and emotional needs. The Eating Well Workbook is for people who have tried diets and found that they don't work and will enable the reader to have a healthier and happier relationship with food and their body. THE COMPASSIONATE MIND APPROACH The self-help books in this series are based on the Compassionate Mind Approach (developed by series editor Paul Gilbert). This brings together an understanding of how our mind can cause us difficulties but also provides us with a powerful solution in the shape of mindfulness and compassion. It teaches ways to stimulate the part of the brain connected with kindness, warmth, compassion and safeness, and to calm the part that makes us feel anxious, angry, sad or depressed.

Pancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observation that the regenerative medicine field is progressing at such a fast pace that the way we currently think and practice transplant medicine is rapidly changing, faster than we could ever imagine. This series was therefore conceived to bring together experts from both the transplant and regenerative medicine fields, to share knowledge first, but also to introduce the transplant audience to the remarkable progress that has occurred in regenerative medicine over the past few decades. At the same time, we intend to illustrate to researchers and operators in the regenerative medicine field the numerous platforms that transplant medicine offers for the application of their technologies. To the publisher and the editors of this series and volumes there is no doubt that regenerative medicine will shape and define the future of transplant medicine. This volume focuses on pancreas and beta cell replacement and illustrates how progress in biomaterial sciences, stem cell biology, gene editing, cell, tissue and organ bioengineering and regeneration, along with advances in xenotransplantation are revolutionizing the field. Written by the world's experts in the fields of pancreas, islet and xenotransplantation, as well as regenerative medicine, it represents a valuable educational tool for those in the fields of clinical transplantation, researchers in the field of regenerative medicine, transplant medicine, diabetes and immunology, as well as for medical and health science students, those in academia, the biotech industry and regulatory agencies working to advance the field. At the end of the book, it will become clear to the reader that beta cell replacement offers a vast array of platforms for the application of regenerative medicine technologies to transplant medicine.

iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Molecular Players in iPSC Technology, Volume 12 addresses the molecular players underlying induced pluripotent stem cell (iPSC) generation, maintenance, expansion, and differentiation. The discovery of iPSCs revolutionized biomedical research. iPSC technology involves multiple molecular mechanisms. This volume covers exosomal microRNAs, auxiliary pluripotency-associated genes, inducible caspase-9 suicide gene, cell cycle proteins, ion channels, Notch signaling, kinase signaling, SOCS3/JAK2/STAT3 pathway, NANOG, Kruppel-like factors, H1FOO, and much more in iPSCs. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field.

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Methods in iPSC Technology, Volume 9 addresses the different methods used for induced pluripotent stem cell (iPSC) formation, maintenance, expansion, and differentiation. The ability to reprogram different cell types to iPSCs offers an opportunity to generate pluripotent patient-specific cell lines that can help in the understanding of multiple human disorders. This volume addresses a variety of current methods used in the generation and manipulation of iPSCs, such as magnetic nanoparticles, piggyBac vectors, lentiviral vectors, bioscaffolds, somatic cell nuclear transfer, CRISPR/Cas9, bacteria, and much more. This volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

Struggling to help someone you love as they battle an eating disorder? This book will arm you with the knowledge, understanding and skills you need to be able to help your loved one towards recovery. Psychologist and eating disorder specialist Dr Pamela Macdonald has been working with carers for over a decade. Here, she uses the established New Maudsley Approach, an evidence-based therapy toolkit which equips carers with the communication skills they need to best help their loved one. Dr Macdonald has personal experience of the effects that an eating disorder can have on the entire family and strongly believes that carers and parents are a crucial element to the recovery process.

A four year old Mexican American girl is taken away from her parents because she is obese and experiencing health problems related to her weight. Such a measure, once seen as extreme, quickly comes to be seen as a logical means of addressing a problem viewed as nothing short of child abuse. And yet, for all the purported concern for these children's welfare, little if any mention is ever made of the psychological ramifications of removing children from their families. They are simply the latest victims of the war on obesity--a war declared on a "disease" but conducted, April Herndon contends in this book, along cultural lines.

"Fat Blame" is a book about how the war on obesity is, in many ways, shaping up to be a battle against women and children, especially women and children who are marginalized via class and race. While conceding that fatness can be linked to certain conditions, or that some populations might be heavier than others, Herndon is more interested in the ways women and children are blamed for obesity and the ways interventions aimed at preventing obesity are problematic in and of themselves. From bariatric surgeries being performed on children to women being positioned as responsible for carrying to term a generation of thin children, her book looks closely at the stories of real people whose lives are drastically altered by interventions that are supposedly for their own good.

As with so many practices surrounding bodies and health, like dieting, people are often simultaneously blamed and empowered through policies and interventions, especially those that seem to offer them choices. What Herndon reveals is how such choices only offer the illusion of being empowering. Rather, she shows how woman and children are pushed, pulled, and sometimes victimized by interventions such as bariatric surgeries, limits on reproductive technologies, and having their families broken up by the courts. Only by identifying members of this group as victims of discrimination, she argues, can we hope to return them to a fuller and richer kind of agency.

In declaring a war on obesity, the United States has said that fat is one of the most serious enemies it faces. "Fat Blame" asks us to confront the real enemy--the moral, political, and ideological significance of our every move in this "war."

Part of the trusted Kryger line of sleep medicine references, Kryger's Sleep Medicine Review, 3rd Edition, tests your knowledge with over 1,000 questions and answers, both in print and online. This unique review tool follows the updated AASM exam blueprint, providing authoritative guidance and current information on every aspect of sleep medicine. It's an invaluable resource for test prep and clinical practice, with updates to the classification system (ICSD3) and scoring manual, a new section on instrumentation, and questions related to key topics such as home sleep testing. Tests your knowledge with 540 in-book questions, and 520 additional questions online in a testing module that indicates which questions are answered correctly or incorrectly. All questions correspond to the blueprint of the newly updated AASM exam. Includes a new section on instrumentation and testing that covers electrical components and technical aspects of sleep devices as well as guidance on sleep study preparation and testing conditions. Features increased content on pediatrics and management of children transitioning into adulthood, with many new pediatric-specific cases and questions. Keys answers to the relevant sections of Dr. Kryger's Principles and Practices of Sleep Medicine as well as the Atlas of Clinical Sleep Medicine. Brings you up to date with recent changes in the exam through coverage of techniques for applying the new scoring rules, information on the latest classification definitions (ICSD-3), tips for passing the exam, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Religion (and spirituality) is very much alive and shapes the cultural values and aspirations of psychiatrist and patient alike, as does the choice of not identifying with a particular faith. Patients bring their beliefs and convictions into the doctor-patient relationship. The challenge for mental health professionals, whatever their own world view, is to develop and refine their vocabularies such that they truly understand what is communicated to them by their patients. "Religion and Psychiatry" provides psychiatrists with a framework for this understanding and highlights the importance of religion and spirituality in mental well-being.

This book aims to inform and explain, as well as to be thought provoking and even controversial. Patiently and thoroughly, the authors consider why and how, when and where religion (and spirituality) are at stake in the life of psychiatric patients. The interface between psychiatry and religion is explored at different levels, varying from daily clinical practice to conceptual fieldwork. The book covers phenomenology, epidemiology, research data, explanatory models and theories. It also reviews the development of DSM V and its awareness of the importance of religion and spirituality in mental health.

What can religious traditions learn from each other to assist the patient? "Religion and Psychiatry" discusses this, as well as the neurological basis of religious experiences. It describes training programmes that successfully incorporate aspects of religion and demonstrates how different religious and spiritual traditions can be brought together to improve psychiatric training and daily practice.Describes the relationship of the main world religions with psychiatryConsiders training, policy and service deliveryProvides powerful support for more effective partnerships between psychiatry and religion in day to day clinical care

This is the first time that so many psychiatrists, psychologists and theologians from all parts of the world and from so many different religious and spiritual backgrounds have worked together to produce a book like this one. In that sense, it truly is a World Psychiatric Association publication.

"Religion and Psychiatry" is recommended reading for residents in psychiatry, postgraduates in theology, psychology and psychology of religion, researchers in psychiatric epidemiology and trans-cultural psychiatry, as well as professionals in theology, psychiatry and psychology of religion

Approximately 70 million people in the United States are affected by a sleep problem. About 40 million Americans suffer from chronic sleep disorders, and an additional 20-30 million are affected by intermittent sleep-related problems. However, an overwhelming majority of sleep disorders remain undiagnosed and untreated. Some of the most common ones are insomnia, restless legs syndrome, parasomnias, circadian rhythm disorders, excessive daytime sleepiness, night terrors, sleep apnea, periodic limb movement disorder, and narcolepsy. Long standing sleep disturbances can lead to non-productive lifestyles, poor work performance, weight gain, difficulty with concentration, and social avoidance. Some disorders, like sleep apnea, can lead to even more serious problems such as high blood pressure, heart attack, and stroke. Therefore, there is an urgent need for this introduction to the subject of sleep disorders. Chapters include information on symptoms and problems that signal a possible sleep disorder, descriptions of sleep loss effects and their demographics, definitions of common sleep disorders, explanations of various medical and psychological tests for sleep disorder diagnosis, essential medical treatments, guided intervention to change thinking about sleep and related health habits, alternative interventions, follow-up and maintenance issues, and behavioral changes. Appendices include a list of accredited sleep laboratories and resources, suggested readings, and suggested exercises and activities.

This is an analysis of the issues and strategies associated with national health care. The work examines legislation pending in the U.S. Congress, proposals by academic institutions and business and industry associations, the law and legislation underlying the existing system, and critical factors contributing to the existing health care crisis. Topics include the uninsured and underinsured, impaired risks and risk pooling, "pay or play" employer mandates, "universal" health care plans, and the so-called "market reforms." The study concludes with a proposal for a national health care plan that provides a package of "basic" benefits to all Americans, without regard to their work status.

""Children of Substance-Abusing Parents: Dynamics and Treatment"" is a necessary reference for all mental health professionals and students who need to understand and treat this population. It offers an invaluable look at treatment options and programmatic interventions across the life span and fills an important gap in the current literature. The contributors include a wide range of experts who provide up-to-date evidence-based clinical and programmatic strategies for working with children of alcohol and other substance-abusing parents of any age and in almost any practice setting.

This highly recommended book is a valuable resource for all practitioners and students concerned about this very large, but often hidden group of individuals and families."

From the Foreword by Sis Wenger
President/CEO
National Association for Children of Alcoholics

Parental drug abuse and alcoholism have an enormously detrimental impact on children and adolescents. Children whose parents suffer from drug abuse or alcoholism often face multiple physical, mental, and behavioral issues. They are at a greater risk for depression, anxiety, low self esteem, and addiction, and also are known to have poor school attendance, difficulty concentrating, and lower IQ scores.

This book offers health care practitioners proactive programs and innovative strategies to use with this vulnerable population. Taking a comprehensive, life course approach, the authors discuss the implications and interventions at the prenatal stage, through childhood, adolescence, young adulthood, and adulthood. With this book, social workers and health care practitioners can help assess and intervene with children of substance abusing parents.Key topics:

• Dynamics in families with substance abusing parents and treatment implications
• Issues across the life span of children of substance abusing parents
• Prevention and early intervention programs for pregnant women who abuse substances
• Programs for young children, adolescents, college students, and children with incarcerated parents

This book combines historical biography with a focus on the role of the practitioner in the folk health-care system, and ethnobotany, including a description of the active ingredients of the herbs used in African American herbal medicine. The contributions of European Colonial, American Indian, and African practices to the development of contemporary African American folk medicine are discussed. In addition to showing John Lee's approach to folk medicine, the volume provides descriptions and illustrations of the main herbs used. Folk Wisdom and Mother Wit provides a basic historical framework and background to the continuing viability of a folk medical system based on a pluralism combining biomedicine and traditional health care. As such, it will be of value to scholars and students of medical anthropology as well as Black Studies.