Catheter Ablation of Atrial Fibrillation
Edited by

Etienne Aliot, MD, FESC, FACC, FHRS Chief of Cardiology, Hopital Central, University of Nancy, France
Michel Haissaguerre, MD Chief of Electrophysiology, Hopital Cardiologique du Haut-Leveque, France
Warren M. Jackman, MD Chief of Electrophysiology, University of Oklahoma Health Science Center, USA

In this text, internationally recognized authors explore and explain the advances in basic and clinical electrophysiology that have had the greatest impact on catheter ablation of atrial fibrillation (AF).

Designed to assist in patient care, stimulate research projects, and continue the remarkable advances in catheter ablation of AF, the book covers:
the fundamental concepts of AF, origin of signals, computer simulation, and updated reviews of ablation tools
the present practical approaches to the ablation of specific targets in the fibrillating atria, including pulmonary veins, atrial neural network, fragmented electrograms, and linear lesions, as well as the strategies in paroxysmal or chronic AF or facing left atrial tachycardias
the special challenge of heart failure patients, the impact of ablation on mortality, atrial mechanical function, and lessons from surgical AF ablation

Richly illustrated by numerous high-quality images, Catheter Ablation of Atrial Fibrillation will help every member of the patient care team.

The proliferation of radioactive materials in industry, in diagnostic and therapeutic medicine, in scientific and medical research, in the military, and as a source of energy has increased the likelihood of accidental exposure to ionizing radiation. Further, the number of individuals exposed in accidents, such as Chernobyl, U. S. S. R.; Goiania, Brazil; and San Salvador, El Salvador, underscores the potential for large-scale radiation accidents. Because of these accidents, health care providers have found themselves treating patients with acute radiation injuries and subsequent complications. Often the radiation injuries are combined with burns or other trauma and the infectious and immune complications associated with such injuries. The treatment of victims of these accidents has provided important information about the medical management of radiation casualties. However, development of techniques to improve the diagnosis and treatment of radiation injuries, to collect follow up data on survivors, and to determine the long-term effects of uncontrolled radiation exposure must continue. The Armed Forces Radiobiology Research Institute, Bethesda, Maryland, and its Medical Radiobiology Advisory Team sponsored the First Consensus Development Conference on the Treatment of Radiation Injuries in Washington, DC, on May 10-13, 1989. The proceedings of the conference are presented in this volume, which we hope will serve as a reference for clinicians and basic research scientists who require knowledge of the latest developments in the diagnosis and treatment of radiation injuries. This conference was designed specifically to address the areas of hematopoietic injury, infectious complications, and combined injury."

This practical guide is the ideal tool for the busy practitioner or speech and language therapist to provide an effective, meaningful, and contextualised approach to language development using picture books. Drawing from up-to-date, evidence-based research, each chapter shows you how to get the most out of picture books to support language development, with a focus on the range of opportunities that reading aloud can bring. The guide offers a complete package to promote speech, language, and early literacy, and to enrich language comprehension, vocabulary, phonological awareness, and oral language – all by using books to provide a context for meaningful language learning. The resource also includes advice on how to develop intervention goals and outcome measures for reading aloud, with practical suggestions covering topics from creating a reading routine and book nooks, to encouraging reluctant readers and reading aloud challenges. Language skills are essential for academic, social and communication success and this reading aloud resource will be valuable reading for early year educators, primary teachers, and speech and language therapists working with young children aged 0-7.

This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for submission to both agencies. It also provides practical study designs and approaches that can be used to meet international requirements. Covering the full scope of non-clinical testing, regulations, models, practice, and relation to clinical trials, this text offers a comprehensive and up-to-date resource.

This Open Access volume provides a comprehensive overview of the latest tools available to scientists to study the many facets of whole-body regeneration (WBR). The chapters in this book are organized into six parts. Part One provides a historical overview on the study of the WBR phenomena focusing on the primary challenges of this research. Parts Two and Three explore a series of non-vertebrate zoological contexts that provide experimental models for WBR, showing how they can be approached with cellular tools. Parts Four, Five, and Six discuss the future advancements of WBR, reporting about the cutting-edge techniques in genetics and omics used to dissect the underlying mechanisms of WBR, and systems biology approaches to reach a synthetic view of WBR. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Whole-Body Regeneration: Methods and Protocols is a valuable resource for scientists and researchers who want to learn more about this important and developing field.

An intriguing look at the history of alcoholism and its dramatic effects, from the first fermented grape to current advances in genetic research. Alcoholism tells the story of a disease familiar to many yet not well understood. It is the first "biography" of alcohol abuse that gauges its devastating effects on the body, the family, the economy, and the community. Alcoholism provides the latest understanding of the disease as a behavioral dysfunction and a biological condition. Coverage includes the origins of alcohol and the discovery of alcoholism as a medical disease; the biology of alcoholism and its effects on the body; and current diagnostic and treatment methods for alcoholism. In addition, the book explores the effects on society of such alcoholism-related problems as domestic abuse, fetal alcohol syndrome, drunk driving, and suicide, as well as promising new directions in alcoholism research, awareness, treatment, and prevention.

Essential Paediatrics and Child Health ist ein praktischer Leitfaden mit umfassenden Informationen zu Kinderkrankheiten. Schritt-fur-Schritt-Anleitungen unterstutzen bei der Bewertung von Symptomen, Anamnese, Untersuchung und Diagnose. Hinzu kommen Leitfaden fur Management und Behandlung, Patientenaufklarung, Nachsorge und Prognose. Die komplett uberarbeitete Neuauflage dieses Klassikers bietet eine Fulle von Farbfotos, einzigartige und innovative Lernansatze und ist ein Muss fur Studenten der Medizin und Assistenzarzte. - Kinderkrankheiten werden zum schnellen Nachschlagen in systembezogenen Kapiteln vorgestellt. Die Symptome der wichtigsten Erkrankungen und Behinderungen im Kindesalter werden ausfuhrlich erlautert. - Verbindet aktuelle Informationen zu den jungsten Erkenntnissen aus Forschung und Klinikalltag mit Kernkompetenzen, die in dem Fachgebiet von Studenten erwartet werden. - Diagramme, Tabellen, Hinweiskastchen und Informationen auf einen Blick, Verweise auf Richtlinien und Zusammenfassungen erleichtern das Selbststudium. - Eigene Kapitel fassen die Erfahrungen von Studierenden zusammen, ermoeglichen die Selbstuberprufung des Gelernten und bieten Hilfestellung fur Praktika auf Kinderstationen, die Prufungsvorbereitung und wichtige Examina. - Eine neue Einfuhrung beschaftigt sich mit den Perspektiven der Padiatrie und gibt Handreichungen fur den gelungenen Einstieg. Neue Inhalte zu Kommunikationsstrategien, nationalen Richtlinien, Bildgebungsverfahren, Genetik und Epigenetik, Medikamentengabe bei Kindern, den jungsten Fortschritten in Diagnostik und Behandlung und viele weitere Themen runden dieses Lehrbuch ab. - Begleitende Website mit Videos zu Untersuchungsverfahren, interaktiven Patientenszenarios und Multiple-Choice-Fragen. Essential Paediatrics and Child Health ist der perfekte Begleiter fur Studenten der Medizin und Assistenzarzte.

Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the thirteenth volume of a continuing series.

Ringing in your ears isn't fun. But as people age and begin to lose hearing, the chances of tinnitus increase. The Tinnitus Alleviation Therapy (TAT) was devised by Maria Holl to help activate the patient's self-healing powers through a unique synthesis of psychotherapy, self-massage and her knowledge of ancient Chinese medicine that activates the body's energy system or chi. The series of 12 simple TAT lessons help direct chi through the body's energy channels and align the body with the earth.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature's longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 16th volume of a continuing series. Chapter "Epithelial Stem Cells: Making, Shaping and Breaking the Niche" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This work provides an evenhanded and authoritative overview of vaping and its impact on American culture and public health, especially among younger Americans. The 21st Century Turning Points series is a one-stop resource for understanding the people and events changing America today. This volume is devoted to the rapid rise of vaping across the nation, especially among young people. This trend has prompted fierce debate in communities across the country, with some people heralding "e-cigarettes" and other vaping devices as valuable smoking cessation tools and others condemning them for being unhealthy in their own right—and a gateway to future cigarette consumption. The Vaping Controversy describes the key events and people that provided the foundation for the rise of e-cigarettes and vaping, from governmental and medical efforts to reduce traditional cigarette smoking to the emergence and rapid spread of an entire industry devoted to selling vaping devices and accessories. This volume also explores how vaping has influenced youth culture and high school life, its impact on "old school" tobacco companies, and the increasingly visible partisan divide in attitudes about the public health impact of vaping.

Struggling to help someone you love as they battle an eating disorder? This book will arm you with the knowledge, understanding and skills you need to be able to help your loved one towards recovery. Psychologist and eating disorder specialist Dr Pamela Macdonald has been working with carers for over a decade. Here, she uses the established New Maudsley Approach, an evidence-based therapy toolkit which equips carers with the communication skills they need to best help their loved one. Dr Macdonald has personal experience of the effects that an eating disorder can have on the entire family and strongly believes that carers and parents are a crucial element to the recovery process.

This practical guide is the ideal tool for the busy practitioner or speech and language therapist to provide an effective, meaningful, and contextualised approach to language development using picture books. Drawing from up-to-date, evidence-based research, each chapter shows you how to get the most out of picture books to support language development, with a focus on the range of opportunities that reading aloud can bring. The guide offers a complete package to promote speech, language, and early literacy, and to enrich language comprehension, vocabulary, phonological awareness, and oral language – all by using books to provide a context for meaningful language learning. The resource also includes advice on how to develop intervention goals and outcome measures for reading aloud, with practical suggestions covering topics from creating a reading routine and book nooks, to encouraging reluctant readers and reading aloud challenges. Language skills are essential for academic, social and communication success and this reading aloud resource will be valuable reading for early year educators, primary teachers, and speech and language therapists working with young children aged 0-7.

• Offers practical guidance and insight that is based on theoretical knowledge about the process of diagnosing speech and language related needs • Includes a range of real-life case study examples as well as examples of diagnostical tests and materials • Includes example activities and exercises that can be used with children • Addresses a range of problems that can affect children including speech therapy, literacy, reading and writing and fine motor skills

Attachment theory-based treatments including depth psychology, somatic psychology, holistic therapy, and Eye Movement Desensitization and Reprocessing (EMDR) are becoming even more popular and desired by clinicians, health systems, and the patients they care for. Up until recently, cognitive behavioral therapy and medication management were the mainstays for trauma-informed care, although we are witnessing a demand for a more somatic, holistic, and, therefore, deeper level of treatment to target attachment injury and change/re-write the trauma narrative. This book provides the response and tools to meet this current need. Due to the pandemic, lockdowns, and significant changes in our stability, the economy, sense of belonging, and community, there is a heightened level of triggering which has resulted in multifactorial trauma responses. The devastating traumatic impact spans nations, ages, and socioeconomic statuses. Unfortunately, domestic violence, child abuse, substance use, medical trauma, self-injury, suicide, and violence turned outwards have all increased significantly in the past two years. This workbook focuses on the healing journey of the trauma survivor, utilizing easy-to-use methodologies for long-lasting effects. It includes various exercises, writing prompts, coping mechanisms, and soothing techniques with the intention of allowing the person to create an individualized experience. This empowers the person to go in the order they choose, experiment with different techniques from different modalities, and find the ones that meet their needs the best. The authors also address generational trauma, societal trauma, and trauma at the family and individual levels, and their work can be used in conjunction with a clinical treatment plan or by the end user. Re-Write: A Trauma Workbook of Creative Writing and Recovery in Our New Normal employs practical strategies using evidence-based methodologies with psychological theory within a human-centered design framework.

Attachment theory-based treatments including depth psychology, somatic psychology, holistic therapy, and Eye Movement Desensitization and Reprocessing (EMDR) are becoming even more popular and desired by clinicians, health systems, and the patients they care for. Up until recently, cognitive behavioral therapy and medication management were the mainstays for trauma-informed care, although we are witnessing a demand for a more somatic, holistic, and, therefore, deeper level of treatment to target attachment injury and change/re-write the trauma narrative. This book provides the response and tools to meet this current need. Due to the pandemic, lockdowns, and significant changes in our stability, the economy, sense of belonging, and community, there is a heightened level of triggering which has resulted in multifactorial trauma responses. The devastating traumatic impact spans nations, ages, and socioeconomic statuses. Unfortunately, domestic violence, child abuse, substance use, medical trauma, self-injury, suicide, and violence turned outwards have all increased significantly in the past two years. This workbook focuses on the healing journey of the trauma survivor, utilizing easy-to-use methodologies for long-lasting effects. It includes various exercises, writing prompts, coping mechanisms, and soothing techniques with the intention of allowing the person to create an individualized experience. This empowers the person to go in the order they choose, experiment with different techniques from different modalities, and find the ones that meet their needs the best. The authors also address generational trauma, societal trauma, and trauma at the family and individual levels, and their work can be used in conjunction with a clinical treatment plan or by the end user. Re-Write: A Trauma Workbook of Creative Writing and Recovery in Our New Normal employs practical strategies using evidence-based methodologies with psychological theory within a human-centered design framework.

Addiction is a national mental and medical health crisis, responsible for untold costs to our society and severe suffering to innumerable people. Yet addiction treatment, as it is now practiced, fails half the time. The current treatment approach has changed little in the last 80 years and is a hodgepodge of often-shady treatment approaches. This book presents a radically different addiction treatment paradigm, based on science, evidence and best practices, and has a success rate approaching 100% when followed closely. This model will profoundly upend the current addiction treatment industry. Nearly every addict lives in a social system, a family, workplace or community that enables and supports, often unconsciously, the addict's addiction. Instead of the current addict-focused approach, this model extends treatment to the entire support system, starting treatment with the concerned family members. This model also proposes a single provider, the family recovery therapist, who oversees and manages treatment for the addict and the family from the first phone call through the first year of continuous sobriety. This book offers simple recommendations to both addiction treatment providers and family members impacted by this brain disease. It serves as a beacon of hope for families impacted by addiction.

This book focuses on Somatic Movement Dance Therapy and the importance of self-regulation and co-regulation.  The chapters attend to self-regulating different tissues through movement, breath, sound and the imagination. Throughout the book the author shares processes and practices that support participants to balance their living tissues, moving from sympathetic arousal into parasympathetic ease and release. The study of the autonomic nervous system and how to innervate the parasympathetic through breath awareness, heart-sensing and intero-ception is the central through-line in the book. Uniquely, Williamson attends to the anatomical and physiological complexity underlying the apparent simplicity of somatic movement dance practice. How to sense-perceive and move with attuned awareness of specific body tissues, such the skeletal-muscular and craniosacral system invites the reader into a deep anatomical and physiological excavation of self-regulation. The interconnectivity of fascia, and the importance of cardio-ception, breath awareness and gravity lie at the heart of this book. Sensory-perceptual awareness of the heart is foregrounded as the most important ingredient in the efficacy of practice, as well as gravi-ception, soft-tissue-rolling and fascial unwinding. Includes a collective foreword from Sarah Whatley, Daniel Deslauriers, Celeste Snowber and Karin Rugman  This is a must-read practice-as-research book, for under- and postgraduate students, researchers and educators and especially important for practitioners who feel the weight and condensation of the mechanistic paradigm.

Doctors, nurses, and other caregivers often know what people with Alzheimer's disease or Asperger's 'sound like' - that is they recognise patterns in people's discourse, from sounds and silences, to words, sentences and story structures. Such discourse patterns may inform their clinical judgements and affect the decisions they make. However, this knowledge is often tacit, like recognising a regional accent without knowing how to describe its features. This is the first book to present models for comprehensively describing discourse specifically in clinical contexts and to illustrate models with detailed analyses of discourse patterns associated with degenerative (Alzheimer's) and developmental (autism spectrum) disorders. The book is aimed not only at advanced students and researchers in linguistics, discourse analysis, speech pathology and clinical psychology but also at researchers, clinicians and caregivers for whom explicit knowledge of discourse patterns might be helpful.