Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more.

Bioinspiration is recognized by the World Health Organization as having great promise in transforming and democratizing health systems while improving the quality, safety, and efficiency of standard healthcare in order to offer patients the tremendous opportunity to take charge of their own health. This phenomenon can enable great medical breakthroughs by helping healthcare providers improve patient care, make accurate diagnoses, optimize treatment protocols, and more. Unfortunately, the consequences can be serious if those who finance, design, regulate, or use artificial intelligence (AI) technologies for health do not prioritize ethical principles and obligations in terms of human rights and preservation of the private life. Advanced Bioinspiration Methods for Healthcare Standards, Policies, and Reform is the fruit of the fusion of AI and medicine, which brings together the latest empirical research findings in the areas of AI, bioinspiration, law, ethics, and medicine. It assists professionals in optimizing the potential benefits of AI models and bioinspired algorithms in health issues while mitigating potential dangers by examining the complex issues and innovative solutions that are linked to healthcare standards, policies, and reform. Covering topics such as genetic algorithms, health surveillance cameras, and hybrid classification algorithms, this premier reference source is an excellent resource for AI specialists, hospital administrators, health professionals, healthcare scientists, students and educators of higher education, government officials, researchers, and academicians.

Very few topics in global health have been as controversial as primary health care. In this book the authors explain what it takes to reimagine primary health care in the 21st century, an era of increased rapidly changing health care needs, population expectations, availability of financial and human resources, and digital technology.

Wastewater-based Epidemiology for the Assessment of Human Exposure to Environmental Pollutants discusses wastewater-based epidemiology (WBE) and its use in risk assessment and monitoring of human exposure to hazardous pollutants and pathogens. The book explores the health impacts of organic and inorganic pollutants from pesticides, heavy metals, pharmaceuticals, phthalates, personal care products, and endocrine disruptors in the wastewater environment. The book examines the application of wastewater-based epidemiology in determining health risk and exposure to infectious diseases caused by viruses, such as SARS-CoV-2, parasites, and bacteria. Other topics include detection techniques, sampling techniques, analytical methods, biomarkers, and the use of biosensors in wastewater-based epidemiology studies.

Complementary Strategies to Study Virus Structure and Function, Volume 104, the latest release in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on X-ray structures from crystals of viral proteins grown in cellula, NMR and SAXS to study protein dynamics and natively disordered viral proteins, Mass spectrometry to study virus particle assembly, Atomic force microscopy to study virus particles, Non-enveloped viruses and interactions with antibodies, Non-enveloped viruses and their mechanism of entry into cells, Structures of enveloped virions by electron cryo-microscopy and cryo-tomography, and many other interesting topics.

The world of medical technologies is undergoing a sea of change in the domain of consumer culture. Having a grasp on what appeals to consumers and how consumers are making purchasing decisions is essential to the success of any organization that thrives by offering a product or service. As such, it is vital to examine the consumer-centered aspects of medical technological developments that have a patient-centered focus and allow patients to take part in their own personal health and wellness. Consumer-Driven Technologies in Healthcare: Breakthroughs in Research and Practice is a critical source of academic knowledge on the use of smartphones and other technological devices for cancer therapy, fitness and wellness, chronic disease monitoring, and other areas. The tracking of these items using technology has allowed consumers to take control of their own healthcare. Highlighting a range of pertinent topics such as clinical decision support systems, patient engagement, and electronic health records, this publication is an ideal reference source for doctors, nurse practitioners, hospital administrators, medical professionals, IT professionals, academicians, and researchers interested in advancing medical practice through technology.

Toxicity and Toxicodynamics in Drug Research, Volume 1: Essentials in Pharmatoxicology provides an overview on the essentials of toxicology, risk assessment, and the mechanisms that might occur as the result of toxicological and the potentially harmful action and response of pharmaceuticals. Volume 1: Essentials in Pharmatoxicology opens with an introduction to pharmatoxicology and toxicology in drug research. It covers topics such as the types of cellular responses to chemical toxicants, the mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology. The book also covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as expounds on the role of regulatory agencies in toxicity studies. It covers the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. There is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

This book provides a definitive and comprehensive contribution to the expanding body of research related to sport/physical culture and the COVID-19 global pandemic. By examining the generative complexities that simultaneously link and shape sport/physical culture and COVID, the book develops a collection of multi-faceted readings. The anthology is framed by an ontological understanding prefigured on relationality, liminality, and perpetual becoming. The contributions theoretically, methodologically and representationally explore COVID-sport assemblages as a dynamic and diverse "ad hoc grouping"of interpenetrating affecting elements, encompassing material and expressive forms, human and non-human, animate and inanimate matter. The book will be of interest to advanced undergraduate and students and scholars of kinesiology, sociology of sport, critical studies of the body, physical education, sport and social issues, public health, physical cultural studies, sociology, foreign policy studies, and international studies.