This volume details protocols that broadly cover many aspects of basic and translational research on Borrelia burgdorferi. Chapters guide readers through epidemiology and ecology, cultivation, cell structure, physiology, genomics and transcriptomics, proteomics, animal infection, pathogenesis and host responses, and vaccines. These essential protocols incorporate the most recent, practical, and innovative research tools aiding new and experienced researchers in their studies involving the biology, pathogenesis, and prevention of B. burgdorferi infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Borrelia burgdorferi: Methods and Protocols aims to ensure successful results in the further study of this vital field of biomedical research.

This issue of Medical Clinics, guest edited by Drs. Marc Shalaby and Edward Bollard, is devoted to Quality Patient Care: Making Evidence-Based, High Value Choices. Articles in this issue include: Cardiovascular testing in asymptomatic patients: carotid duplex, cardiac stress testing, screen for PVD; Utility of echocardiogram in the evaluation of heart murmurs; Evidenced-based recommendations for the evaluation of palpitations in the primary care setting; Radiologic evaluation of common orthopedic complaints: low back pain, non-traumatic knee/shoulder/hip pain, and ankle injuries; Indications and usefulness of common injections for non-traumatic orthopedic complaints - shoulder, trochanteric bursa, epidural injections, tennis elbow, and knee; The evidence-based evaluation of chronic cough; Evaluation of uncomplicated headache; Evaluation of syncope; Pre-operative assessment: Cataract surgery, pre-operative EKG testing, screening for cardiopulmonary disease, urinalysis, coagulation studies, other lab assessments; The approach to occult GI bleed; The role of EGD surveillance for patients with Barrett's esophagus; The evidence-based evaluation of iron deficiency anemia; Cancer screening in the elderly; Utilization and safety of common over the counter dietary/nutritional supplements, herbal agents and homeopathic compounds for disease prevention; Utilization of oxygen for the patient with dyspnea; IV fluids, enteral or parenteral nutrition; and Symptom control at the end of life.

This handbook fills major gaps in the child and adolescent mental health literature by focusing on the unique challenges and resiliencies of African American youth. It combines a cultural perspective on the needs of the population with best-practice approaches to interventions. Chapters provide expert insights into sociocultural factors that influence mental health, the prevalence of particular disorders among African American adolescents, ethnically salient assessment and diagnostic methods, and the evidence base for specific models. The information presented in this handbook helps bring the field closer to critical goals: increasing access to treatment, preventing misdiagnosis and over hospitalization, and reducing and ending disparities in research and care. Topics featured in this book include: The epidemiology of mental disorders in African American youth. Culturally relevant diagnosis and assessment of mental illness. Uses of dialectical behavioral therapy and interpersonal therapy. Community approaches to promoting positive mental health and psychosocial well-being. Culturally relevant psychopharmacology. Future directions for the field. The Handbook of Mental Health in African American Youth is a must-have resource for researchers, professors, and graduate students as well as clinicians and related professionals in child and school psychology, public health, family studies, child and adolescent psychiatry, family medicine, and social work.

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

This is the first book to address public health issues in traditional, complementary and alternative medicine (TCAM). It presents state-of-the-art reviews of TCAM research in a range of priority public health areas such as malaria and HIV and in such common ailments as skin conditions and orthopedic injury in developing countries. Contributions analyze policy trends in areas such as financing of TCAM and education and training in this field as well as selected case studies of model TCAM projects. Important chapters on research methodology, ethical and safety issues, and intellectual property rights pertaining to traditional medicine are also presented.Public financing for TCAM is a test of the commitment of governments, and the book includes an analysis from the World Health Organization's (WHO) Global Atlas data of the worldwide trends in this area. With safety concerns foremost in the minds of both policy makers and the public, the book offers a global overview of policy and legislative trends in this field as well as an important set of guidelines for pharmacovigilance and TCAM products.

In 1950, a diagnosis of cancer was all but a death sentence. Mortality rates only got worse, and as late as 1986, an article in the New England Journal of Medicine lamented: We are losing the war against cancer." Cancer is one of humankind's oldest and most persistent enemies it has been called the existential disease.But we are now entering a new, and more positive, phase in this long campaign. While cancer has not been cured,and a cure may elude us for a long time yet,there has been a revolution in our understanding of its nature. Years of brilliant science have revealed how this individualistic disease seizes control of the foundations of life,our genes,and produces guerrilla cells that can attack and elude treatments. Armed with those insights, scientists have been developing more effective weapons and producing better outcomes for patients. Paul A. Marks, MD, has been a leader in these efforts to finally control this devastating disease.Marks helped establish the strategy for the war on cancer" in 1971 as a researcher and member of President Nixon's cancer panel. As the president and chief executive officer for nineteen years at the world's pre-eminent cancer hospital, the Memorial Sloan-Kettering Cancer centre, he was instrumental in ending the years of futility. He also developed better therapies that promise a new era of cancer containment. Some cancers, like childhood leukemia and non-Hodgkin's lymphoma, that were once deadly conditions, are now survivable,even curable. New steps in prevention and early diagnosis are giving patients even more hope. On the Cancer Frontier is Marks' account of the transformation in our understanding of cancer and why there is growing optimism in our ability to stop it.

This third and final volume of Richard Jessor's collected works explores the central role of the social context in the formulation and application of Problem Behavior Theory. It discusses the effect of the social environment, especially the social context of disadvantage and limited opportunity, on adolescent behavior, health, and development. The book examines the application of the theory in social contexts as diverse as the inner cities of the United States; the slums of Nairobi, Kenya; and the urban settings of Beijing, China. It also provides insight into how adolescents and young adults manage to "succeed", despite disadvantage, limited opportunity, and even dangers in their everyday life settings. It illuminates how these youth manage to stay on track in school, avoid unintended pregnancy and dropout, keep clear of the criminal justice system, and remain uninvolved in heavy drug use. In addition, the book discusses the conceptual and methodological issues entailed in engaging the social context, including the role of subjectivity and meaning in an objective behavioral science; the contribution of the perceived environment in determining behavior; the continuity that characterizes adolescent growth and development; the necessity for a social-psychological level of analysis that avoids reductionism; the importance of a framework that engages the larger social environment; and the advantage of adhering to systematic theory for the explanatory generality it yields. Topics featured in this volume include: Home-leaving and its occurrence among youth in impoverished circumstances. The continuity of adolescent developmental change. The impact of neighborhood disadvantage on successful adolescent development. Successful adolescence in the slums of Nairobi, Kenya. Explaining both behavior and development in the language of social psychology. Problem Behavior Theory and the Social Context is a must-have resource for researchers, professors, clinicians, and related professionals as well as graduate students in sociology, social and developmental psychology, criminology/criminal justice, public health, and allied disciplines.

This book offers a unique examination of how violence is situationally induced and reproduced for those inmates living with HIV in a US State prison system. Imprisonment is the only space where Americans have a constitutional right to healthcare but findings from this research suggest that accessing this care and associated welfare benefits requires some degree of violence. This book documents how HIV-positive inmates went about achieving agency through harm to their bodies and social standing to improve their health and wellbeing, in prison and upon re-entry to the community. It focusses on ethnographic research which was carried out in seven penal facilities in New England and comprises of accounts from inmates, prison staff, healthcare providers, ex-offenders, and community social workers. This book speaks to academics interested in prisons, violence, health, and ethnographic research, and to policy makers.

This edited volume brings together some of the most prominent scholars in the fields of theoretical, critical, and political psychology to examine crisis phenomena. The book investigates the role of psychology as a science in times of crisis, discusses how socio-political change affects the discipline and profession, and renders psychological interventions as forms of political action. The authors examine how notions of crisis and the interpretation of crisis scenarios are heavily intertwined with governmental and state interests. Seeking to disentangle individual subjectivity, subjectification, and science as forms of politics, the volume works toward an explicit goal to decolonize psychology. The chapters elaborate on the importance of the psychological sciences in times of crisis and the role of psychologists as practitioners. Ultimately, the diverse contributions underline the connection of scientific theory, practice, and politics. Interdisciplinary in scope and wide-ranging in its perspectives, this timely work will appeal to students and scholars of theoretical and political psychology, critical psychology, and cultural studies.

Without Samuel J. Crumbine and his Kansas Department of Health, diseases festering in water sources, food, and the common towel at the turn of the 20th century would have caused thousands of deaths in the United States and beyond. Crumbine and his associates paved the way to better treatment of tuberculosis and other common diseases. This well-written account leads the reader down a path of crucial medical advancements. Samuel J. Crumbine was a medical educator without peer, who used his department of health to disseminate the latest developments he and others throughout the world were achieving in public health. He found it necessary to propagandize a skeptical and sometimes hostile public to accept the germ theory, the idea that invisible microbes were making them ill and that they should clean up their environment and their food and water sources. He had to convince the public to rely on modern medicine, not snake oil and other miracle cures for a healthy living. R. Alton Lee's historical account might offer insight in today's threat of Bird Flu and other recent medical threats for any reader.

This pivot considers the dissemination of public health terms in Chinese scientific research and printed media. Bringing together quantitative and qualitative analysis from corpus linguistics, translation studies, contrastive linguistics to bear on the study of specialised public health translation, it provides key insights into the translation of key public health policy materials produced by authoritative international health agencies like the World Health Organisation (WHO). The study of the acceptance, assimilation and update of translated health risk terms is embedded within corpus translation studies, one of the most dynamic areas of applied translation studies. This study deploys large-scale data bases of scientific publications and printed media materials to trace and analyse the use of translated public health terms and linguistic synonyms by Chinese researchers and media. It also highlights the limits of research investment on critical public health topics such as health financial risks and considers worldwide concerns about the use of accurate and appropriate terminology in specialized fields of knowledge, and the implications for scholarly research, translator training and professional practice.

The Deep South has seen a 36 percent increase in AIDS cases while the rest of the nation has seen a 2 percent decline. Many of the underlying reasons for the disease's continued spread in the region-ignorance about HIV, reluctance to get tested, non-adherence to treatment protocols, resistance to behavioral changes-remain unaddressed by policymakers. In this extensively revised second edition, Kathryn Whetten and Brian Wells Pence present a rich discussion of twenty-five ethnographic life stories of people living with HIV in the South. Most importantly, they incorporate research from their recent quantitative study, "Coping with HIV/AIDS in the Southeast" (CHASE), which includes 611 HIV-positive patients from North Carolina, South Carolina, Georgia, Alabama, and Louisiana. This new edition continues to bring the participants' voices to life while highlighting how the CHASE study confirmed many of the themes that originally emerged from the life histories. This is the first cohesive compilation of up-to-date evidence on the unique and difficult aspects of living with HIV in the Deep South.

This informative text details the many changes in everyday life as the result of injury, illness, or aging affecting the brain. Experts across brain-related fields trace mechanisms of conditions such as Parkinson's disease, TBI, and dementia as they impact regions of the brain, and resulting cognitive, emotional, sensory, and motor impairments as they contribute to deficits in personal and social functioning. In addition to symptoms and behaviors associated with insults to the brain (and the extent to which the brain can adapt or self-repair), chapters provide cogent examples of how societal and cultural expectations can shape the context and experience of disability. The book's focus on everyday activities brings new clarity to diverse links between symptoms and diagnosis, brain and behavior. Included in the coverage: *The aging brain and changes in daily function. *Stroke: impact on life and daily function. *Traumatic brain injury (TBI) and the impact on daily life. *Everyday life with cancer. *Real-world impact of HIV-associated neurocognitive impairment. *Disability and public policy in America. *Living after brain changes, from the patient's perspective. Rich in empirical data and human insight, Changes in the Brain gives neuropsychologists, clinical psychologists, clinical social workers, and rehabilitation nurses a robust new understanding of the daily lives of patients, both in theory and in the real world.

This unique volume explores a growing collaboration between the sport and health sectors to deliver innovative public health interventions in the community. It explores the role of sport and sports settings as a vehicle for achieving health outcomes, as well as some of the practical and moral challenges presented by sport and public health partnerships working together. Twenty detailed examples illustrate the broad range of programs which have already been developed around the world, from across the spectrum of public health activity. Chapters include: * Time Out for Your Health: A sports-based health intervention approach with American football teams* Promoting Mental Wellbeing in Rugby League communities* Slum Soccer - female empowerment through football* Football 4 Peace* Sport as a post-disaster psychosocial intervention for children in Bam, Iran* Sex and Sport: An Australian rules football-based chlamydia screening initiative As well as showcasing what has been achieved in this exciting new field, Sports-based Health Interventions shares valuable advice and lessons learnt to inform the next generation of sports-based public health initiatives.

Presently, the healthcare industry is grappling with many challenges both nationally and globally, including escalating costs, a move to a preventative care environment and a technology savvy patient with high expectations. To accommodate the changing health demands of the current global population, public healthcare policy must undergo a critical analysis. Social, Economic, and Political Perspectives on Public Health Policy-Making provides an extensive and rich compilation of research on the role of public policy in the healthcare sector and how policy reform will impact the future of healthcare delivery and administration. This research-based publication is composed of chapters from various international experts in the healthcare sector, focusing on the areas of healthcare access, quality, and value in the 21st century. Government agencies, policymakers, healthcare professionals, hospital administrators, and graduate-level students studying within the fields of government and healthcare administration will find this publication to be an essential resource.

Rice is a vitally important staple food for almost half of the world's population. As the global population increases, the demands for rice are expected to remain high. Since the rice industry will remain sustainable for a long time, the production of rice by-products will remain high. Substantial evidence suggests that rice by-products such as rice husk, rice straw, broken rice, rice germ, rice bran, and brewers' rice may possess beneficial effects against oxidative stress and metabolic disorders. These beneficial effects have been linked to the phytochemicals present in rice by-products such as vitamin E, dietary fiber, -oryzanol, -aminobutyric acid (GABA), and phytosterols. Despite this evidence, the literature pertaining to rice by-products and its derived components has not well been compiled. To this end, Rice By-products: Phytochemicals and Food Products Application provides full coverage of issues pertaining to rice by-products, namely rice demands and rice by-products production, phytonutrients and antioxidant properties of rice by-products, potential health benefits, application in food products, and future prospects. By summarizing all the information in a lucid and comprehensive manner, authors provide a cohesive representation of the literature on the molecular mechanisms involved in the pharmacological effects of the bioactive components that present in rice by-products, as well as plausible means for the prevention of metabolic disorders for readers and allied stakeholders.

This book focuses on the food safety challenges in the vegetable industry from primary production to consumption. It describes existing and innovative quantitative methods that could be applied to the vegetable industry for food safety and quality, and suggests ways in which such methods can be applied for risk assessment. Examples of application of food safety objectives and other risk metrics for microbial risk management in the vegetable industry are presented. The work also introduces readers to new preservation and packaging methods, advanced oxidative processes (AOPs) for disinfection, product shelf-life determination methods, and rapid analytic methods for quality assessment based on chemometrics applications, thus providing a quantitative basis for the most important aspects concerning safety and quality in the vegetable sector.

A detailed guide to the design and evaluation of effective disaster learning programs Disaster Education, Communication and Engagement provides a much-needed evidence-based guide for designing effective disaster learning plans and programs that are tailored to local communities and their particular hazard risks. Drawing on the most recent research from disaster psychology, disaster sociology, and education psychology, as well as evaluations of disaster learning programs, the book contains practical guidance for putting in place a proven design framework. The book outlines the steps to take in order to tailor a disaster education, communication and engagement program and highlights illustrative examples of effective programs and activities from around the world. The author includes information on how to identify potential community learners and presents a methodology for understanding the at-risk community, its hazard risks, disaster risk reduction, and emergency management arrangements. Disaster Education, Communication and Engagement describes both country-wide campaigns and local disaster programs that involve community participation. This important resource: Presents a detailed framework to guide the design and evaluation of tailored disaster learning programs Includes information that links disaster resilience with sustainability and climate change learning Describes the 'disaster cycle' and reviews learning content and methods related to the cycle Explains effective ways to combine disaster education, disaster communications, and disaster-related engagement Contains material on using new technologies such as gamification, virtual reality, and social media Written for emergency managers, students of emergency management, and humanitarian courses, Disaster Education, Communication and Engagement is a hands-on guide filled with ideas and templates for designing and evaluating targeted disaster learning programs.

In this book Jo Maybin draws on rare access to the inner-workings of England's Department of Health to explore what kinds of knowledge civil servants use when developing policy, how they use it and why. Combining ethnographic data with insights from psychology, socio-linguistics, sociology and philosophy, she demonstrates how civil servants engage in a wide range of knowledge practices in the course of their daily work. These include sharing personal anecdotes, thrashing-out ideas in meetings and creating simplified representations of phenomena, as well as conducting cost-benefit analyses and commissioning academic research. Maybin analyzes the different functions that these various practices serve, from developing personal understandings of issues, to making complex social problems 'thinkable', and meeting the ever-present need to make policies 'happen'. In doing so, she develops an original theory of policy-making as the work of building connections between a policy in development and powerful ideas, people, and instruments, and reveals the 'policy know-how' required by civil servants to be effective in their jobs.

This book is the first to introduce applied behavioral, social, and health sciences researchers to a new analytic method, the time-varying effect model (TVEM). It details how TVEM may be used to advance research on developmental and dynamic processes by examining how associations between variables change across time. The book describes how TVEM is a direct and intuitive extension of standard linear regression; whereas standard linear regression coefficients are static estimates that do not change with time, TVEM coefficients are allowed to change as continuous functions of real time, including developmental age, historical time, time of day, days since an event, and so forth. The book introduces readers to new research questions that can be addressed by applying TVEM in their research. Readers gain the practical skills necessary for specifying a wide variety of time-varying effect models, including those with continuous, binary, and count outcomes. The book presents technical details of TVEM estimation and three novel empirical studies focused on developmental questions using TVEM to estimate age-varying effects, historical shifts in behavior and attitudes, and real-time changes across days relative to an event. The volume provides a walkthrough of the process for conducting each of these studies, presenting decisions that were made, and offering sufficient detail so that readers may embark on similar studies in their own research. The book concludes with comments about additional uses of TVEM in applied research as well as software considerations and future directions. Throughout the book, proper interpretation of the output provided by TVEM is emphasized. Time-Varying Effect Modeling for the Behavioral, Social, and Health Sciences is an essential resource for researchers, clinicians/practitioners as well as graduate students in developmental psychology, public health, statistics and methodology for the social, behavioral, developmental, and public health sciences.