Assisted Reproduction is a specialty undergoing rapid change as new technologies are introduced and new research challenges previous treatment options. This text examines a selection of controversial topics for both laboratory and clinical practice and tries to place them in perspective, so readers can understand how and why the current state of the question has come about and how future contributions to the debate should be measured. All physicians involved with the technologies concerned will learn from the expert contributions assembled here. CONTENTS: The use of ovarian markers * Use of molecular markers of endometrial receptivity * Use of GnRHa for triggering final oocyte maturation during ovarian stimulation cycles * Use of time-lapse embryo imaging in assisted reproductive technology practice * Use of cryopreservation for all embryos * Preimplantation genetic screening * The use of single embryo transfer * Use of luteal phase support * Measuring safety and efficiency in in vitro fertilization * To flush follicles during egg collection or not * Use of blastocyst culture * Use of mitochondrial donation * Controversies in recurrent implantation failure: From theory to practice * Fibroids: To remove or not? * Limitations of endometrioma surgery in in vitro fertilization: Possibilities of early disease control

With the fall in mortality from infectious diseases, the* impact of childhood cancer in the Western World has increased to become the second commonest cause of death in the age group 1-14 years, being surpassed only by accidents. However, even in those countries in which paediatric cancer is attracting increasing interest, the disease is relatively uncommon, and the number of cases seen by any one physician, even in a large general hospital, is often limited to one or two a year. The widely held view by parents and even by many doctors that cancer in childhood is usually untreatable and inevitably fatal is no longer tenable. With improvement in the therapeutic response or in the actual survival rates of children with such lesions as Wilms' tumour, brain tumours, rhabdomyosarcomas, Ewing's sarcoma, retinoblastoma, lym phoma and even leukaemia, there is a real hope of achieving a substantial reduction in the mortality of childhood cancer. Paediatric oncology is, in fact, providing a vigorous stimulus to the much wider field of cancer treatment and research, and is demonstrating the advantages of a multi-disciplinary cooperation in the management of this disease.

This textbook has its ongm in a longstanding international profes sional and personal relationship of the authors. The success of the German edition was a result of the interest of the German authors, Dr. K. Knorr and Dr. C. Lauritzen, in synthesizing basic and clinical information in a textbook, the size and scope of which are appropriate to the modern undergraduate medical student. A unique feature of the volume was the addition of American gynecological thinking by Dr. F. K. Beller, who spent 12 years at New York University before returning to Germany. The English edition, which is aimed at the American medical student, has enlisted the services of Dr. R. M. Wynn, whose academic career has been in the United States, although he is thoroughly familiar with principles and practices of German gynecology. The English edition is not merely a translation of the German text. Rather, it incorporates most of the material, but with judiciOUS deletions, additions, and substitutions it brings the teaching into the mainstream of American medical education. We acknowledge with gratitude the expert editional assistance of Dr. Henriette Knorr-Gartner. Dr. R. Schuh mann and Mr. H. Brandt of Springer-Verlag were responsible for the histological sketches. The late Dr. H. Roemer prepared the section on psychosomatic disorders; Dr. F. W. Ahnefeld assisted in the section on shock; and Dr. H. Breinl helped to prepare the chapter on anatomy in the German edition."

Major advances in genetics, immunology, and endocrinology have necessitated a new edition of this best-selling text. However, despite the advances, recurrent pregnancy loss presents a frustrating clinical problem. There is still disagreement about the number of pregnancy losses which warrant investigation and treatment and about which investigations should be performed. This third edition provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon, covering both basic scientific topics such as genetics and cytokines, and profiles major advances in immunology, endocrinology, and thrombotic mechanism. Clinical research is discussed, as is assessment of results when applying an evidence-based approach or a more personalised approach, which is now becoming possible due to advances in the diagnosis of cause. There are lively debates on the role of progestogens and immunotherapy, which remain controversial. Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynecologists seeking a comprehensive view of developments in the field.

Why is it that women suffer far more than men from insomnia? What is the connection between the hormonal changes that a woman undergoes during her lifetime, and difficulty in falling asleep? What is the effect of cell phones on sleep? Should women engage in sports before going to sleep? What do women primarily dream about? In which country do people sleep the most? How do depression and anxiety affect sleep? And why is it inadvisable to resort to a "little pill" to provide unworried sleep? This clear and readable book, illustrated with short quotations of poetry and prose about sleep and dreams, provides a glimpse into the wonderful mechanism of sleep, explains how correct treatment of sleep disturbances results from understanding their causes, and shows the right path to a pleasant and satisfying night's sleep; it will be of great interest for all women and clinicians dealing with female patients. In particular, because of the connection between sleep and hormones, problems with sleep have repercussions for women's reproductive life cycle. This pioneering text will therefore be of particular interest to gynecologists working in Reproductive Medicine.

Sexualit t und ihre St rungen haben in den letzten Jahrzehnten einen tief greifenden normativen Wandel erfahren. Dennoch herrscht ein Versorgungsnotstand in der Behandlung sexueller St rungen. Immer mehr Personen w nschen sich Beratung und therapeutische Hilfe. Manche rzte haben jedoch Probleme, sie darauf anzusprechen.

"Sexualst rungen" stellt Diagnostik, Beratung und Behandlung von sexuellen St rungen in den verschiedenen Lebensabschnitten praxisnah dar. Des Weiteren werden sexueller Missbrauch, geschlechtsspezifische Dysfunktionen, Fertilit tsst rungen und forensische Aspekte der Sexualit t thematisiert und neurobiologische Faktoren der Sexualit t diskutiert.

In writing this book I have attempted to follow the gen eral pattern of the lectures which I have given to pupil midwives at Worcester Royal Infirmary for the past 21 years. In hospital it has been possible to illustrate what I have had to discuss by reference to cases at present in the wards. This unfortunately is not possible to the same extent in a book, but I have no doubt that my readers will be able to apply the principles described to cases under their care. I am sure that this is a most helpful way of fixing in one's mind the information which is required not only for examination purposes but so much more importantly for the better understanding of the clinical problems with which one is faced, and for the purpose of bringing to them the best possible management. The chapter headings and the arrangement of the chapter content may be regarded as unorthodox, but I have presented the topics in the way in which they seem to me to arise in clinical practice. This, I hope, will make easier the understanding of all aspects of a problem. [ have tried to avoid duplication, and when a topic appears in more than one place, it does so in order to discuss its relevance in a differ ent context. Cross-references have been used throughout the text, in order to facilitate reference to the other facts of importance.

The provision of the best possible anesthetic care to the-greatest number of patients all over the world has always been the main goal of the World Federation of Societies of Anaesthesiologists. In addition to the establishment of Regional Anesthesiology Training Centers and the organization of Regional and World Congresses, the distribution of practical monographs on some important aspects of anesthesiology were considered important for the attainment of this objective. In 1968, on the occasion of the Fourth World Congress of Anesthesiology, held in London, a monograph on "Emergency Resuscitation", compiled by the Committee on Cardiopulmonary Resuscitation, chaired by Professor HENNING POULSEN, was made available to our membership. Subsequent ly, this excellent monograph was translated into Spanish, Russian, Ger man and French and to this date over 100,000 copies of it have been distributed to anesthesiologists and other interested physicians the world over. When looking for a suitable topic for a second monograph to commem orate the 1972 World Congress of Anesthesiology to be held in Kyoto this September, the subject of Obstetric Analgesia and Anesthesia was the first choice of almost everyone consulted. For reasons that are hard to condone, obstetric analgesia and anesthesia has often been the step child among the anesthetic subspecialties.

Parents of children born with mental or physical handicaps, tend to face the physician with questions about the origin of the abnormality concerned and the chance of having another child with the same condition. The physician then finds himself in a difficult situation since the causes of the majority of congenital abnormalities remain as yet unknown. In most cases he has to restrict himself to a mere enumeration of the signs and symptoms encountered or, at best, to a classification of the syndrome at hand. Efforts are frequently made to connect both the somatic aberrations and the mental deficiency with complications during the later stages of pregnancy, at the time of delivery or in the immediate postnatal period. However, a careful search for such items as abnormal dermatoglyphs, or 'degenerative stigmata', and, in particular, a post-mortem examination of the brain, often indicates that the handicap concerned should be ascribed to factors operating long before the time of birth. Theoretically, the causes of abnormalities present at birth can be listed as of a genetic, germinal or peristatic nature. During the past decades special attention has been paid to both genetic and peristatic factors. The purpose of this thesis is to stress the importance of germinal factors, in particular those which, at least in theory, might lead to disturbances in the ripening process of the human egg. We were put on this track by some data concerning the circumstances under which one of our patients presumably had been conceived.

Obstetrics and gynaecology are seeing growing numbers of legal disagreements with high levels of damages. Often the insurer, or the patient, reaches an out-of-court settlement with the doctor. This book, which is unique in the field, contains a large number of case examples from forensic obstetrics, special considerations in evaluation, the level of damages and the judgements reached. The case examples, which are both authentic and memorable, are helpful in drawing up and judging statements of expert opinion on obstetrical cases.

Together with Willibald Pschyrembel I tried to present and summarize the new subject of perinatal medicine in a concise overview, using simple words. Coupling the didactic skill of the older author with the enthusiasm of the younger author, texts were written that were scrutinized word for word, rejected and accepted. For me, looking back several decades, I would say that my training and formation as an author were more important than the publishing and sales of the book. Prof. Dr. med. Joachim W. Dudenhausen"

This book focuses on conveying autoimmune disease expertise to gynecologists and other clinicians, allowing them to approach the treatment of each disease in a pragmatic manner. Each chapter reviews the current literature on treatments for autoimmune diseases, especially under special circumstances like pregnancy; rating disease severity; and providing practical guidelines based on the current state of knowledge. How autoimmune diseases affect fertility, and how to best prepare patients with these diseases for pregnancy, is also addressed. Unfortunately the current literature does not provide effective guidelines. This book addresses that shortcoming, and will help clinicians to implement appropriate treatments, while also outlining possible alternatives in order to provide effective treatment for women living with autoimmune diseases. It also explores important issues concerning autoimmune diseases in women such as: lupus nephritis, vasculitis, Sjogren's syndrome, anti phospholipid syndrome and systemic sclerosis, and their potential effects on unborn children. Given its scope, the book offers a valuable reference guide for Practicing Clinicians, Rheumatologists and Gynecologists, among others.

The Operation Primer provides excellent photographic step-by-step guidance to the surgical procedure. It has been produced to describe the operation in the simplest manner possible without over-simplifying. At the core of the Operation Primer is the section on Nodal Points, where the key surgical steps are described in detail. This surgical guide book provides essential reference material for surgeons wishing to update their knowledge in this specific area.

The Operation Primer Laparoscopic Hysterectomy is specially intended for those gynecologists who wish to familiarize themselves with minimally invasive hysterectomy techniques. This Operation Primer is an excellent teaching tool, accurately describing a standardized technique not only for novices but also for experienced laparoscopic surgeons. It provides a detailed overview of presurgical considerations and preparation, key surgical steps and highlights possible pitfalls of laparoscopic hysterectomy.

This Operation Primer on total laparoscopic hysterectomy (TLH) and laparoscopic supracervical hysterectomy (LASH or LSH) follows the step-by-step concept and provides a detailed manual for gynecologists who want to apply laparoscopic techniques for hysterectomy.

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CONGENITAL AND PERINATAL INFECTIONS provides a concise and clinically-oriented primer on the congenital and perinatal infections likely to present in clinical practice. Written with the busy clinician in mind, it combines easy accessibility with state-of-the-art information on the epidemiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prevention of congenital and perinatal infections. Eschewing the notion that congenital and perinatal infections only encompass agents from the TORCH group of pathogens, this volume offers comprehensive information on the spectrum of viral, bacterial, and parasitic infections that can manifest in mother or child. Combined with its brevity and emphasis on clinical management, CONGENITAL AND PERINATAL INFECTIONS is a definitive new guide to understanding this challenging group of infections.

Although there are far more opportunities for LGBTQ people to become parents than there were before the 1990s, attention to the reproductive challenges LGBTQ families face has not kept pace. Reproductive Losses considers LGBTQ people's experiences with miscarriage, stillbirth, failed adoptions, infertility, and sterility. Drawing on Craven's training as a feminist anthropologist and her experiences as a queer parent who has experienced loss, Reproductive Losses includes detailed stories drawn from over fifty interviews with LGBTQ people (including those who carried pregnancies, non-gestational and adoptive parents, and families from a broad range of racial/ethnic, socio-economic, and religious backgrounds) to consider how they experience loss, grief, and mourning. The book includes productive suggestions and personal narratives of resiliency, commemorative strategies, and communal support, while also acknowledging the adversity many LGBTQ people face as they attempt to form families and the heteronormativity of support resources for those who have experienced reproductive loss. This is essential reading for scholars and professionals interested in LGBTQ health and family, and for individuals in LGBTQ communities who have experienced loss and those who support them. See additional material on the companion website: www.lgbtqreproductiveloss.org/

Epidural Anaesthesia: Images, Problems and Solutions brings together the most comprehensive collection of post-block epidurograms in the world into a single volume. With accompanying X-rays and contrast injection images, it clearly explains why an epidural block has failed and provides practical advice on how to avoid complications in the future. Key featuers: Contains over 180 clearly labelled X-rays and contrast injection images to help you learn using these examples. Uses X-rays and contrast injection images rather than more complext imaging technologies, to allow quick assessment of blocks in the most basic radiology department. Written by a world-renowned expert, providing consistency of style and approach throughout. Companion website contains downloadable images as well as moving X-rays of contrast injection, 3D reconstructions and explanatory cartoons. This unique book for specialist and trainee anaesthetists demonstrates, with simple X-rays and contrast injection, why epidurals are occasionally imperfect. Epidural Anaesthesia: Images, Problems and Solutions will enable you to refine your technique and avoid adverse outcomes in practice.