This book constitutes the refereed proceedings of the 13th International Workshop on Breast Imaging, IWDM 2016, held in Malmoe, Sweden, in June 2016. The 35 revised full papers and 50 revised poster papers presented together with 6 invited talks were carefully reviewed and selected from 89 submissions. The papers are organized in topical sections on screening; CAD; mammography, tomosynthesis, and breast CT; novel technology; density assessment and tissue analysis; dose and classification; image processing, CAD, breast density, and new technology; contrast-enhanced imaging; phase contrast breast imaging; simulations and virtual clinical trials.

This unique textbook is designed to provide a summary of state of the art developments in both male and female fertility and its association with cancer for both new and experienced practitioners. Clear, concise and readable, the text allows the reader to obtain rapid answers to this challenging medical issue. Special emphasis is placed on diagnostic and treatment algorithms. Topics covered include demographics of cancer in the reproductive age male, fertility conditions which predispose to cancer development, the role of assisted reproduction for fertility management, as well as fertility preservation strategies for the male and female cancer patients. Cancer and Fertility will be of great value to general urologists, uro-oncologists, gynecologists, medical oncologists, obstetricians, primary care providers, allied health providers.

Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women's health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists.

This book presents the latest evidence-based guidelines for perinatal management and is designed to help obstetricians and neonatologists minimize complications and offer patients the best possible care. Since 1960, there has been a significant increase in basic and clinical investigations on normal and pathological pregnancy in the developed world. This has provided insights into the physiopathology of pregnant women, fetuses and newborns and led to the development of new technologies, bringing about a new medical subspecialty: perinatal medicine. The book is divided into eight main sections: The first examines basic periconceptional care and discusses the ethical aspects of perinatology. The next section focuses on prenatal considerations, such as the nutritional aspects of gestation and puerperium, physical exercise during pregnancy, routine laboratory tests, prenatal care of multiple gestations and the role of the neonatologist in prenatal care. The third and fourth sections then explore fetal evaluation, and clinical intercurrences in pregnancy, respectively. The next section addresses pregnancy complications: prevention, diagnosis and management. The sixth section covers the basic aspects of congenital infections and the seventh examines labor and delivery aspects. Lastly, the final section includes chapters on neonatal assistance. Written by leading experts in obstetrics, neonatology, and perinatology, this thoroughly updated, comprehensive resource reflects the latest information in all areas, including genetics and imaging.

Providing a comprehensive review of the interactions between exercise and human reproduction, this unique text focuses on both the positive and negative consequences of sport and physical activity on male and female fertility and infertility and the biological mechanisms and processes behind them. Beginning with a review of the structure and function of the male and female reproductive systems as well as fertilization and gestation, the discussion then turns to the physiology and endocrinology of sport and exercise, which is further elaborated in subsequent chapters on the impact of physical activity, hormonal changes, pathologies, and consequences of drug use for active men and women. Additional chapters address related topics, such as the impact of sport on young athletes and developing reproductive potential, physical activity and pregnancy, the use of oral contraceptives in athletes, oxidative stress, and the impact of nutritional deficiencies on athletes' fertility, with a final chapter providing recommendations and therapeutic guidelines for exercise-related reproductive disorders. Covering everything from the fundamental principles of sports physiology and human reproductive potential to the interaction between physical exercise and the endocrinology of the reproductive system, Exercise and Human Reproduction is an authoritative resource for helping clinicians understand how the reproductive system adapts to activity and exercise and offers strategies to avoid potential harm to human reproduction.

Legal Concepts and Best Practices in Obstetrics provides valuable information on the medical legal aspects of obstetrics, offering an important learning opportunity for obstetricians and trainees, as well as midwives, nurses, attorneys, and hospital administrators. Written by Dr. Steven Warsof, a seasoned maternal-fetal medicine specialist with extensive experience in the legal aspects of obstetrics, this unique resource not only familiarizes readers with today's medical legal process, but also presents case studies on common medical legal issues with commentary on how outcomes might have been improved. Provides a comprehensive summary of each case along with the clinical outcome, perspectives of the plaintiff and defendant, outcome of the case (when known), best practices for prevention (with a focus on preventable vs. non-preventable risk), standard points of care, and key takeaway points. Offers best practices for prevention and highlights key learning points for minimizing preventable risk. Includes chapters by notable maternal-fetal medicine specialists and attorneys with expertise in this complex area. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This fully revised and updated second edition of Sexual Health and Genital Medicine in Clinical Practice covers the range of conditions seen in genitourinary medicine, sexual health and sexually transmitted infection clinics, making it a useful and practical guide to all health practitioners in this area. This book is aimed at medical practitioners who require a quick reference guide to help with diagnosis and management of genital problems. In addition, it provides essential guidance on what to do next when faced with a patient presenting with a genital complaint, whether the patient can be successfully treated with a drug regimen or needs to be referred up to the Sexual Health and Genital Medicine specialist. Sexual Health and Genital Medicine in Clinical Practice will be of particular interest to residents on their rotations through this field of medicine, doctors in training, specialist nurses, and primary care practitioners.

Over the past 10 years, studies have shown that the rates of fertility vary in different ethnic groups. Ethnic differences also play a significant role in the outcome of assisted reproductive technology (ART) cycles. In the United States, minority groups--African Americans, Hispanics (mainly Mexicans and Central Americans), East Asians (Chinese, Japanese, Koreans, Philippinos) and South Asians (Indians, Pakistanis, and Bengalis)--have significantly lower chances of live births compared to Caucasian women. Birth outcome data collected by the Society for Assisted Reproductive Technology shows a worsening trend in conception rates between the years 1999-2000 and 2004-2006, raising more concern that the disparity in fertility rates between minority groups and white women is widening over time. This comprehensive book serves to answer the questions that arise when managing infertility in a multi-ethnic population. An expert assembly of key leaders in the field of reproductive medicine imparts insight and clinical experience in order to identify and analyze the possible causes of racial disparities in fertility outcome. Some of the reviewed causes include higher Body Mass Index (BMI), tubal diseases, metabolic syndrome, and fibroids in African Americans; tubal disease and higher early pregnancy loss in Hispanics; higher incidence of diminished ovarian reserve and lower BMI in East Asians; and higher incidence of polycystic ovarian disease (PCOS) in South Asians. The book also provides a review of data on access to care and ART services in developing countries. A thoughtful combination of evidence-based medicine and advanced treatment options, this book is sure to distinguish itself as the definitive reference on ethnic differences in assisted reproduction.

The causative organisms of Urinary Tract Infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treatment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Urinary Tract Infections addresses key questions facing physicians about this condition. This book is written primarily for general physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also find the book useful as a quick reference guide.

Now in its fourth volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques and evolving controversies in reproductive medicine. An impressive panel of contributors presents cutting-edge information in a clear and well-balanced manner. Volume 4 discusses hot topics in contemporary reproductive medicine, including stem cell technologies for male infertility, the current state of ovarian tissue cryopreservation and time-lapse video microscopy of embryos. The expanded section on controversies allows for point/counterpoint discussion between experts with differing opinions on topics like eSET and the use and role of dietary supplements in IVF cycles. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all clinicians and researchers working to help couples resolve their infertility.

This book outlines the current understanding of how obesity affects female reproductive function across the lifespan. Topics include physiology of the menstrual cycle and early pregnancy, best practices in the delivery of contraceptive and prenatal care and healthcare policy that weighs the evidence in appropriate balance with principles that respect women's rights. Special attention is devoted to the idea that obesity's adverse effects are likely trans-generational; that is, children born to obese mothers are at increased risk for obesity, diabetes and cardiovascular disease later in life. Patients and their physicians need to be aware of the additional risks obesity confers in pregnancy and outline a plan of care that includes counseling preconceptionally, antepartum, intrapartum and postpartum in order to decrease morbidity. Obesity and Fertility provides advice for reproductive medicine physicians and gynecologists to help guide obese patients toward improved reproductive health and outcomes.

This book on post-injury multiple organ failure (MOF) offers a comprehensive overview and clinically focused practical guide to treating the condition. MOF is arguably the most difficult complication to manage in polytrauma patients and is responsible for the majority of trauma deaths among patients who survived the first 24 hours after injury. Beyond mortality, it has a major impact on healthcare resource utilization and a persistent negative effect on patients' long-term reported outcomes. This book is edited by surgeons who are passionate about the topic, and about optimizing the outcomes for polytrauma patients. Grasping the fascinating pathophysiology of MOF is essential for providing patients with quality early care. Each chapter highlights key learning objectives, historical perspectives, diagnostic and therapeutic pearls, and includes a must-know summary, additional reading suggestions and future research directions. Flowcharts, decision-making guides, summary tables, graphics and clinical photographs help to maximize the learning experience and to ensure readers retain what they've learned. The book fills a unique niche area for many specialties dedicated to critical care of polytrauma patients and to their management before and beyond intensive care.

This book provides a comprehensive overview on issues surrounding fertility in patients who have been diagnosed with breast cancer or belong to a high-risk population. The impact of breast cancer treatment on fertility is clearly explained and all the available options for fertility preservation are discussed, including the use of assisted reproduction technologies. Guidance is offered on family planning and on management options when breast cancer arises during pregnancy and when pregnancy occurs after breast cancer. Answers are provided to a wide range of key questions, including: What is the impact of pregnancy after breast cancer on prognosis? What advice should be given on the timing of pregnancy in relation to chemotherapy and endocrine treatment? What is the effect of reducing the duration of endocrine treatment to allow an earlier attempt at pregnancy? Is breast feeding possible? Medical treatments of breast cancer have a huge impact on fertility. While many procedures can be applied to preserve fertility, all must be put into action within the very short time available before starting treatment. Any delay in referral of a woman wishing to preserve her fertility to an ART center with experience in oncologic patients may preclude the possibility of a future pregnancy. In addition, an increasing number of high-risk patients are asking questions about their reproductive life, from choice of contraception to the risks of assisted reproduction techniques. Physicians will find this book an invaluable aid in providing flawless counseling to their patients and ensuring that they receive optimal management.

This full-colour, richly-illustrated book is an excellent source of rapidly retrievable information on aspects of relevance in daily clinical practice in the outpatient breast clinic. Expert guidance is provided on a full range of topics, including pitfalls of clinical examination, imaging and related tissue diagnosis, approaches to management decision-making in different disorders, the role of surgery and adjuvant therapy, follow-up and rehabilitation. In outpatient breast clinics, effective communication with patients must be established in order to address symptoms that in most cases are not serious but can be very worrying and sometimes lead to misdiagnosis and also to litigation. Outpatient consultations also offer an opportunity to encourage a healthy lifestyle and to provide information on matters such as risk assessment, screening and the most reliable websites. A well-functioning outpatient clinic is essential to a breast unit's overall proficiency. Readers will find this book an invaluable aid to good practice. The authors place particular emphasis on quality indicators and key priorities for implementation of the main guidelines, at the same time specifying the level of evidence for them and degree of recommendation. Practical measures for achieving the best results are highlighted, and helpful advice is provided on optimizing patient communication and reducing the psychological burden.

This book fills the gap in understanding of pathology of the female genital tract that is often understated during training. Normal histology and pathology of abnormal conditions are covered for the lower and upper genital tract, in a concise manner with over 200 color illustrations. Topics include this covers inflammatory diseases, iatrogenic conditions, changes associated with menopause, and benign and malignant neoplasms. This text also address adjunctive testing such as molecular diagnostics and immunohistochemistry staining. The text is concise and practical with a liberal use of bullet points, and it includes clinicopathologic correlations. Breakout tables in each chapter cover information the clinician should provide the pathologist to get the most useful report, as well as pathology issues and challenges that may result in a report less specific than the clinician is expecting. Written by board certified experts, this book is the ultimate resource for gynecological pathologists, obstetrics, OB/GYN physicians, and gynecology practitioners.

Comprised exclusively of clinical cases covering ectopic pregnancy, this concise, practical casebook will provide clinicians in reproductive medicine and obstetrics/gynecology with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different management strategies - from treatment with methotrexate to surgical interventions - as well as types of ectopic pregnancy, such as ovarian, interstitial, heterotopic and abdominal forms, among others. Pragmatic and reader-friendly, Ectopic Pregnancy: A Clinical Casebook will be an excellent resource for reproductive medicine specialists, obstetricians and gynecologists, and family and emergency medicine physicians alike.

It is challenging enough to be able to make a diagnosis in mammography, but the newer standards of care demand more than just providing a diagnosis. This book is an excellent resource to improve the understanding of breast diseases, recognize and manage problems encountered in breast imaging and clinical management of the breast diseases. With forty four chapters, this volume is divided into six sections on screening of breast cancer, imaging modalities, benign breast disorders, interventional procedures, pathological considerations and breast cancer. Breast Diseases: Imaging and Clinical Management is a crisp volume on clinical and multimodality breast imaging with emphasis on interventional procedures, pathology and the entire spectrum of breast cancers.

In the last decades, major advances have been made in assisted reproductive technologies (ART) and the public demand for these procedures has increased globally. All ART clinics, from those just starting out to the well established, must employ the latest equipment and implement the best practices, while ensuring that their resources are effectively engaged to optimize patient outcomes. This is a tenet of the fiduciary role of physicians and it is increasingly recognized as a quantifiable goal regulated by formal certifications and accreditations. Quality management protocols such as those proposed by the International Organization for Standardization (ISO) are being rapidly adopted as standards of measure. Quality Management in ART Clinics: A Practical Guide provides easily adoptable ways to implement and improve formalized quality management systems. Essential to any clinic to achieve best practices and maintenance of formal regulatory certifications, this book brings together the know-how of experienced opinion leaders operating in key areas worldwide. The book offers an overview of primary regulations in the ART field, with attention to quality management demands, and links specific requirements to practical steps for implementation. Filled with process and procedure examples, flow diagrams and administrative form templates, this book is the first of its kind, gathering the necessary elements for optimizing practice, management, and quality assurance.

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

Based on the experience of two Italian referral centers, the book depicts the characteristic findings obtained when using MR imaging to study the male and female pelvis including the obstetric applications. Each chapter provides a comprehensive account of the use of the imaging technique of examination, including the most recent advances in MR imaging, the anatomy and MR possibilities in the identification, characterization and staging of the different pelvic diseases highlighting its diagnostic possibilities. The advances in fetal MRI, representing the cutting edge of pelvic MR imaging, will also be depicted. The text is complemented by numerous illustrations, as well as clinical cases that make this a very practice-oriented work, presenting the role of diagnostic imaging in every-day clinical activity. The volume will prove an invaluable guide for both residents and professionals with core interest in gynecology, obstetrics and urology.

A collection of cutting-edge laboratory techniques for the study of trophoblast and placental biology. The techniques presented range from experimental animal models, to animal and human placental organ and cell culture systems, to morphological, biochemical, and molecular strategies for assessing trophoblast/placental growth, differentiation and function. Volume 1 provides readily reproducible protocols for studying embryo-uterine implantation, trophoblast cell development, and the organization and molecular characterization of the placenta. Highlights include strategies for the isolation and culture of trophoblast cells from primates, ruminants, and rodents, and precise guidance to the molecular and cellular analysis of the placental phenotype. A companion second volume concentrates on methods for investigating placental function.