Seasonal patterns have been found in a remarkable range of health conditions, including birth defects, respiratory infections and cardiovascular disease. Accurately estimating the size and timing of seasonal peaks in disease incidence is an aid to understanding the causes and possibly to developing interventions. With global warming increasing the intensity of seasonal weather patterns around the world, a review of the methods for estimating seasonal effects on health is timely.

This is the first book on statistical methods for seasonal data written for a health audience. It describes methods for a range of outcomes (including continuous, count and binomial data) and demonstrates appropriate techniques for summarising and modelling these data. It has a practical focus and uses interesting examples to motivate and illustrate the methods. The statistical procedures and example data sets are available in an R package called season .

In September 2005, Yerevan (Armenia) hosted an International Conference dedicated to the 70th anniversary of the publication of the so called "green paper," published by N.W. Timofeeff-Ressovsky, K. Zimmer and M. Delbruck in 1935, entitled "On the origin of gene mutations and gene structure." The importance of this paper for genetics and radiobiology was enormous a" not only for radiobiology, but for genetics in general. The "target" of the radiation action was indeed the "gene," that for the first time found a clear, operational definition. The organisers of this Conference proposed to convene scientists from all over the world to discuss the impact of radiation risk estimates in normal and emergency situations. This was the starting point of the NATO Advanced Research Workshop, whose proceedings are published in this book. The parallel development of the Conference and the Workshop resulted in a true synergism, both events taking advantage from the mixed environment of molecular biologists, geneticists, radiobiologists, radioecologists, biophysicists, etc. gathered in Yerevan. We were delighted to include a few excellent papers dealing directly with Timofeeff-Ressovskya (TM)s life and the "green pamphlet." The life and scientific achievements of Timofeeff-Ressovsky are often not well known in western countries, hence we deemed it advisable to include those papers in this book.

Anja Schmidt's thesis is a unique and comprehensive evaluation of the impacts of tropospheric volcanic aerosol on the atmosphere, climate, air quality and human health. Using a state-of-the-art global microphysics model, the thesis describes and quantifies the impact of volcanic sulphur emissions on global aerosol, clouds and the radiative forcing of climate. The advanced model enables the first ever estimate of the impact of the emissions on aerosol microphysical properties such as particle number concentrations and sizes, and therefore a considerably improved ability to quantify the climate and air quality effects.
There are several important discoveries in this thesis. Firstly, it is shown that continuously degassing volcanoes exert a major effect on global clouds and climate. Secondly, the impact of the 1783 Laki eruption in Iceland is re-examined to show that this long-lasting flood lava eruption would have had major effects on clouds and climate. Thirdly, by combining her research on volcanism, atmospheric science and epidemiology, she shows that a present-day Laki-like eruption would seriously affect European air quality and cause over 100000 premature deaths in the first year.

Homeostasis. The health of an organism is influenced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It willbe answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer.
Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation.
Metastasis. Animal tumor models serve to understand the spread of the primary tumor cells to distant locations of the organism. Different types of tumors and metastases will be reviewed. "

The book reviews and reports the recent progress and knowledge on the specific impact of current and projected urban overheating as well as of the urban mitigation technologies on mortality and morbidity and urban vulnerability. It presents recent data and developments on the topic reported by some of the more distinguished researchers in this area. In parallel, it discusses new findings related to the characteristics and the magnitude of urban overheating and reports and analyzes the recent knowledge on the synergies between urban heat island and heatwaves. This book helps to advance our understanding on the interaction between Urban Heat Island (UHI) and overheating as well as their impact on energy demand and public health globally. Exploring the interaction between UHI and energy consumption requires the understanding on the dynamics of UHI intensity and air pollution index in different land use and how such interactions may vary in different cities in the world. Moreover, this book focuses on different cities in Australia, Austria, Belgium, Brazil, Canada, Cyprus, Greece, Hong Kong, India, Asia, Spain, UK, and USA.

This book pursues a multidisciplinary approach in order to evaluate the socio-ecological dimensions of infectious diseases in Southeast Asia. It includes 18 chapters written by respected researchers in the fields of history, sociology, ecology, epidemiology, veterinary sciences, medicine and the environmental sciences on six major topics: (1) Infectious diseases and societies, (2) Health, infectious diseases and socio-ecosystems; (3) Global changes, land use changes and vector-borne diseases; (4) Monitoring and data acquisition; (5) Managing health risks; and (6) Developing strategies. The book offers a valuable guide for students and researchers in the fields of development and environmental studies, animal and human health (veterinarians, physicians), ecology and conservation biology, especially those with a focus on Southeast Asia.

The destruction of the ozone layer, together with global warming, is one of the hot environmental topics of today. This book examines the effect of human activities on atmospheric ozone, namely the increase of tropospheric ozone and the general diminution of stratospheric ozone and the production of the Antarctic ozone hole. Also discussed is the role of remote sensing techniques in the understanding of the effects of human activities on atmospheric ozone as well as in the development of social and political awareness of the damage to the ozone layer by man-made chemicals, principally CFCs. This led to the formulation and ratification in 1989 of the Montreal Protocol on controlling/banning the manufacture and use of chemicals that damage the ozone layer. Since then, remote sensing has played a key role in monitoring atmospheric ozone concentration and determining the success of the Montreal Protocol in protecting the ozone layer from further damage. In this book, the renowned authors discuss the sophisticated instruments that have been launched into space to study not only ozone but also other trace gases in the atmosphere, some of which play a key role in the generation and destruction of ozone in the atmosphere. Professors Cracknell and Varotsos also examine the satellite-flown instruments which are involved in monitoring the absorption of solar ultraviolet light in the atmosphere in relation both to the generation and destruction of ozone and consequently to human health. This scholarly book, written by the foremost experts in the field, looks at remote sensing and its employment in the various aspects of ozone science. It is widely acknowledged that global warming, due to anthropogenic greenhouse gases emissions, represents a threat to the sustainability of human life on Earth. However, many other threats are potentially just as serious, including atmospheric pollution, ozone depletion, water pollution, the degradation of agricultural land, deforestation, the depletion of the world's mineral resources and population growth.

Complex chemical mixtures impact our health every day. In the United States, and also in Central and Eastern Europe, there are a number of locations where complex chemical mixtures have been released to environmental media. Although exposure to mixtures is common, minimal information exists to quantify these exposures, or to determine their impact on human or ecological receptors. These proceedings present some of the most current research conducted to quantify complex mixtures in the environment and investigate their potential impact on human health. Many of the manuscripts reported in these proceedings represent the most up-to-date measurements of population exposures in Central and Eastern Europe. These studies are of value to health and environmental professionals around the world as they develop strategies for assessing exposures, remediating contaminated environments, and improving public health.

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker H2AX: from bench science to clinical trials What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children's exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

In recent decades radiobiologists' efforts have been directed at identifying the mechanisms of radiation effects; the general mechanisms have since been studied extensively. This book describes and analyzes radiation-induced adaptation as processes produced in cells, tissues, and populations. This viewpoint helps to understand the nature and factors of induced processes, to determine the characteristics of observed radiation effects and their limitations. The investigations presented here were founded on proper lab experiments, ecological studies of plant population growth near an operating nuclear power plant and a thorough epidemiological examination of human populations living in territories polluted fifty years ago, as well as on relevant published data. This research demonstrates the radiation-induced adaptation processes that continue even when the radiation itself is no longer at a critical background level. The investigations utilized the method of statistical modeling on the basis of distributions on the number of abnormalities. This method allows us to investigate the processes induced by low-dose factors when accompanied by Darwinian selection in different systems; the distribution parameters can then be used to study the characteristics of adaptation processes and system resistance. The consequences of background-level radiation continue to provoke debate, and the mathematical bases of the adaptation model are shown, while due consideration is paid to the components of adaptation: instability, selection, and proliferation. The book will be especially useful to specialists in radiation pollution, ecology, epidemiology, and radiology for studies of radiation-induced processes; the method presented here can also be adapted to investigate low-dose effects in other fields. In addition, the book presents a number of reviews in the fields of radiation biology, including pioneering investigations in Russia which were previously unavailable to Western scientists.

This volume provides an overview of the occurrence and fate of emerging contaminants, discusses advanced chemical analysis methods, toxicological and ecotoxicological effects as well as human exposure. One focus is on pharmaceuticals, in particular antibiotics, and the problems associated with their increased use in hospitals. Other covered emerging contaminants occurring e.g. in food, water, air or soil include brominated flame retardants, polar pesticides, phthalates, phosphate esters, perfluorinated compounds, personal care products, musk fragrances, disinfection byproducts, illicit drugs, and nanomaterials. The chapters written by experts are a valuable source of information for a broad audience, such as analytical chemists, environmental chemists and engineers, toxicologists, ecotoxicologists and epidemiologists working already in this field as well as newcomers.

This book offers a meaningful and practicable guide to better management of arsenic problems in the groundwater of the Gangetic Plain. It gathers contributions from distinguished researchers who have been actively working in the area for over a decade. The arsenic contamination of groundwater is a growing concern in the central Gangetic Plain, where the local population's main sources of fresh water are surface water, groundwater and rain water; of these sources, only the last two generally meet the most important criteria for drinking water in their natural state. Natural geological changes are presumed to be the primary reason for arsenic contamination in this region. Further, most of the people living in this area have developed the habit of drinking water (groundwater) from the arsenic-contaminated tubewells in many parts of the region. As a result, many are suffering from arsenicosis and many more are at risk. Since the cause of arsenic contamination in groundwater still remains unclear, this book seeks to address the arsenic issue in this region by pursuing a holistic and systematic scientific approach. Accordingly, it delineates various sources, processes, hypotheses and remedial approaches that are needed to manage the arsenic contamination in the Central Gangetic Plain.

This book offers a selection of the best articles presented at the CUPUM (Computers in Urban Planning and Urban Management) Conference, held in the second week of July 2017 at the University of South Australia in Adelaide. It provides a state-of-the-art overview of the availability and application of planning support systems (PSS) in the context of smart cities, big data, and urban futures. Rapid advances in computing, information, communication and web-based technologies are reaching into all facets of urban life, creating new and exciting urban futures. With the universal adoption of networked computing technologies, data generation is now so massive and all pervasive in society that it offers unprecedented technological solutions for planning and managing urban futures. These technologies are essential to effective urban planning and urban management in an increasingly challenging world, with socially disruptive changes, more complex and sophisticated urban lives and the need for resilience to deal with the possibility of adverse future environmental events and climate change. The book discusses examples of these technologies which encompass, inter alia: 'smart urban futures', where cities with myriad sensors are networked with communication technologies that enable the city planners to monitor well-being and be responsive to citizens' needs to allow dynamic management in real-time; PSS that encompass new hardware, develop new indicators, applications and innovative ways of facilitating public and community involvement in the management and planning of urban areas; and urban modelling that draws on theory and the richness of data from the growing range of urban sensing and communication technologies to build a better understanding of urban dynamics, trends and 'what-if' scenario investigations, and to provide better tools for planning and policymaking.

Adds three new chapters (constructed wetlands, stream sediments, and rice production systems) and is updated throughout Examines the adaptation of wetland plants to varying anaerobic soil conditions Provides the basic concepts involved in biogeochemical cycling of nutrients and contaminants in wetlands as related to environmental significance and ecological functions Examines the role of microbial processes in sulfate reduction, denitrification, and methane production Provides case studies for key biogeochemical processes governing wetland function in freshwater wetlands

Microbial or biological degradation has long been the subject of active concern, and the rapid expansion and growing sophistication of various industries in the last century has significantly increased the volume and complexity of toxic residues of wastes. These can be remediated by plants and microbes, either natural origin or adapted for a specific purpose, in a process known as bioremediation. The interest in microbial biodegradation of pollutants has intensified in recent years in an attempt to find sustainable ways to clean contaminated environments. These bioremediation and biotransformation methods take advantage of the tremendous microbial catabolic diversity to degrade, transform or accumulate a variety of compounds, such as hydrocarbons, polychlorinated biphenyls, polaromatic hydrocarbons pharmaceutical substances, radionuclides and metals. Unlike conventional methods, bioremediation does not physically disturb the site. This book describes the basic principles of biodegradation and shows how these principles are related to bioremediation. Authored by leading, international environmental microbiologists, it discusses topics such as aerobic biodegradation, microbial degradation of pollutants, and microbial community dynamics. It provides valuable insights into how biodegration processes work and can be utilised for pollution abatement, and as such appeals to researchers and postgraduate students as well as experts in the field of bioremediation.

A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system.

Three main themes are discussed:

• Nanoparticle sources and production
• Nanoparticle inhalation and deposition
• Toxicological and medical consequences of nanoparticles

Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.

Reports on waste valorization in the winemaking industry and converting the waste into more useful products including oils, antioxidants and other valuable materials. Explores research which contributes to environmental sustainability and circular economy in the winemaking industry. Describes other ways to reduce the ecological footprint of the wine industry such as using less fertilizer, more benign pesticides and reduction of water footprint. Proposes options for a potential wine waste biorefining. Reviews alternative uses of agro-industrial wine wastes as sources of additives for the food, cosmetic and pharmaceutical industries.

This publication characterizes the environmental burden of disease in the United Arab Emirates (UAE), measured by the excess number of deaths and illnesses in the population due to exposure to environmental hazards. The robust methods used in this risk analysis can be applied to any country or region. This publication documents the systematic, multi-step process used to identify environmental priorities and the detailed methods used to quantify the disease burden attributable to each risk. Based on the results of the burden of disease assessment, the publication summarizes the subsequent steps that are recommended to further reduce the burden of disease resulting from various environmental risk factors.

Authors and Contributors
This book represents the synthesis of research carried out by a large, interdisciplinary team from several institutions and multiple nations between June 2008 and June 2011.The lead authors are responsible for weaving together the pieces prepared by the team.Nonetheless, this book would not have been possible without major contributions from each team member.The list below shows contributors to each chapter.Following this list are biographies of all of the authors and contributors.

Lead Authors

Jacqueline MacDonald Gibson, Frederic J. P. Launay, Jens T. W. Thomsen, Angela Brammer, Christopher Davidson

Additional Contributors (by Chapter)

Chapter 2: Prioritizing Environmental Risks to Health
Henry H. Willis, Aimee Curtright, Gary Cecchine, Zeinab S. Farah, Sandra A. Geschwind, Jianhui Hu, Ying Li, Melinda Moore, Sarah Olmstead, Hanine Salem, Regina A. Shih, J. Jason West

Chapter 3: Assessing the Environmental Burden of Disease: Method Overview
TiinaFolley, Elizabeth S. Harder, MejsHasan

Chapter 4: Burden of Disease from Outdoor Air Pollution
Ying Li, GavinoPuggioni, PrahladJat, MejsHasan, Marc Serre, Kenneth G. Sexton, J. Jason West, SaravananArunachalam, Uma Shankar, William Vizuete, Mohammed ZuberFarooqui

Chapter 5: Burden of Disease from Indoor Air Pollution
Chris B. Trent

""

Chapter 6: Burden of Disease from Occupational Exposures
TiinaFolley, LeenaA. Nylander-French

Chapter 7: Burden of Disease from Climate Change
Richard N. L. Andrews, Leslie Chinery, Elizabeth S. Harder, J. Jason West

Chapter 8: Burden of Disease from Drinking Water Contamination
Gregory W. Characklis, Joseph N. LoBuglio

Chapter 9: Burden of Disease from Coastal Water Pollution
Gregory W. Characklis, Leigh-Anne H. Krometis, Joseph N. LoBuglio
Chapter 10: Burden of Disease from Soil and Groundwater Contamination
Chidsanuphong Chart-asa, Stephanie Soucheray-Grell

Chapter 11: Burden of Disease from Produce and Seafood Contamination
Leigh-Anne H. Krometis, Leslie Chinery"

Environmental sustainability issues in a fragile, semi-arid region and its coastal area, which experience climate changes from extreme drought conditions to the effects of hurricanes over a period of weeks to years, provide specific challenges for the ecosystems and the populations existing within the region. The research presented focuses on the problems and some solutions specific to the South Texas-Mexico border region, on both sides of the Rio Grande, focusing on water and air pollution. "

This book examines ways in which families' physical environments have implications for their relationships and the health and well-being of their members. Attention is given to three aspects of the physical environment-disasters, climate change, and the built environment-and the challenges these may create for families. Chapters describe particular considerations within each of these three physical environment challenges, the ways they affect families, and factors that protect families, promote their resilience and enable them to flourish. Finally, the volume offers recommendations for the role of government programs and policies to support families to overcome and/or adapt to environmental challenges as well as highlights the efficacy of evidence-based interventions aimed at promoting family resilience.Featured areas of coverage include: Extreme natural events and families' postdisaster recovery. Family adaptations to climate change. The built environment and children's health and well-being. Community-driven approaches to address environmental inequities. The urban environment of family caregiving. Environmental Impacts on Families is a must-have resource for researchers, professors, and graduate students as well as clinicians, therapists, policymakers, and other related professionals in developmental psychology, family studies, environmental health and policy, social work, public health, educational policy and politics, economics, migration studies, and all interrelated disciplines.

This book examines the policy and politics of two health risks, which have recently become prominent social issues in many countries. One is the issue of asbestos as an environmental risk to humans, and another is that of bovine spongiform encephalitis (BSE), or mad cow disease as an animal disease, and of its variant Creutzfeldt-Jakob disease (CJD) as a human food risk. Employing a set of analytical frameworks in political science, each case study explores how the issues emerged, agendas got set, alternatives were chosen, and policies were implemented. Through the analysis, it is examined how safety and public reassurance were pursued in the countries studied (Japan, the UK, France the USA, and Korea). Exploration of the successes and failures in their efforts discloses the key elements to successful health risk management.

Antimicrobial resistance is recognised among the world’s most challenging problems. Despite its global spread, Africa, specifically sub-Saharan Africa, is the most affected by this malaise. Poor living conditions and inadequate access to sanitation and potable water supplies are among contributing factors that have influenced a high disease burden on the continent, requiring extensive antimicrobials. Weak health systems and the absence of firm policies further aggravate the problem, as the use of antimicrobials is mostly unregulated. The increasing demand for animal protein to meet the starving populations’ demands has also influenced the use of these antimicrobials, including those banned on other continents, for food animal production. The ripple effect of indiscriminate use in humans and animals is the massive discharge of antimicrobials, their residues, antimicrobial-resistant microorganisms and their associated genes into the environment.  This 14-chapter unique masterpiece presents the AMR problem in African, addressing the various compartments of the One Health – humans, animals, and the environment, to illustrate the need for concerted efforts in the fight against AMR, especially in Africa. Authors from the four cardinal points present diverse aspects of AMR in Africa, starting with behavioural and social drivers of AMR in Africa. Antimicrobial stewardship in an African context is also discussed. AMR in humans is presented through studies on antibiotic-resistant neonates and nontyphoidal Salmonella infections and the clinical relevance of the genetics of viral resistance. Topics on AMR in mastitis, biosecurity in animal farming and the linkage between disinfectants and AMR are discussed. The environmental dimension of AMR is discussed, notably in the aquatic environment, and its implication for aquaculture and irrigation and using nanomaterials to treat polluted waters from such environments are highlighted. Finally, Africa’s rich floral diversity is portrayed as an eco-friendly and cost-effective approach to combat AMR. Hopefully, the work presented will spur greater collaboration between scientists, environmental, animal and human health practitioners, the general population, and policymakers to assimilate and implement the One Health approach to combating AMR, rather than working in silos on their various sectors

This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

From a new perspective, namely focusing on the interaction of selenium and mercury, this thesis provides new insights into traditional research on biogeochemical cycles of mercury in soil-plant interaction and associated human exposure and risks. The subject of this thesis is both valuable and timely, providing essential information not only on selenium-mercury interaction in the soil-plant system but also on how to assess the combined benefits and risk of co-exposure to mercury and selenium. This work also sheds light on future aspects regarding prevention, remediation and risk management for environmental mercury contamination. Presenting high-quality papers published in leading international SCI journals such as Environmental Health Perspectives and Environmental Science & Technology and having been recognized with the Special Award of Presidential Scholarship Award and Excellent Doctoral Dissertations Prize of the Chinese Academy of Sciences (CAS), this thesis offers a valuable resource for scientific communities, policy-makers and non-experts who are interested in this field.

Dr. Hua Zhang works at the Norwegian Institute for Water Research (NIVA), Oslo, Norway.