Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Stem Cell Therapy: Practical Considerations addresses the biological properties of stem cells, mechanisms of action; as well as actual therapeutic decisions such as cell type, source, dose, manipulation, and route of injection. After discussing all this data, the book will illustrate how to travel through the idea from abstract question to laboratory experiment, animal experiment and then on to design a clinical trial throughout all its phases. Written for scientists and postgraduate students in the field of stem cell research and therapy. The authors will cover practical therapeutic issues they have long experienced in the field.

Play is not only a kind of activity, but also a set of attitudes. We may join a card game in a casino without assuming a play attitude; conversely we may transform a seemingly tedious action, such as a walk to the store, into a pleasant experience of spontaneous movements by adopting an attitude of play. Attitudes of Play is a comprehensive study of the persistent human tendency to bring a cheerful and good-humoured outlook to any kind of situation, including the serious and the mundane. Gabor Csepregi offers a phenomenological description of forms of playfulness, showing how, time and again, our attitudes of play redefine and shape diverse activities and experiences - from teaching, healing, or worshipping to political conflict or walking down the street. With play attitudes, we exercise our freedom to colour these scenes or give them an altogether new form, evoking in us more refined sentiments and more acute perceptions. This book seeks to distinguish play activities from attitudes of play, showing that the latter hold value not merely for their educational or other instrumental benefits but also, and perhaps most importantly, for the overall fulfillment and well-being they offer in all stages of human existence.

Childhood obesity has reached epidemic proportions in the United States and continues to increase in prevalence in almost all countries in which it has been studied, including developed and developing countries around the globe. The causes of obesity are complex and multi-factorial. Childhood obesity becomes a life-long problem in most cases and is associated with long term chronic disease risk for a variety of diseases including type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, as well as psychosocial as issues and obesity seems to affect almost every organ system in the body. In recent years there has been tremendous progress in the understanding of this problem and in strategies for prevention and treatment in the pediatric years. Childhood Obesity: Causes, Consequences, and Intervention Approaches presents current reviews on the complex problem of obesity from the multi-level causes throughout early life before adulthood and the implications for this for long-term disease risk. It reviews numerous types of strategies that have been used to address this issue from conventional clinical management to global policy strategies attempting to modify the global landscape of food, nutrition, and physical activity. Each chapter is written by a global authority in his or her respective field with a focus on reviewing the current status and recent developments. The book features information on contributing factors to obesity, including developmental origins, social/family, birth cohort studies, influence of ethnicity, and global perspectives. It takes a life-course approach to the subject matter and includes exhaustive treatment of contributing factors to childhood obesity, such as assessment, environmental factors, nutrition and dietary factors, host factors, interventions and treatment, consequences, and further action for future prevention. This broad range of topics relevant to the rapidly changing field of childhood obesity is suitable for students, health care professionals, physicians, and researchers.